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구아바 잎 열수추출물의 당류분해효소 저해 효과 및 OGTT에 미치는 효과

Effect of Aqueous Extract of Guava (Psidium guajava L.) Leaves on the Oral Glucose Tolerance Test and Inhibition of Glycoside Hydrolase

김화영|홍성길|황성주|정지상|최수민|김중학|장혜은
한국약용작물학회|2012.04|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제20권 제2호|pp. 94-100|DOI http://dx.doi.org/

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참고문헌

키워드

DiabetesPolyphenolGuavaPsidium guajavaGlycoside Hydrolase

초록

Guava (Psidium guajava) contain a great deal of polyphenol compound and work on the treatment of Diabetes mellitus effectively. In this study, the bioactivities of aqueous extract (GLEx) of guava leaf were investigated. Total phenolic contents of GLEx was 266.9 ㎎ tan/g. The effects of GLEx on digestive enzymes, α-amylase, maltase and sucrase were investigated. IC50 values of GLEx against α-amylase, maltase and sucrase were 0.65 ㎎/㎖, 2.0 ㎎/㎖ and 3.5 ㎎/㎖ respectively. The effect of GLEx on oral glucose tolerance test (OGTT) was performed in normal ICR mouse, control (dstilled water) and GLEx (aqueous extract of Guava leaf) were co-administered orally with glucose, showed reducing effect on the blood glucose level. The guava is likely to useful for prevention or improvement of hyperglycemia by lowering the blood glucose level and inhibiting glycoside hydrolase activity.

Abstract

Guava (Psidium guajava) contain a great deal of polyphenol compound and work on the treatment of Diabetes mellitus effectively. In this study, the bioactivities of aqueous extract (GLEx) of guava leaf were investigated. Total phenolic contents of GLEx was 266.9 ㎎ tan/g. The effects of GLEx on digestive enzymes, α-amylase, maltase and sucrase were investigated. IC50 values of GLEx against α-amylase, maltase and sucrase were 0.65 ㎎/㎖, 2.0 ㎎/㎖ and 3.5 ㎎/㎖ respectively. The effect of GLEx on oral glucose tolerance test (OGTT) was performed in normal ICR mouse, control (dstilled water) and GLEx (aqueous extract of Guava leaf) were co-administered orally with glucose, showed reducing effect on the blood glucose level. The guava is likely to useful for prevention or improvement of hyperglycemia by lowering the blood glucose level and inhibiting glycoside hydrolase activity.

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관련 논문AI추천

구아바(Psidium guajava L.) 잎의 항산화 활성 및 tyrosinase 저해효과박병재, Michio Onjo한국자원식물학회 · 한국자원식물학회지2008 · 제21권 제5호구아바 열매와 잎 열수 추출물의 신경세포 보호효과곽지현, 김대옥, 김지혜, 박수정, 심기환, 정창호, 정희록, 최귀남, 최성길, 허호진한국식품저장유통학회 · Food Science and Preservation2011 · 제18권 제1호Inhibitory Effects of Artemisia capillaris Thumb.on α-Glucosidase and α-Amylase김창현, Sung-Jin Lee한국약용작물학회 · 한국약용작물학회지2007 · 제15권 제2호구아바 잎의 가공방법에 따른 품질특성권중호, 김미옥, 김현구, 윤성란, 이기동, 홍춘숙한국식품저장유통학회 · Food Science and Preservation2007 · 제14권 제6호Inhibitory activity of Euonymus alatus against alpha-glucosidase in vitro and in vivo김명진, 김미은, 김정인, 송지현, 이수경, 조자임, 황지연한국영양학회 · Nutrition Research and Practice2007 · 제1권 제3호Psidium guajava L. leaf extract inhibits adipocyte differentiation and improves insulin sensitivity in 3T3-L1 cellsBaek Seoyoung, Esther Choi, Kim Hye-Kyeong, Kuanglim Baek한국영양학회 · Nutrition Research and Practice2021 · 제15권 제5호

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