고려인삼의 식품 안전성에 관한 임상 연구
Clinical Study on Food Safety evaluation of Panax ginseng
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
In this study, the clinical safety and toxicology of oral ingestion of supplement capsules containing ginseng radix was investigated in healthy young volunteers. This study was a pilot randomized, double blinded, placebo controlled trial. The healthy volunteers were divided into 6 groups of 20 each (10 males and 10 females). They took the ginseng powder for 35 days (3g/day) for safety evaluation. There were measured general healthy levels such as hematological, biochemical and electrocardiographic parameters. After the first week, besides Korean white ginseng the other treatments led to an significant increase of white blood cells. Korean red ginseng increased UREA (blood urea nitrogen) in healthy volunteers, but it didn’t exceed the range of normal values, and in the subsequent process of treatment there is no effect of elevating UREA. After the three weeks, Korean white ginseng showed relatively low the content of blood glucose and low-density lipoprotein cholesterol. After the five weeks, compared with the other treatments, Korean red ginseng increased white blood cells, platelet distribution width and average volume of platelet. Korean white ginseng decreased low-density lipoprotein cholesterol. American ginseng decreased blood creatinine in healthy volunteers. In conclusion, through test the blood routine, urine routine, liver function, renal function, blood glucose, blood lipid and electrocardiogram, the healthy volunteers continuous taking ginseng for 35 days (3 g/day) is safe and reliable, and have no obvious adverse reactions and side effects.
Abstract
In this study, the clinical safety and toxicology of oral ingestion of supplement capsules containing ginseng radix was investigated in healthy young volunteers. This study was a pilot randomized, double blinded, placebo controlled trial. The healthy volunteers were divided into 6 groups of 20 each (10 males and 10 females). They took the ginseng powder for 35 days (3g/day) for safety evaluation. There were measured general healthy levels such as hematological, biochemical and electrocardiographic parameters. After the first week, besides Korean white ginseng the other treatments led to an significant increase of white blood cells. Korean red ginseng increased UREA (blood urea nitrogen) in healthy volunteers, but it didn’t exceed the range of normal values, and in the subsequent process of treatment there is no effect of elevating UREA. After the three weeks, Korean white ginseng showed relatively low the content of blood glucose and low-density lipoprotein cholesterol. After the five weeks, compared with the other treatments, Korean red ginseng increased white blood cells, platelet distribution width and average volume of platelet. Korean white ginseng decreased low-density lipoprotein cholesterol. American ginseng decreased blood creatinine in healthy volunteers. In conclusion, through test the blood routine, urine routine, liver function, renal function, blood glucose, blood lipid and electrocardiogram, the healthy volunteers continuous taking ginseng for 35 days (3 g/day) is safe and reliable, and have no obvious adverse reactions and side effects.
참고문헌 (12)
- Al-Gwaiz LA, "The diagnostic value of absolute neutrophil count, band count and morphologic changes of neutrophils in predicting bacterial infections", Medical Principles and Practice, 16, pp.344~347 (2007)
- Fauci AS., "Harrison’s principles of internal medicine", pp.611~ (2011)
- 한진수, "인삼의 연근과 직경에 따른 뿌리 조직의 비율 및 Ginsenoside 함량 변화", 한국약용작물학회지, 21(5), pp.342~347 (2013), 한국약용작물학회
- Ji HJ, "The Korean herbal pharmacopoeia of the Korean pharmacopoeia", pp.636~ (1987), Korean Medical Index
- 김영창, "인삼 종자의 개갑률 향상을 위한 적정 수확시기 및 GA3 처리 효과", 한국약용작물학회지, 22(6), pp.423~428 (2014), 한국약용작물학회[DOI]
- Laki K., "Our ancient heritage in blood clotting and some of its consequences", Annals of the New York Academy of Sciences, 202, pp.297~307 (1972)
- 이종원, "건강기능식품의 시장현황 및 인삼시장의 전망", Journal of Ginseng Research, 29(4), pp.206~214 (2005), 고려인삼학회
- Daly ME, "Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high starch diet", American Journal of Clinical Nutrition, 67, pp.1186~1196 (1998)
- Mitchell LJ, "Evaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule : A randomized control trial", Regulatory Toxicology and Pharmacology, 63, pp.313~320 (2012)
- Murakawa M, "Acquired von Willebrand’s disease in association with essential thrombocythemia : Regression following treatment", Acta Haematologica, 87, pp.83~87 (1992)
- Nam KY, "Usage and dosage of ginseng radix based upon traditional and recent scientific clinical applications", Journal of Ginseng Research, 24, pp.99~105 (2000)
- Park CK, "Current status of ginseng products in market of health functional food", The Korean Ginseng Research and Industry, 1, pp.9~16 (2007)