인삼이 혈압에 미치는 영향: 체계적 문헌고찰 및 메타분석
Effect of Ginseng on Blood Pressure: A Systematic Review and Meta-Analysis
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Objective: A meta-analysis was performed to determine effect of ginseng on blood pressure. Methods: The databases of PubMed, Embase, Cochrane Library, RISS, DBpia, KISS, and Koreamed were searched for all published studies from inception to January 2016. The following terms were used: “ginseng”, “hypertension”, and “blood pressure”. Using the Review Manager 5, mean differences (MDs) were pooled to measure the effect of ginseng on blood pressure compared to that of placebo. Results: Eleven randomized controlled trials were included. In this meta-analysis, ginseng treatment significantly lowered systolic blood pressure (SBP) in a dose-independent way (MD: −1.99, p = 0.04). In subgroup analysis, 8-12 week consumption of ginseng achieved significantly greater reduction in SBP (MD: −3.14, p = 0.03), while single administration of ginseng failed to show BP-lowering effect. When ingested over 8-12 weeks, ginseng significantly lowered diastolic blood pressure (DBP) (MD: −1.96, p = 0.03). No significant association was found between ginseng dose and the magnitude of BP-lowering effect. However, a significant positive relationship was observed between baseline SBP level and the magnitude of SBP reduction (r = 0.848, p = 0.033). Such a relationship was not seen in DBP. Conclusion: Consumption of ginseng for 8-12 weeks achieved significant reductions in SBP and DBP in a dose-independent way. There was a significant positive relationship between baseline SBP level and the magnitude of SBP reduction.
Abstract
Objective: A meta-analysis was performed to determine effect of ginseng on blood pressure. Methods: The databases of PubMed, Embase, Cochrane Library, RISS, DBpia, KISS, and Koreamed were searched for all published studies from inception to January 2016. The following terms were used: “ginseng”, “hypertension”, and “blood pressure”. Using the Review Manager 5, mean differences (MDs) were pooled to measure the effect of ginseng on blood pressure compared to that of placebo. Results: Eleven randomized controlled trials were included. In this meta-analysis, ginseng treatment significantly lowered systolic blood pressure (SBP) in a dose-independent way (MD: −1.99, p = 0.04). In subgroup analysis, 8-12 week consumption of ginseng achieved significantly greater reduction in SBP (MD: −3.14, p = 0.03), while single administration of ginseng failed to show BP-lowering effect. When ingested over 8-12 weeks, ginseng significantly lowered diastolic blood pressure (DBP) (MD: −1.96, p = 0.03). No significant association was found between ginseng dose and the magnitude of BP-lowering effect. However, a significant positive relationship was observed between baseline SBP level and the magnitude of SBP reduction (r = 0.848, p = 0.033). Such a relationship was not seen in DBP. Conclusion: Consumption of ginseng for 8-12 weeks achieved significant reductions in SBP and DBP in a dose-independent way. There was a significant positive relationship between baseline SBP level and the magnitude of SBP reduction.
참고문헌 (27)
- 백인호, "The world ginseng market and the ginseng (Korea)", Journal of Ginseng Research, 37(1), pp.1~7 (2013), 고려인삼학회
- Choi KT, "Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer", Acta Pharmacol Sin, 29, pp.1109~1118 (2008)
- Chun-Su Yuan, "Chemical and Pharmacological Studies of Saponins with a Focus on American Ginseng", Journal of Ginseng Research, 34(3), pp.160~167 (2010), 고려인삼학회
- de Andrade E, "Study of the efficacy of Korean red ginseng in the treatment of erectile dysfunction", Asian J Androl, 9, pp.241~244 (2007)
- Kim HG, "Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial", PLoS One, 8, pp.e61271~ (2013)
- 방향주, "Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus", Journal of Medicinal Food, 17(1), pp.128~134 (2014), 한국식품영양과학회[DOI]
- Lee ST, "Panax ginseng enhances cognitive performance in Alzheimer disease", Alzheimer Dis Assoc Disord, 22, pp.222~226 (2008)
- Ossoukhova A, "Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults", Hum Psychopharmacol, 30, pp.108~122 (2015)
- Yu J, "Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells:a possible involvement of androgen receptor", Biochem Biophys Res Commun, 353, pp.764~769 (2007)
- Hien TT, "Ginsenoside Rg3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: essential roles of estrogen receptordependent PI3-kinase and AMP-activated protein kinase", Toxicol Appl Pharmacol, 246, pp.171~183 (2010)
- Kang YJ, "Relaxation of canine corporal smooth muscle relaxation by ginsenoside saponin Rg3 is independent from eNOS activation", Life Sci, 77, pp.74~84 (2005)
- Guan YY, "Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+channels in vascular smooth muscle cells", Eur J Pharmacol, 548, pp.129~136 (2006)
- Cai BX, "Ginsenoside-Rd, a new voltage-independent Ca2+ entry blocker, reverses basilar hypertrophic remodeling in stroke-prone renovascular hypertensive rats", Eur J Pharmacol, 606, pp.142~149 (2009)
- 정익모, "Korean Red Ginseng Improves Vascular Stiffness in Patients with Coronary Artery Disease", Journal of Ginseng Research, 34(3), pp.212~218 (2010), 고려인삼학회
- Stavro PM, "Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function", Hypertension, 47(4), pp.791~796 (2006)
- Stavro PM, "North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension", Hypertension, 46, pp.406~411 (2005)
- Jovanovski E, "Modulation of endothelial function by Korean red ginseng (Panax ginseng C.A. Meyer) and its components in healthy individuals: a randomized controlled trial", Cardiovasc Ther, 32, pp.163~169 (2014)
- Higgins J, "Cochrane handbook for systematic reviews of interventions. Version 5.1.0. Chapter 8: Assessing risk of bias in included studies", The Cochrane Collaboration, ~ (2011)
- 권동현, "비만 여성에서 유전자 다형성 및 한방 변증 유형에 따른 홍삼의 비만 개선 효과 : 무작위 배정, 이중 맹검, 위약 대조 임상시험", 석사, 한의학, pp.2011
- Rhee MY, "Effect of Korean red ginseng on arterial stiffness in subjects with hypertension", J Altern Complement Med, 17, pp.45~49 (2011)
- Eunjung Lim, "Effects of Korean red ginseng supplementation on blood pressure, nitric oxide concentration and renin-angiotensin-aldosterone system in subject with prehypertension and stage 1 hypertension", 석사, Dept. of Food and Nutrition, pp.2012
- 박병진, "Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study", Korean Journal of Family Medicine, 33(4), pp.190~196 (2012), 대한가정의학회[DOI]
- Cha TW, "Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA(2) activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects", pp.2015
- Mucalo I, "Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2diabetes and concomitant hypertension", Journal of Ethnopharmacology, 150, pp.148~153 (2013)
- Shishtar E, "Effects of Korean white ginseng (Panax Ginseng C.A. Meyer) on vascular and glycemic health in type 2 diabetes: results of a randomized, double blind, placebo-controlled, multiple-crossover, acute dose escalation trial", Clin Nutr Res, 3, pp.89~97 (2014)
- 허명행, "Ginseng for Reducing the Blood Pressure in Patients with Hypertension: A Systematic Review and Meta-Analysis", Journal of Ginseng Research, 34(4), pp.342~347 (2010), 고려인삼학회
- Sung J, "Effects of red ginseng upon vascular endothelial function in patients with essential hypertension", Am J Chin Med, 28, pp.205~216 (2000)