나노튜브 TiO_2 층 생성 후 전석회화 처리한Ti-6Al-7Nb 합금의 생체활성도
Bioactivity of precalcified nanotubular TiO_2 layer on Ti-6Al-7Nb alloy
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연구 목적:높은 외력이 작용하는 부위의 임플란트 재료로서 사용되고 있는 Ti-6Al-7Nb 합금의 골유착을 개선하기 위한 방법의 하나로서 나노튜브 TiO_2 층 생성하고 전석회화 처리한 다음 유사체액 중에서의 활성도를 알아보고자 하였다. 연구 재료 및 방법:양극산화처리는 glycerol에 20 wt% H_2O와 1 wt% NH4F를 혼합하여 준비한 전해질 수용액에 전압 20 V, 전류밀도 20 mA/㎠의 조건에서 1시간동안 통전하였다. 전석회화처리는 80℃의 Na_2HPO_4 수용액에 30분 동안 침적하고, 이어서100℃의 Ca(OH)_2 포화 수용액에 30분 동안 침적하였으며, 500℃에서 2시간 동안 열처리하였다. 전석회화처리 후 표면층의 생체활성도를 조사하기 위해 36.5℃, pH 7.4의 유사체액에 10일 동안 침적하였다. 결과: 1. 나노튜브 TiO_2 층은 높은 자기정렬 형태를 갖고 큰 직경의 튜브들 사이 공간에 상대적으로 작은 직경의 튜브들이 생성되는 형태로 치밀한 구조를 이루었으며, 상부에서 하부로 갈수록 직경 감소를 보였다. 2. 1 wt% NH4F와 20 wt% H_2O를 함유하는 glycerol 전해액에서 20 V의 전압을 인가하여 생성된 나노튜브들의 평균 길이는 517.0 ± 23.2 nm를 보였다. 3. 나노튜브 TiO_2 층의 생체활성도는 80℃의 0.5 M Na_2HPO_4 수용액과 100℃의 Ca(OH)_2 포화 수용액에 침적하는 전석회화처리 군의 경우에 크게 개선되어, 아파타이트의 석출 과정에서 나타나는 치밀한 돌기상과 이들을 가로지르는 미세 균열상이 관찰되었다. 결론: Ti-6Al-7Nb 합금을 나노튜브 TiO_2 층 생성 후 전석회화 처리한 결과 생체활성도가 개선되었다.
Abstract
PURPOSE: The purpose of this study was to investigate the bioactivity of precalcified nanotubular TiO_2 layer on Ti-6Al-7Nb alloy. MATERIALS AND METHODS: Anodic oxidation was carried out at a potential of 20 V and current density of 20 mA/㎠ for 1 hour. The glycerol solution containing 1 wt% NH4F and 20 wt% deionized water was used as an electrolyte. Precalcification treatment was obtained by soaking in Na_2HPO_4 solution at 80℃ for 30 minutes followed by soaking in saturated Ca(OH)_2 solution at 100℃ for 30 minutes, followed by heat treatment at 500℃ for 2 hours. To evaluate the activity of precalcified nanotubular TiO_2 layer, specimens were immersed in a simulated body fluid with pH 7.4 at 36.5℃ for 10 days. RESULTS: 1. Nanotubular TiO_2 layer showed the highly ordered dense structure by interposing small diameter nanotubes between large ones, the shape of nanotubes was enlarged as going down. 2. The mean length of nanotubes was 517.0 ± 23.2 nm innm glycerol solution containing 1 wt% NH4F and 20 wt% H_2O at 20 V for 1 hour. 3. The bioactivity of Ti-6Al-7Nb alloy was improved with formation of nanotubular TiO_2 layer and precalcification treatment in 80℃ 0.5 M Na_2HPO_4 and saturated 100℃ Ca(OH)_2 solution. CONCLUSION: Bioactivity of precalcified nanotubular TiO_2 layer on Ti-6Al-7Nb alloy was improved.
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