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Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study

이혜리|김홍배|정동혁|심재용|나하영|이용제|박병진
대한가정의학회 (The Korean Academy Of Family Medicine)|2012.07|Korean Journal of Family Medicine|제33권 제4호|pp. 190-196|DOI http://dx.doi.org/

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참고문헌

키워드

Randomized Controlled TrialMetabolic SyndromePanax ginseng
주제분류가정의학

초록

Background: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters,inflammatory markers, and arterial stiffness in subjects with metabolic syndrome. Methods: We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d)group or a placebo group for a 12-week study. We collected anthropometric measurements, blood for laboratory testing,and brachial-ankle pulse wave velocity (baPWV) at the initial (week 0) and final (week 12) visits. Results: A total of 48 subjects successfully completed the study protocol. Oral administration of KRG did not significantly affect blood pressure, oxidative or inflammatory markers, or baPWV. Conclusion: We found no evidence that KRG had an effect on blood pressure, lipid profile, oxidized low density lipoprotein,fasting blood glucose, or arterial stiffness in subjects with metabolic syndrome. These findings warrant subsequent longer-term prospective clinical investigations with a larger population. Trial Registration: ClinicalTrials.gov Identifier: NCT00976274

Abstract

Background: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters,inflammatory markers, and arterial stiffness in subjects with metabolic syndrome. Methods: We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d)group or a placebo group for a 12-week study. We collected anthropometric measurements, blood for laboratory testing,and brachial-ankle pulse wave velocity (baPWV) at the initial (week 0) and final (week 12) visits. Results: A total of 48 subjects successfully completed the study protocol. Oral administration of KRG did not significantly affect blood pressure, oxidative or inflammatory markers, or baPWV. Conclusion: We found no evidence that KRG had an effect on blood pressure, lipid profile, oxidized low density lipoprotein,fasting blood glucose, or arterial stiffness in subjects with metabolic syndrome. These findings warrant subsequent longer-term prospective clinical investigations with a larger population. Trial Registration: ClinicalTrials.gov Identifier: NCT00976274

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