정신분열병에서 사회인지의 개념과 신경생물학
Concept and Neurobiology of Social Cognition in Schizophrenia
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정신분열병 연구에서 사회인지의 중요성은 사회인지가 신경인지와 기능적 예후를 연결하는 징검다리 역할을 한다는 사실에 있다. 다시 말해 사회인지는 정신분열병 환자의 기능적 예후를 예측, 판단하는 중요한 요소이다. 사회인지와 관련 된다고 생각되는 뇌 영역은 연구자들마다 다소간의 논란이 있긴 하지만 주로 전전두엽 특히 배내측 전전두엽, 복내측 전전두엽, 내측 안와 전두엽 등이며 이외에도 편도, 방추 이랑, 위 측두엽 고랑 등이 주로 연구되고 있다. 그 밖에 사회인지와 관련된 신경전달물질로는 옥시토신, 바소프레신, 세로토닌 등이다. 유전적 요인에 대한 연구는 많지 않지만 사회인지에 유전적 요인이 어느 정도 관여하는 것은 확실해 보인다. 향후 사회 인지와 관련하여 뇌기능 영상 및 전기 생리분야의 활발한 연구가 필요하다고 판단된다.
Abstract
Recently, social cognition is becoming a hot issue in field of schizophrenia research. And there are increasing demands for clearer definitions of terms and knowledge about neurobiology of social cognition in schizophrenia. One of the reasons why it has so much attention would be its role of predicting the functional outcomes of schizophrenia patients. The purpose of this article is to review and summarize the concepts and neural correlates of social cognition in schizophrenia. Functional brain imaging studies as well as behavioral studies were also reviewed.
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