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경도인지손상 환자에서 수면각성리듬과 신경인지기능의 연관성

Relationship of Neurocognitive Function with the Sleep-Wake Rhythm in Mild Cognitive Impairment(MCI) Patients

김태희|김성재|이정희|주진형|안경진
대한신경정신의학회 (Korean Neuropsychiatric Association)|2009.12|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제48권 제6호|pp. 446-452

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참고문헌

키워드

경도인지손상·수면각성리듬·신경인지기능MCI·Sleep-wake rhythm·Neurocognitive function
주제분류정신과학

초록

MCI군은 정상노인군에 비해 수면유지가 어려웠고 수면 중 움직임이 심하였으나 수면각성리듬의 진폭과 정점시각은 유의한 차이가 없었다. 양군을 합한 전체군에서는 수면각성 리듬의 진폭 감소가 치매의 예측인자로 알려진 시공간능력 감퇴와의 연관성을 보여주었다. 향후 MCI군의 확충을 통한 연구에서 본 연구의 결과를 확인하는 과정이 필요할 것으로 여겨진다.

Abstract

Objectives: We compared the parameters of the sleep-wake rhythm in mild cognitive impairment (MCI) patients to those of normal elderly subjects, to illustrate how the characteristics of circadian rhythm relate to a specific neurocognitive function. Methods: We selected 12 MCI patients and 12 age- and sex-matched normal control (NC) subjects and administered the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K) Neuropsychological battery and Stroop Color-Word Test (SCWT) to each subject. We measured each subject's sleep-wake rhythm by applying actigraphy for 96 hours. The sleep-wake rhythm was examined by cosinor analysis. Results: There was no significant difference in the amplitude or acrophase of the sleep-wake rhythms between the NC and MCI groups. In the combined group, amplitude was positively correlated with Constructional Praxis scores (r=0.434, p<0.05), and acrophases tended to be positively correlated with Word List Memory scores (r=0.370, p=0.07). Conclusion: There was no difference between MCI patients’ sleep-wake rhythm’s amplitude and acrophase and those of NC subjects. Furthermore, decreased amplitude was associated with impaired visuospatial function in the combined group. It will be necessary to confirm this result in an expanded MCI group in a future study.

참고문헌 (37)

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