Farfugium japonicum 분획물의 생리활성과 유효성분 분석
Analysis of the Physiological Activity and Composition of Farfugium japonicum Fractions
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Background: This study aimed to compare the bioactive components, antioxidant activity, and anti-enzyme activity of Farfugium japonicum root extracts based on solvent polarity. Methods and Results: F. japonicum roots were extracted using 70% ethanol and fractionated using hexane, methyl chloride, ethyl acetate, and butanol. The ethyl acetate fraction showed the highest total phenol and flavonoid contents as well as strongest antioxidant and enzyme inhibitory activities. High-performance liquid chromatography analysis revealed high levels of caffeic acid in the ethyl acetate fraction and chlorogenic acid in the butanol fraction. Analysis of the hexane frac- tion by gas chromatography-mass spectrometry identified costunolide and benzofuran, which may contribute to its α-glucosidase inhibition. Conclusions: The ethyl acetate fraction of F. japonicum roots exhibited superior antioxidant and enzyme inhibitory activities, likely due to its high caffeic acid content. Meanwhile, α-glucosidase inhibition by the hexane fraction may be attributed to costunolide. These findings highlight the potential of F. japonicum roots as a source of bioactive compounds for functional applications, par- ticularly in antioxidant and enzyme-inhibitory treatments.
Abstract
Background: This study aimed to compare the bioactive components, antioxidant activity, and anti-enzyme activity of Farfugium japonicum root extracts based on solvent polarity. Methods and Results: F. japonicum roots were extracted using 70% ethanol and fractionated using hexane, methyl chloride, ethyl acetate, and butanol. The ethyl acetate fraction showed the highest total phenol and flavonoid contents as well as strongest antioxidant and enzyme inhibitory activities. High-performance liquid chromatography analysis revealed high levels of caffeic acid in the ethyl acetate fraction and chlorogenic acid in the butanol fraction. Analysis of the hexane frac- tion by gas chromatography-mass spectrometry identified costunolide and benzofuran, which may contribute to its α-glucosidase inhibition. Conclusions: The ethyl acetate fraction of F. japonicum roots exhibited superior antioxidant and enzyme inhibitory activities, likely due to its high caffeic acid content. Meanwhile, α-glucosidase inhibition by the hexane fraction may be attributed to costunolide. These findings highlight the potential of F. japonicum roots as a source of bioactive compounds for functional applications, par- ticularly in antioxidant and enzyme-inhibitory treatments.