단삼 신품종 ‘다산 ’의 재배 및 품질특성
Cultivation and Quality Characterization of New Variety Salvia miltiorrhiza ‘Dasan’
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Background: Salvia miltiorrhiza Bunge, a perennial medicinal plant belonging to the family Lamiaceae, is native to China and is cultivated in South Korea for its roots. Initially dependent on Chinese imports, recent cultivation advancements have expanded domestic production, however, developed varieties remain lacking. Methods and Results: The best lines were selected from among the offspring in 2010, replicated yield trials (RYT) were conducted in 2014, and local adaptability testing (LAT) was performed in 2015. The ‘Dasan’ line showed beneficial characteristics, including increased emergence rate and superior disease resistance against root rot compared with those of the local variety. Salvianolic acid B and tanshinone IIA were quantified as active ingredients using high performance liquid chromatography: these showed higher levels in ‘Dasan’, than in the local variety indicating its potential as a valuable medicinal variety. Simultaneously the dried root yield was 365 ㎏ per 10 a at four different regions, representing a 125% yield increase compared to that of the local variety. Conclusion: ‘Dasan’ shows promise as a variety of S. miltiorrhiza with superior growth, disease resistance, and high yield potential. This research plays a crucial role in establishing ‘Dasan’ as the first domestically developed S. miltiorrhiza variety in South Korea, marking a milestone in the pur- suit of a standardized herbal medicine.
Abstract
Background: Salvia miltiorrhiza Bunge, a perennial medicinal plant belonging to the family Lamiaceae, is native to China and is cultivated in South Korea for its roots. Initially dependent on Chinese imports, recent cultivation advancements have expanded domestic production, however, developed varieties remain lacking. Methods and Results: The best lines were selected from among the offspring in 2010, replicated yield trials (RYT) were conducted in 2014, and local adaptability testing (LAT) was performed in 2015. The ‘Dasan’ line showed beneficial characteristics, including increased emergence rate and superior disease resistance against root rot compared with those of the local variety. Salvianolic acid B and tanshinone IIA were quantified as active ingredients using high performance liquid chromatography: these showed higher levels in ‘Dasan’, than in the local variety indicating its potential as a valuable medicinal variety. Simultaneously the dried root yield was 365 ㎏ per 10 a at four different regions, representing a 125% yield increase compared to that of the local variety. Conclusion: ‘Dasan’ shows promise as a variety of S. miltiorrhiza with superior growth, disease resistance, and high yield potential. This research plays a crucial role in establishing ‘Dasan’ as the first domestically developed S. miltiorrhiza variety in South Korea, marking a milestone in the pur- suit of a standardized herbal medicine.
참고문헌 (30)
- Ai ZL, "Salvia miltiorrhiza extract may exert an antiobesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism", World Journal of Gastroenterology, 28, pp.6131~6156 (2022)
- Ansari MA, "Prospective therapeutic potential of tanshinone IIA: An updated overview", Pharmacological Research, 164, pp.105364~ (2021)
- Bomme U, "Field cultivation of Salvia miltiorrhiza Bunge as a new medicinal plant in Germany, used for the traditional Chinese medicine", Zeitschrift für Arznei-and Gewürzpflanzen, 14, pp.25~31 (2009)
- 장보윤, "단삼 표준화시료의 급성독성에 관한 연구", 생약학회지, 39(4), pp.352~356 (2008), 한국생약학회
- Chen F, "Salvia miltiorrhiza roots against cardiovascular disease : consideration of herb-drug interactions", BioMed Research International, 2017, pp.9868694~ (2017)
