본문 바로가기
KERD
논문KCI 등재

정상노인과 경도인지손상 환자에서 수면인자와 신경인지기능의 연관성

Relationship of Sleep Factors with Neurocognitive Function in Normal Elderly Subjects and Mild Cognitive Impairment (MCI) Patients

김기웅|우종인|이동영|추일한|윤종철|김성재|이정희
대한신경정신의학회 (Korean Neuropsychiatric Association)|2007.01|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제46권 제1호|pp. 41-49

2

조회

0

다운로드

4

인용

0

참고문헌

키워드

정상노인·경도인지손상·신경인지기능·주간졸음·수면무호흡증.Normal elderly· MCI· Neurocognitive function· Daytime sleepines· Sleep apnea.
주제분류정신과학

초록

주간졸음의 악화는 지역사회에 거주하는 정상노인뿐 아니라, MCI노인에서 실행기능 감퇴와의 관련성이 시사되며, 수면호흡장애의 위험성은 정상노인에서만 실행기능 감퇴와의 관련성을 보였고, MCI 노인에서는 그 관련성이 시사되지 않았다. 본 연구결과를 토대로, 향후 지역사회 거주하는 정상노인과 MCI 노인에서 객관적 수면검사를 통한 수면장애와 신경인지기능과의 관련성을 비교 분석하는 연구가 뒤따라 할 것으로 생각된다.

Abstract

Objectives：We aimed to compare sleep factors including daytime sleepiness, sleep apnea and insomnia between mild cognitive impairment (MCI) patients and normal control (NC) subjects and to illustrate their relationship with neuropsychological function in the preclinical stage of dementia. Methods：Epworth Sleepiness Scale (ESS), sleep apnea subscale of Sleep Disorders Questionnaire (SA) and questionnaire on insomnia were administered to community-dwelling elderly subjects above the age of 60. Both clinical and neuropsychological batteries of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) assessment packet and Stroop Color and Word Test (SCWT) were done for each subject. Seventy seven NC subjects and 47 MCI patients were selected. Results：In the NC group, ESS scores negatively correlated with Stroop interference (SI) scores. SA scores were negatively correlated with Stroop Color Word (SCW) and SI scores. In the MCI group, ESS scores negatively correlated with SCW scores, and SA scores had no correlation with each neurocognitive function test. Conclusion：Daytime sleepiness was associated with impaired executive function in community-dwelling normal elderly subjects and MCI patients. But the higher risk of SA was associated with decreased executive function only in normal elderly subjects. (J Korean Neuropsychiatr Assoc 2007;46(1):41-49)

참고문헌 (43)

