갈근에서 분리한 화합물의 α-glucosidase와 α-amylase 활성 저해 효과
α-Glucosidase and α-Amylase Inhibitory Activity of Compounds from Roots Extract of Pueraria thunbergiana
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Abstract
Compounds of isolated from roots extract of Pueraria thunbergiana were tested their inhibitory effects on α- glucosidase and α-amylase. Inhibitory activity of methylene chloride (MC) fraction and ethyl acetate (EA) fraction against α-glucosidase showed more than 60% at a concentration of 500㎍/㎖. Among the nine compounds tested on α-glucosidase, biochanin A, (−)-tuberosin and calycosin from MC fraction and daidzein from EA fraction were stronger inhibitors than acarbose (IC50 = 530㎍/㎖), and their IC50 were 9, 144, 328 and 20㎍/㎖, respectively. Biochanin A and (−)-tuberosin also inhibited α-amylase activity as like as acarbose IC50 = 20.5 ㎍/㎖), and their IC50 were 22 and 348 ㎍/㎖, respectively. Although daidzein was already known α-glucosidase inhibitory effects, it was newly evaluated that biochanin A and (−)- tuberosin inhibited α-glucosidase as well as α-amylase, and that calycosin did α-glucosidase.
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