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주간졸음을 호소하는 노인에서 수면변인과 신경인지기능 세부영역과의 연관성

Relationship of Sleep Parameters with Neurocognitive Function in the Elderly with Excessive Daytime Sleepiness (EDS)

황현국|김성재|이정희|양정희|이정현
대한신경정신의학회 (Korean Neuropsychiatric Association)|2007.11|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제46권 제6호|pp. 552-559

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참고문헌

키워드

과다주간졸음·신경인지기능·수면변인.Excesive daytime sleepiness· Neurocognitive function· Sleep parameter.
주제분류정신과학

초록

본 연구의 주간졸음을 호소하는 노인에서 주간졸음 정도나 수면 중 호흡장애의 관련 변인들은 인지기능감퇴와의 관련성을 적절히 반영치 못하였으나 야간수면의 질저하가 언어기능, 기억력 및 실행기능과 같은 특정 인지기능 감퇴와의 관련성을 보여주었다.

Abstract

Objectives：Excessive daytime sleepiness (EDS) in the elderly is related to cognitive dysfunction. We aimed to analyze the difference in the neurocognitive function between the elderly groups with and without EDS and examine the correlation between sleep parameters and the neurocognitive function in the elderly with EDS. Methods：Thirty seven subjects who visited Kangwon National University Hospital were recruited. We excluded those who had abnormalities in laboratory examination or chronic systemic diseases. For each subject, a neuropsychological battery in the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) Assessment Packet was applied. Nocturnal polysomnographies were conducted in 16 subjects with EDS. Results：There were no significant differences in the neurocognitive function between EDS positive and EDS negative groups. In the EDS positive group, the amount of stage 1 sleep negatively correlated with scores on Boston naming test, word list memory and Stroop interference, respectively (r=-0.611, -0.583, -0.611). Also, REM sleep amount positively correlated with scores of word list recognition (r=0.568), and limb movement index negatively correlated with scores of word list memory (r=-0.523). Conclusion：The poor sleep quality was associated with impaired language, memory and executive functions. Also, increased limb movements were associated with the memory decline. (J Korean Neuropsychiatr Assoc 2007;46(6):552-559)

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