기능성분 고함유 단삼 품종 ‘홍단’의 재배 특성 및 성분 함량
Cultivation and Quality Characterization of New Variety Salvia miltiorrhiza “Hongdan” with High Active Ingredients
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초록
Background: Salvia miltiorrhiza Bunge, commonly known as Danshen belongs to the Lamiaceae family and is a perennial medicinal crop with purple flowers and red roots. Originated in China, this plant is known for its medicinal properties and has recently been cultivated for medicinal purposes in Korea as well. Methods and Results: In 2007, plants were selected from seedlings grown through open pollination based on the “Dasan” variety, followed by replicated yield trials in 2016 - 2018 and local adaptability testing in 2019 - 2020. This process confirmed that “Hongdan” possesses yield potential comparable to that of “Dasan”. Salvianolic acid B and tanshinone IIA contents were analyzed using high-performance liquid chromatography, while the other components, hydrophilic phenolic acid and hydrophobic tanshinone, were also analyzed separately. “Hongdan” had higher contents of salvianolic acid B and tanshinone IIA, indicating its potential as a high-quality medicinal variety. “Hongdan” generally has a generally high content of hydrophilic phenolic acids and hydrophobic tanshinones. Conclusion: “Hongdan” demonstrated excellent yield and was found to have a higher content of active ingredients than the “Dasan”. This study highlights the potential of “Hongdan” as an excellent source of medicinal and functional food.
Abstract
Background: Salvia miltiorrhiza Bunge, commonly known as Danshen belongs to the Lamiaceae family and is a perennial medicinal crop with purple flowers and red roots. Originated in China, this plant is known for its medicinal properties and has recently been cultivated for medicinal purposes in Korea as well. Methods and Results: In 2007, plants were selected from seedlings grown through open pollination based on the “Dasan” variety, followed by replicated yield trials in 2016 - 2018 and local adaptability testing in 2019 - 2020. This process confirmed that “Hongdan” possesses yield potential comparable to that of “Dasan”. Salvianolic acid B and tanshinone IIA contents were analyzed using high-performance liquid chromatography, while the other components, hydrophilic phenolic acid and hydrophobic tanshinone, were also analyzed separately. “Hongdan” had higher contents of salvianolic acid B and tanshinone IIA, indicating its potential as a high-quality medicinal variety. “Hongdan” generally has a generally high content of hydrophilic phenolic acids and hydrophobic tanshinones. Conclusion: “Hongdan” demonstrated excellent yield and was found to have a higher content of active ingredients than the “Dasan”. This study highlights the potential of “Hongdan” as an excellent source of medicinal and functional food.
참고문헌 (41)
- Ai ZL., "Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism", World Journal of Gastroenterology, 28, pp.6131~6156 (2022)
- Ansari MA, "Prospective therapeutic potential of tanshinone IIA : An updated overview", Pharmacological Research, 164, pp.105364~ (2021)
- Bomme U, "Field cultivation of Salvia miltiorrhiza Bunge as a new medicinal plant in Germany, used for the traditional Chinese medicine", Zeitschrift für Arznei-and Gewürzpflanzen, 14, pp.25~31 (2009)
- Chang BY, "Single oral toxicity study on the standardized extract of Salvia miltiorrhiza", Korean Journal of Pharmacognosy, 39, pp.352~356 (2008)
- Chen M, ""Zhongdanyaozhi No. 1"and"Zhongdanyaozhi No. 2"are hybrid varietys of Salvia miltiorrhiza with high yield and active compounds content", Plos One, 11, pp.e0162691~ (2016)
- Chen J, "Improved stability of salvianolic acid B from radix Salviae miltiorrhizae in deep eutectic solvents", Analytical Methods, 8, pp.2502~2509 (2016)
- Chen J, "Phenotyping of Salvia miltiorrhiza roots reveals associations between root traits and bioactive components", Plant Phenomics, 5, pp.0098~ (2023)
- Chen X, "Screening of bioactive compounds in radix Salviae Miltiorrhizae with liposomes and cell membranes using HPLC", Journal of Pharmaceutical and Biomedical Analysis, 70, pp.194~201 (2012)
- Chinese Pharmacopoeia Commission(ChP), "Chinese Pharmacopoeia. Standards for component content of Salvia", pp.77~79 (2020), Chinese Pharmacopoeia Commission. Beijing Chemical Industry Press
- Choi HY, "Isolation and identification of antimicrobial compound from Dansam(Salvia miltiorrhiza Bunge)", Journal of the Korean Society of Food Science and Nutrition, 32, pp.22~28 (2003)
- Fang ZY, "Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit", Journal of Ethnopharmacology, 115, pp.217~222 (2008)
- Gao RL, "Study on establishment of near-infrared quantitative model for salvianolic acid B in naoxintong capsule based on the system modeling idea", Spectroscopy and Spectral Analysis, 40, pp.3573~3578 (2020)