- Chen M, "Zhong-danyaozhi No. 1 and Zhongdanyaozhi No. 2 are hybrid varietys of Salvia miltiorrhiza with high yield and active compounds content", Plos One, 11, pp.e0162691~ (2016)
- 최해연, "단삼으로부터 식품부패미생물에 대한 항균성 물질의 분리 및 동정", 한국식품영양과학회지, 32(1), pp.22~28 (2003), 한국식품영양과학회
- Fang ZY, "Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit", Journal of Ethnopharmacology, 115, pp.217~222 (2008)
- Fugh-Berman A, "Herbs and dietary supplements in the prevention and treatment of cardiovascular disease", Preventive Cardiology, 3, pp.24~32 (2000)
- Gong Z, "The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism", Endocrinology, 150, pp.104~113 (2009)
- Jang SI, "Tanshinone IIA from Salvia miltiorrhiza inhibits expression of inducible nitric oxide synthase and production of TNF-α, IL-1β and IL-6 in activated RAW 264. 7 cells", Planta Medica, 69, pp.1057~1059 (2003)
- Jang SI, "Tanshinone IIA inhibits LPS-induced NF-κB activation in RAW 264. 7 cells : Possible involvement of the NIK-IKK, ERK1", 2, p38, and JNK pathways, 2006, pp.542, 1~7
- 정승일, "단삼 유래 Tanshinone IIA가 3T3-L1 세포의 아포토시스 유도와 지방형성 억제에 미치는 영향", 동의생리병리학회지, 23(6), pp.1409~1415 (2009), 한의병리학회
- Ji W, "Hypolipidemic activity and mechanism of purified herbal extract of Salvia miltiorrhiza in hyperlipidemic rats", Journal of Ethnopharmacology, 119, pp.291~298 (2008)
- Kim JC, "Correlation between growth characteristics and root yield in collected peony lines", Korean Journal of Medicinal Crop Science, 6, pp.188~192 (1998)
- Ji Young Kim, "Antioxidant Potential of Dimethyl Lithospermate Isolated from Salvia miltiorrhiza (Red Sage) Against Peroxynitrite", Journal of Medicinal Food, 11(1), pp.21~28 (2008), 한국식품영양과학회
- Kim KS, "Variation of plant characters and correlation analysis of its in Bupleurum falcatum L", Korean Journal of Medicinal Crop Science, 3, pp.71~76 (1995)
- Kim OH, "Anticancer activity of natural products including Salvia miltiorrhiza", Journal of Applied Pharmacology, 7, pp.29~34 (1999)
- 김영국, "단삼의 수확시기에 따른 생육 특성 및 주요 성분 변이", 한국약용작물학회지, 23(5), pp.395~399 (2015), 한국약용작물학회[DOI]
- The Korean pharmacopoeia. The second section of each item in medicine and medical supplies, "Korea Food and Drug Administration(KFDA)", Korea Food and Drug Admini- stration, 25~26 (2012)
- Lee YN, "New flora of Korea(Ⅱ)", pp.376~378 (2006), Kyohaksa corporation
- Lu S., "The Salvia miltiorrhiza Genome", pp.1~15 (2019), Springer
- Final results of the 2021 census of agriculture, forestry and fisheries, "Ministry of Agriculture, Food and Rural Affairs(MAFRA)", Ministry of Agriculture, Food and Rural Affairs, 84~88 (2021)
- Standard method of investigation and analysis for research on the agricultural science and technology, "Rural Development Administration(RDA)", Rural Development Administration, 771~772 (2012)
- "Data by period of agricultural meteorology" (2023)[URL]
- 만효룡, "Salvia Miltiorrhiza Bunge로부터 Tanshinone IIA의 용매추출", Korean Chemical Engineering Research(HWAHAK KONGHAK), 46(4), pp.660~664 (2008), 한국화학공학회
- Wen C, "New cultivars of Salvia miltiorrhiza ‘Danza 1’and ‘Danza 2’", Acta Horticulturae Sinica, 44, pp.2747~2748 (2017)
- Wu YL, "Salvia miltiorrhiza extract and individual synthesized component derivatives induce activating-transcription-factor-3- mediated anti-obesity effects and attenuate obesity-induced metabolic disorder by suppressing C", EBPα in high-fat-induced obese mice, 2022, pp.11, 1022~
- Yang J, "Identification of pathogens causing Salvia miltiorrhiza root rot disease in henan province", Journal of Henan Agricultural Sciences, 50, pp.92~98 (2021)
- Yin HQ, "Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration", Food and Chemical Toxicology, 47, pp.98~103 (2009)