  1. Gauthier S, "Mild cognitive impairment is not a clinical entity and should not be treated.", 62, pp.1164~1166 (2005)
  2. Foley DJ, "Sleep complaints among elderly persons: an epidemio-logic study of three comunities.", 18, pp.425~432 (1995)
  3. Cohen-Zion M, "Changes in cognitive function associated with slep disordered breathing in older people.", 49, pp.1622~1627 (2001)
  4. Foley D, "Daytime sleepiness is asociated with 3-year incident dementia and cognitive decline in older Japanese-American men.", 49, pp.1628~1632 (2001)
  5. "Bliwise DL. Is sleep apnea a cause of reversible dementia in old age", pp.1407~1419
  6. Phillips BA, "Cook YR. Sleep-disordered breathing in the healthy elderly. Clinically significant", pp.345~349
  7. Petersen RC, "Mild cognitive impairment: clinical characterization and outcome", 56, pp.303~308 (1999)
  8. Anne D, "Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test batery.", 23, pp.1~13 (2003)
  9. Bedard MA, "pathogenesis of neuropsychological deficits. J Clin Exp Neuropsychol 1991", pp.950~964
  10. Naegele B, "Deficits of cognitive executive functions in patients with sleep apnea syndrome.", 18, pp.43~52 (1995)
  11. Mason WJ, "Kaplan O. Slep-disordered breathing in comunity-dweling elderly. Slep 1991", pp.486~495
  12. Hoch CC, "Stack JA. Sleep disordered breathing in normal and pathologic aging. J Clin Psychiatry 1986", pp.499~503
  13. Macey P, "Brain morphology asociated with obstructive sleep apnea.", 166, pp.1382~1387 (2002)
  14. Chen P, "Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented.", 55, pp.1847~1853 (2000)
  15. Alchanatis M, "Frontal brain lobe impairment in obstructive sleep ap-noea: a proton MR spectroscopy study.", 24, pp.980~986 (2004)
  16. Asplund R, "Daytime sleepiness and napping amongst the elderly in relation to somatic health and medical treatment.", 239, pp.261~267 (1996)
  17. Klink M, "Quan SF. Prevalence of reported sleep disturbances in a ge-neral adult population and their relationship to obstructive airways di-seases. Chest 1987", pp.540~546
  18. Cho MJ, "Va-lidation of Geriatric Depression Scale, Korean Version (GDS) in the Assessment of DSM-I-R Major Depression.", 38, pp.48~63 (1999)
  19. Saunders JB, "Grant M. Develop-ment of the Alcohol use disorders identification test WHO colaborative project on early detection of persons with harmful al-cohol consumption II. Adiction 1993", pp.791~804
  20. Le JH, "Deve-lopment of the Korean version of the Consortium to Establish a Regi-stry for Alzheimers Disease Assessment Packet (CERAD-K): clini-cal and neuropsychological assesment batteries.", 57, pp.47~53 (2002)
  21. Petersen RC, "Mild cognitive impairment: clinical characterization and out-come.", 56, pp.303~308 (1999)
  22. American Psychiatric Asociation, "Diagnostic and Statistical Manual of Mental disorders.", pp.Washington, DC: American Psychiatric Asociation.~ (2000)
  23. The Epworth Sleepiness Scale. Sleep 1991, "Muray W. A new for measuring daytime sleepiness", pp.540~545
  24. Douglas AB, "creation and mul-tivariate structure of SDQ. Slep 194", ni(-murcia g), pp.160~167
  25. Parker L, "Kripke DF. De-mentia in institutionalized elderly relation to sleep apnea. J Am Geri-atr Soc 1991", pp.258~263
  26. Yesavage JA, "Dement WC. Sleep apnea in Alzheimers disease. Neurobiol Aging 1989", pp.343~346
  27. Saunders NA, "Mant A. sleep and breathing in the elderly. In", pp.1993673~693
  28. Turkington PM, "Prevalence and predictors of upper airway obstruction in the first 24 hours after acute stroke.", 33, pp.2037~2042 (2002)
  29. Adams N, "Relation of measures of slep-disordered breathing to neuropsychological functioning.", 163, pp.1626~1631 (2001)
  30. Redline S, "Neuropsychological function in mild slep-disordered breathing.", 20, pp.160~167 (1997)
  31. Young T, "Bader S. The ocurence of sleep disordered breathing in middle-aged adults. N Engl J Med 1993", pp.1230~1235
  32. Kim HC, "Slep-disordered breathing and neuropsychological deficits: a popu-lation-based study.", 156, pp.1813~1819 (1997)
  33. Dealberto MJ, "Breathing disor-ders during sleep and cognitive performance in an older comunity sample: the EVA Study.", 44, pp.1287~1294 (1996)
  34. Verstraeten E, "Executive control of attention in sleep apnea patients: theoretical concepts and methodological considerations.", 8, pp.257~267 (2004)
  35. Bonanni E, "Daytime sleepiness in mild and moderate Alzheimers disease and its relationship with cognitive impairment.", 14, pp.311~317 (2005)
  36. Wenk GL, "Neuropathologic changes in Alzheimers disease.", 64, pp.7~10 (2003)
  37. LaBerge D, "Atentional processing: the brains art of mindfulnes." (1995), Cambridge MA, Harvard University Pres
  38. Dorsey CM, "Spectroscopy before and after total slep deprivation in healthy adult men.", 23, pp.357~358 (2000)
  39. Asada T, "Asocia-tions between retrospectively recalled napping behavior and later development of Alzheimers disease: association with APOE genoty-pes.", 23, pp.629~634 (2000)
  40. Ganguli M, "Prevalence and persistence of sleep complaints in a rural older community sample: the MoVIES pro-ject.", 44, pp.778~784 (1996)
  41. Stone J, "Mercer J. Neuropsy-chological functioning in older insomniacs with or without obstruc-tive sleep apnea. Psychol Aging 1994", pp.231~236, Morin CM
  42. Nykamp K, "Repeated nocturnal sleep latencies in narcoleptic, sleepy and alert subjects.", 110, pp.1531~1534 (1999)
  43. J.H. Le, "MCI환자의 수면인자와 신경인지기능", 46(1), pp.49~ (2007)

관련 논문AI추천

경도인지손상 환자에서 수면각성리듬과 신경인지기능의 연관성김성재, 김태희, 안경진, 이정희, 주진형대한신경정신의학회 · 신경정신의학2009 · 제48권 제6호주간졸음을 호소하는 노인에서 수면변인과 신경인지기능 세부영역과의 연관성김성재, 양정희, 이정현, 이정희, 황현국대한신경정신의학회 · 신경정신의학2007 · 제46권 제6호경도인지장애 환자의 수면무호흡증과 주의력 결함 및 전두엽 실행기능 특성곽호완, 김혜민, 이호원, 장문선한국임상심리학회 · Korean Journal of Clinical Psychology2011 · 제30권 제1호경도인지장애 환자에서 수면문제와 인지저하의 연관성김성완, 김재민, 신일선, 신희영, 윤진상, 임찬영대한생물치료정신의학회 · 생물치료정신의학2016 · 제22권 제3호경도인지손상 환자에서 야간수면과 전두엽기능의 연관성김성재, 이정희, 정재석, 주진형대한신경정신의학회 · 신경정신의학2008 · 제47권 제3호기억 장애 환자에서 수면의 질과 인지기능과의 관련성이화령, 주은연, 진주희, 최수정대한수면연구학회 · Journal of sleep medicine2020 · 제17권 제2호

이 간행물의 다른 논문 (12건)

2007 World Psychiatric Association Regional Meeting 을 준비하며권준수pp. 3-4한국인 알코올 의존 자녀들과 도파민 D2, D4 수용체, GABAA 수용체 β Subunit 및 세로토닌 운반체 유전자 다형성 사이의 연관성에 대한 예비적 연구남궁기, 전진용, 천근아, 김재원, 이준영pp. 5-12흰쥐에서 출생 전의 Nitric Oxide Synthase 억제제의 노출이 출생 후의 MK-801에 의해 유도된 행동 민감성에 미치는 영향김길중, 박숙현, 정영인pp. 13-18정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 에비연구송지연, 권준수, 하태현, 이승재, 이경진, 김성년, 이애라, 위휘, 강도형, 유소영pp. 19-28내인성 혈장 리튬 농도와 정신분열병이병학, 김성재, 윤재항, 오채근, 김종인, 김창현pp. 29-34
원문 보기