본문 바로가기
KERD
논문

산겨릅나무 줄기추출물의 생리활성 및 유효성분 분리

Biological Activities and Bioactive Compounds in the Extract of Acer tegmentosum Maxim. Stem

이지원|권용수|정종현|김재광|유창연|조동하|김명조|이찬옥|엄석현|홍보경
한국약용작물학회|2007.08|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제15권 제4호|pp. 296-303

2

조회

0

다운로드

25

인용

0

참고문헌

초록

Abstract

Acer tegmentosum (Acereaceae) has been used a source of traditional medicines for the treatment of hepatic disorders in Korea. This research was conducted to determine biofunctional activities of A. tegmentosum stem extract and to identify its bioactive components. Methanolic extract from A. tegmentosum stem was partitioned by using organic solvents, including n-hexane, ethyl acetate, n-butanol, and water. Two compounds were isolated by using an ODS column chromatography from ethyl acetate soluble fraction shown to the strongest antioxidant activity (RC50 = 3.15㎍/㎖) among the fractions. The isolated compounds were analyzed by 1H and 13C NMR, IR, UV/VIS, MS spectrum data and identified as catechin, ρ-Hydroxyphenethyl alcohol 1-O-ß-D-(6"-O-galloyl)-glucopyranoside. The compounds have shown strong antioxidant activity, with similar activity to BHA (RC50 = 2㎍/㎖). Especially, ρ-Hydroxyphenethyl alcohol 1-O-ß-D-(6"-O-galloyl)- glucopyranoside was shown strong anti-lipid peroxidative activity. However, the compounds were not shown antimicrobial activities. In antimicrobial activity assays, ethyl acetate soluble fraction was effective to bacterial inhibition, such as Escherichia coli and Klebsiella pneumonia, with minimum inhibitory concentrations in 125㎍/㎖. Otherwise, antifungal activity against Candida albicans was shown in n-hexane soluble fraction exhibiting 63㎍/㎖ of minimum inhibitory concentration. In anticomplementary activity assays, water soluble fraction was the most effective exhibiting 24% inhibitory activity.

참고문헌 (24)

  1. "Inhibitory action of silymarin of lipid peroxidation formation in rat liver mitochondria and microsomes", 26, pp.2405~2409 (1997)
  2. "Screening for antioxidant activitiy of plants and marine algaeand its active principles from Prunus daviana. Korean Journalof Pharmacology 24", pp.299~303 (1993)
  3. "Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical", 21, pp.895~902 (1996)
  4. "Antioxidative compounds in extracts of Acer ginnala Max", 7, pp.51~57 (1999)
  5. "Isolation of phenolic glucosides from the stems of Acer tegmentosum Max", 49, pp.149~152 (2006)
  6. "Antioxidative effect ofthe constituents of rosemary", pp.521~528 (1983)
  7. "Anti- and pro-oxidant activity of rutin and quercetin derivatives", 55, pp.131~142 (2003)
  8. "Characterization and action mode of anticomplementary substance prepared from Lactobacillus plantarum", 34, pp.290~295 (2002)
  9. "Phenolic compounds from the node of lotus rhizome (Nelumbo nucifra Gaertn)", 45, pp.599~603 (2001)
  10. "Genetic variation in urushiol components of Rhus verniciflua Stokes", 29, pp.115~123 (1997)
  11. "Identification of three competitive inhibitors for membrane associated, Mg2+- dependent and neutral 60kDa sphingomyelinase activity", 28, pp.923~929 (2005)
  12. "Anticomplementary activity and immune-stimulating effect of the extracts from barley (Hordeum vulgare)", 13, pp.661~668 (1997)
  13. "Microassay for colorimetric estimation of complement activityin guinea pig", pp.215~220 (1983)
  14. "Uptake and exudation of phenolic compounds by wheat and antimicrobial components of the root exudate", 51, pp.527~533 (1996)
  15. "Tannins and relatedcompounds seven new phenol glucoside gallates from Quercusstenophylla Makino. Chemical and Pharmaceutical Bulletin30", pp.2061~2067 (1982)
  16. "Antimicrobial constituents from the stem bark of Feronia limonia", 59, pp.73~77 (2002)
  17. "Antibacterial substances in Japanese green tea extract againstStreptococcus mutans", pp.2307~2311 (1989)
  18. "Phenolic antioxidants.Critical Reviews in Food Science and Nutrition 32", pp.67~103 (1992)
  19. "The influenceable of plant extracts of inside Gangwon-do on AGS cell and Hep3B cell growth control", 16, pp.39~45 (2005)
  20. "Antioxidative effects of phenylethanoids from Cistanche deserticola", 19, pp.1580~1585 (1996)
  21. "Water-soluble glucans from the seed of Coixlaorymajobi var. Ma-Yuen. Phytochemistry 25", pp.129~ (1989)
  22. "Antimicrobial effect of tea extracts from gren tea, oolong tea and black tea", 24, pp.293~298 (1995)
  23. "산겨릅나무 (Acer tegmentosum Maxim.)의 페놀성성분연구" (2006)
  24. "한국본초도감", pp.523~ (1998), 교학사

관련 논문AI추천

고로쇠와 우산고로쇠 저온고압 수용성 추출물의 유용생리활성 비교강하영, 김승섭, 오성호, 이학주, 이현용, 정명훈, 하지혜한국약용작물학회 · 한국약용작물학회지2009 · 제17권 제6호복분자 열매 추출물의 유용 생리활성 탐색김종대, 오덕환, 유창연, 이미경, 이현수, 이현용, 최근표한국약용작물학회 · 한국약용작물학회지2003 · 제11권 제1호Antioxidant and Anticancer Activities of Leaves Extracts from Acer tegmentosum강연경, 김다솜, 박광훈, 박영기, 어현지한국자원식물학회 · 한국자원식물학회지2020 · 제33권 제6호한국산 자생 수목 유래 수피추출물의 종양괴사인자 억제효과조재열한국약용작물학회 · 한국약용작물학회지2007 · 제15권 제4호느릅나무와 시무나무의 항산화 활성이승은한국약용작물학회 · 한국약용작물학회지2004 · 제12권 제4호고로쇠와 우산고로쇠 나무의 부위별 항암 및 면역조절능 비교Syed Abdul Qadir한국약용작물학회 · 한국약용작물학회지2007 · 제15권 제6호

이 간행물의 다른 논문 (12건)

강화 사자발쑥의 항암활성 증진을 위한 추출조건의 최적화유상권, 권민철, 박욱연, 최근표, 이현용, 김철희, 김효정, 이상희pp. 233-240쥐오줌풀 부정근으로부터 valepotriates와 valerenic acid 생산에 미치는 elicitor의 효과박형재, 김홍실, 이미양, 황성진, 남승현, 황백, 김미란pp. 241-245쥐오줌풀 부정근으로부터 valepotriates와 valerenic acid생산에 미치는 elicitor의 효과김홍실pp. 241-245참돌꽃의 캘러스로부터 salidroside 생산에 미치는 배지성분의 영향박형재, 최혜진, 황성진, 황백, 이재승, 안준철pp. 246-250화서제거 시기가 바위솔의 생장과 개화에 미치는 영향전승호, 이창우, 강진호, 신성철, 김홍영pp. 251-255
원문 보기