- Guo R, "Pharmacological activity and mechanism of tanshinone IIA in related diseases", Drug Design, Development and Therapy, 14, pp.4735~4748 (2020)
- Jang SI, "Tanshinone IIA from Salvia miltiorrhiza inhibits expression of inducible nitric oxide synthase and production of TNF-α, IL-1β and IL-6 in activated RAW 264. 7 cells", Planta Medica, 69, pp.1057~1059 (2003)
- Jang SI, "Tanshinone IIA inhibits LPS-induced NF-κB activation in RAW 264. 7 cells : Possible involvement of the NIK-IKK, ERK1", 2, p38, and JNK pathways, 2006, pp.542, 1~7
- Jeong JT, "Cultivation and quality characterization of new variety Salvia miltiorrhiza ‘Dasan’", Korean Journal of Medicinal Crop Science, 31, pp.371~376 (2023)
- Jeong SI, "Effects of tanshinone IIA from Salvia Miltiorrhiza Bunge on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells", Korean Journal of Oriental Physiology and Pathology, 23, pp.1409~1415 (2009)
- Ji W, "Hypolipidemic activity and mechanism of purified herbal extract of Salvia miltiorrhiza in hyperlipidemic rats", Journal of Ethnopharmacology, 119, pp.291~298 (2008)
- The Korean pharmacopoeia. The second section of each item in medicine and medical supplies, "Korea Food and Drug Administration(KFDA).", Korea Food and Drug Administration, 25~26 (2012)
- Kim JC, "Correlation between growth characteristics and root yield in collected peony lines", Korean Journal of Medicinal Crop Science, 6, pp.188~192 (1998)
- Kim OH, "Anticancer activity of natural products including Salvia miltiorrhiza", Journal of Applied Pharmacology, 7, pp.29~34 (1999)
- Kim JY, "Antioxidant potential of dimethyl lithospermate isolated from Salvia miltiorrhiza(red sage)against peroxynitrite", Journal of Medicinal Food, 11, pp.21~28 (2008)
- Kuang ZA, "Salvianolic acid B exerts its anti-tumor immunity by targeting USP2 and reducing the PD-L1 level", Acta Pharmaceutica Sinica B, 58, pp.954~962 (2023)
- Lee YN., "New flora of Korea(Ⅱ)", pp.376~378 (2006), Kyohaksa corporation
- Li E, "Protective effects of Sal B on oxidative stress-induced aging by regulating the Keap1", Nrf2 signaling pathway in zebrafish, 2021, pp.26, 5239~
- Liang SM., "Improvements of emergence and tuber yield of potato in a seasonal spring arid region using plastic film mulching only on the ridge", Field Crops Research, 223, pp.57~65 (2018)
- Lu S, "Compendium of plant genomes", pp.1~15 (2019), Springer International Publishing AG
- Masarirambi MT, "Influence of plant population and seed tuber size on growth and yield components of potato(Solanum tuberosum)", International Journal of Agriculture and Biology, 14, pp.545~549 (2012)
- Final results of the 2021 census of agriculture, forestry and fisheries, "Ministry of Agriculture, Food and Rural Affairs(MAFRA).", Ministry of Agriculture, Food and Rural Affairs, 84~88 (2021)
- Pang H, "Chemical analysis of the herbal medicine Salviae miltiorrhizae Radix et Rhizoma(Danshen)", Molecules, 21, pp.51~ (2016)
- Standard method of investigation and analysis for research on the agricultural science and technology, "Rural Development Administration(RDA).", Rural Development Administration, 771~772 (2012)
- "Data by period of agricultural meteorology" (2024)[URL]
- Wan X, "Solvent extraction of tanshinone IIA from Salvia Miltiorrhiza Bunge", Korean Chemical Engineering Research, 46, pp.660~664 (2008)
- Wang MD, "Salvianolic acid B ameliorates retinal deficits in an early-stage alzheimer’s disease mouse model through downregulating BACE1 and Aβ generation", Acta Pharmacologica Sinica, 44, pp.2151~2168 (2023)
- Wen C, "New varietys of Salvia miltiorrhiza ‘Danza 1’ and ‘Danza 2’", Acta Horticulturae Sinica, 44, pp.2747~2748 (2017)
- Wu YL, "Salvia miltiorrhiza extract and individual synthesized component derivatives induce activating-transcription-factor-3-mediated antiobesity effects and attenuate obesity-induced metabolic disorder by suppressing C", EBPα in high-fat-induced obese mice, 2022, pp.11, 1022~
- Yin HQ, "Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration", Food and Chemical Toxicology, 47, pp.98~103 (2009)
- Xu L, "Stability analysis of salvianolic acid B and total phenolic acids from Salvia miltiorrhiza by HPLC and HPLC-MS", Natural Product Communications, 3, pp.671~672 (2018)
- Zhang L, "Inhibition effect and mechanism of the salvianolic acid B on the proliferation of human colon cancer HCT116 cells", Acta Pharmaceutica Sinica B, 36, pp.3268~3271 (2020)
- Zhang C, "Climatic factors control the geospatial distribution of active ingredients in Salvia miltiorrhiza Bunge in China", Scientific Reports, 9, pp.904~ (2019)
- Zhan Z, "Metabolome and transcriptome analyses reveal quality change in the orangerooted Salvia miltiorrhiza(Danshen)from cultivated field", Chinese Medicine, 14, pp.42~ (2019)
