본문 바로가기
KERD
논문

Determination of Luteolin in the Different Parts of Lithospermum erythrorhizon by HPLC

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

초록

The content of luteolin in the different parts of Lithospermum erythrorhizon was determined by high performance liquid chromatography (HPLC). Luteolin was quantified by a reverse-phase column with gradient solvent program (water : ACN = 90 : 10 to 77 : 23 for 60 min). UV detection was conducted at 330㎚. The content of luteolin was measured in the seeds (0.28 ㎎/g), stems (0.30 ㎎/g), and roots (0.16 ㎎/g) of L. erythrorhizon. The presence of luteolin in Lithospermum species is important in agricultural crop production for increasing the amounts of clinically available medicine and health supplements.

Abstract

The content of luteolin in the different parts of Lithospermum erythrorhizon was determined by high performance liquid chromatography (HPLC). Luteolin was quantified by a reverse-phase column with gradient solvent program (water : ACN = 90 : 10 to 77 : 23 for 60 min). UV detection was conducted at 330㎚. The content of luteolin was measured in the seeds (0.28 ㎎/g), stems (0.30 ㎎/g), and roots (0.16 ㎎/g) of L. erythrorhizon. The presence of luteolin in Lithospermum species is important in agricultural crop production for increasing the amounts of clinically available medicine and health supplements.

참고문헌 (25)

  1. Chen Z, "Shikonin,a component of Chinese herbal medicine,inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1", Antimicrobial Agents and Chemotherapy, 47, pp.2810~2816 (2003)
  2. Chung JG, "Inhibitory actions of luteolin on the growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from ulcer patients", Toxicology in Vitro, 15, pp.191~198 (2001)
  3. Cho MH, "Propionylshikonin from the roots of Lithospermum erythrorhizon", Archives of Pharmacal Research, 22, pp.414~416 (1999)
  4. Elisa T, "Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review", Food Chemistry, 104, pp.466~479 (2007)
  5. Han J, "Antioxidants from a Chinese medicinal herb:Lithospermum erythrorhizon", Food Chemistry, 106, pp.2~10 (2008)
  6. Hu C, "Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW 264.7 cell", Molecular and Cellular Biochemistry, 265, pp.107~113 (2004)
  7. OkJinHwang, "Optimization of major culture elements on growth and Shikonin production in the Lithospermum erythrohizon Hairy Root Culture", 한국약용작물학회지, 10(4), pp.2~248 (2002), 한국약용작물학회
  8. Ishida T, "Protection of human keratinocyes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon", Biological & Pharmaceutical Bulletin, 30, pp.928~934 (2007)
  9. 정미정, "민들레와 두종의 엉겅퀴의 Rat lens aldose reductase 억제활성", Journal of Applied Biological Chemistry, 51(6), pp.302~306 (2008), 한국응용생명화학회
  10. Kang JS, "Enantiomeric ratio of shikonin derivatives as a possible key for the determination of the origin of Lithospermi Radix", Archives of Pharmacal Research, 21, pp.565~569 (1998)
  11. Kim GS, "Inhibitory effect of acetylshikonin from Lithospermum erythrorhizon on LDL oxidation and FPTase activity", Korean Journal of Medicinal Crop Science, 14, pp.522~523 (2006)
  12. Kuroda M, "Novel cholestane glycosides from the bulbs of Ornithogalum saundersiae and their cytostatic activity on leukemia HL-60 and MOLT-4 cell", Tetrahedron, 53, pp.1549~1562 (1997)
  13. Lee JH, "Isolation and identification of red color pigments from the Korean Lithospermum erythrorhizon", Journal of Food Science and Nutrition, 13, pp.379~382 (2000)
  14. Sun-Hee Lee, "Luteolin Inhibits Extracellular Signal-Regulated Kinase Pathway ThroughProtease-Activated Receptors (-2 and -4) and Their Agonist Activity", Natural Product Sciences, 13(2), pp.169~173 (2007), 한국생약학회
  15. Morimoto I, "Naphtohquinone derivatives from Lithospermum erythrorhizon Siebold.et Zuccarini", Tetrahedron Letters, 52, pp.4737~4739 (1965)
  16. Jun Yeon Park, "A Paraben Derivative from the Seeds of Lithospermum erythrorhizon", Journal of the Korean Society for Applied Biological Chemistry, 52(6), pp.643~645 (2009), 한국응용생명화학회
  17. Jun Yeon Park, "Phytochemical Constituents from the Seeds of Lithospermum erythrorhizon", Natural Product Sciences, 15(4), pp.181~184 (2009), 한국생약학회
  18. Shen CC, "Antimicrobial activities of naphthazarins from Arnebia euchroma", Journal of Natural Products, 65, pp.1857~1862 (2002)
  19. Tabata M, "Pigment formation in callus cultures of Lithospermum erythrorhizon", Phytochemistry, 13, pp.927~932 (1974)
  20. Ternai B, "Carbon-13 NMR studies of flavonoids-1:Flavones and flavonols", Tetrahedron, 32, pp.565~569 (1976)
  21. Touno K, "Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythrorhizon", Plant Physiology and Biochemistry, 43, pp.101~105 (2005)
  22. Yamasaki K, "Screening test of crude drug extract on anti-HIV activity", Yakugaku Zasshi, 113, pp.818~824 (1993)
  23. Yingming P, "Antioxidant activities of several Chinese medicine herbs", Food Chemistry, 88, pp.347~350 (2004)
  24. You YJ, "(E)-6-(1-Alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-nepthoquinones:synthesis,cytotoxic activity and antitumor activity", Bioorganic & Medicinal Chemistry Letters, 10, pp.2301~2303 (2000)
  25. Zhang HZ, "Chemical and pharmacological research progress of Chinese drug ‘Zicao’", Natural Product Research and Development, 14, pp.74~78 (2002)

관련 논문AI추천

An HPLC-UV-based quantitative analytical method for Chrysanthemum morifolium: development, validation, and applicationDasom Jung, Heesoo Lee, Jeong Ho Geum, Jeongmi Lee, Jin Hak Kim, Ke Li, Keunbae Park, Seulgi Kang한국분석과학회 · 분석과학2019 · 제32권 제4호지치의 생육시기 및 재배지역별 시코닌계 색소 함량 및 항산화 활성김금숙, 김승유, 노형준, 박춘근, 이경희, 이승은, 이정훈, 최재훈한국약용작물학회 · 한국약용작물학회지2011 · 제19권 제6호배암차즈기 추출물의 기능성원료 표준화를 위한 지표성분으로서 Hispidulin의 분석법 평가곽호영, 이제혁, 전윤정, 최수임, 최종길한국약용작물학회 · 한국약용작물학회지2016 · 제24권 제4호Variation of Caffeic acid, Rosmarinic acid, Luteolin and Apigenin Contents in Perilla Germplasm김현경, 박금룡, 박순기, 박창환, 배석복, 심강보, 이명희, 정찬식, 하태정, 황정동한국육종학회 · 한국육종학회지2009 · 제41권 제4호Optimization of an extraction method for the simultaneous quantification of six active compounds in the aril part of Orostachys japonicus using HPLC–UV김형민, Chong Woon Cho, Dan Gao, Jin Hyeok Kim, Jong-Seong Kang, Seo Young Yang, Young Ho Kim한국분석과학회 · 분석과학2021 · 제34권 제4호건조 방법에 따른 환삼덩굴 추출물 중 Luteolin 유도체의 함량 변화이경인, 최철희, 표병식한국약용작물학회 · 한국약용작물학회지2023 · 제31권 제6호

이 간행물의 다른 논문 (8건)