본문 바로가기
KERD
논문KCI 등재

전수면박탈이 정상인의 생리기능과 인지기능에 미치는 영향

The Effect of Total Sleep Deprivation on the Physiological and Cognitive Function

홍승철|신윤경|한진희|송후림|이성필|정종현
대한신경정신의학회 (Korean Neuropsychiatric Association)|2007.11|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제46권 제6호|pp. 539-545

1

조회

0

다운로드

2

인용

0

참고문헌

키워드

수면 박탈·생리기능·인지기능·전산화 신경인지기능 검사.Slep deprivation· Physiological function· Neurocognitive function·
주제분류정신과학

초록

본 연구는 혈액학적 검사 및 전산화 신경인지기능 검사를 이용하여 수면박탈이 인체의 생리기능 및 인지기능에 미치는 영향에 대하여 알아보고자 하였다. 수면주기에 이상이 없는 건강한 자원자 16명을 대상으로 한 48시간의 전수면박탈은 갑상선호르몬의 농도를 증가시켰으며 백혈구 수치가 상승하였다. 혈액화학검사에서 비록 정상범위 내에서의 변화이기는 하지만, 간담도계의 기능과 관련된 total protein, albumin, alkaline phosphatase, total bilirubin 수치가 유의하게 변화되어 수면박탈의 간담도계 대사에 대한 영향을 시사하였다. 또한 수면박탈에 의해 판단능력, 정보처리속도, 반응행동 능력이 저하되고, 단순주의력, 각성도 유지능력도 부분적으로 저하됨이 확인되었다.

Abstract

Objectives：Purpose of this study was to investigate physiological and neurocognitive effects of total sleep deprivation by using laboratory blood tests and the computerized neurocognitive function test in healthy subjects. Methods：Sixteen healthy volunteers participated in this study. Subjects were recommended to remain awake for 48 hours under continuous surveillance. Lab tests of cortisol, prolactin, thyroid hormone, growth hormone, and immunoglobulin (IgG, IgA, IgM, IgD, IgE), CBC, BC and the Vienna test were performed before and after 48 hours of total sleep deprivation. Results：Concentration of T3 and T4 significantly increased after deprivation. In the reaction test, distribution reaction time significantly increased, and correct reaction significantly decreased. In the vigilance test, amount of correct reaction significantly decreased, and the mean value of correct reaction time was significantly delayed. Level of fasting blood sugar, total protein, albumin, alkaline phosphatase and potassium significantly increased, respectively, except for the level of total bilirubin which was decreased. After total sleep deprivation, WBC counts significantly increased. Regarding immunoglobulin level, IgG, IgA and Ag M concentrations appeared to decrease, but the results were not statistically significant. Conclusion：The effect of total sleep deprivation on physiological function was significant in the level of thyroid hormone. Although statistically not significant, the results of growth hormone and the immune system showed a trend in relations to the effect of total sleep deprivation. Results of blood chemistry suggest that sleep deprivation may influence metabolism of hepatobiliary system. Cognitive impairment was also seen in reactive and vigilant functions after total sleep deprivation. (J Korean Neuropsychiatr Assoc 2007;46(6):539-545)

참고문헌 (39)

  1. Dement WC, "Sleep extension: getting as much extra sleep as possible", 24, pp.251~268 (2005)
  2. Sinha AK, "Enzyme activity in sleep and sleep deprivation", pp.957~960
  3. Fiziol Zh SSSR Im I M Sechenova 1979; 65, "Denaturation changes in the proteins of the membrane structures of the brain during deprivation of the para-doxical stage of sleep", pp.23~28
  4. Farber J, "Dopamine meta-bolism and receptor sensitivity in rat brain after REM slep deprivation", pp.509~513
  5. Opp MR, "Cytokines and sleep", 9, pp.355~364 (2005)
  6. Haack M, "Efects of sleep on endotoxin-induced host responses in healthy men", 63, pp.568~578 (2001)
  7. Biliards SS, "Endotoxin increases sleep and brain alopregnanolone concentrations in newborn lambs", 52, pp.892~899 (2002)
  8. Schuld A, "Experimental studies on the interaction betwen slep and the immune system in humans", 55, pp.29~35 (2005)
  9. Everson CA, "Functional consequences of sustained sleep deprivation in the rat", 69, pp.43~54 (1995)
  10. Rechtschafen A, "Slep deprivation in the rat: an update of the 1989 paper", 25, pp.18~24 (2002)
  11. Everson CA, "Clinical asesment of blod leukocytes, serum cytokines, and serum imunoglobulins as responses to slep deprivation in laboratory rats", 289, pp.1054~1063 (2005)
  12. David MM, "Thyroid function and response to 48-hour sleep depriva-tion in treatment-resistant depressed patients", 48, pp.323~326 (2000)
  13. Parker DC, "Efects of slow wave sleep deprivation on human growth hor-mone release in sleep", pp.299~307
  14. Everson CA, "Reductions in circulating anabolic hor-mones induced by sustained sleep deprivation in rats", 286, pp.1060~1070 (2004)
  15. Ruskin DN, "Slep de-privation impairs hippocampus-mediated contextual learning but not amygdala-mediated cued learning in rats", 19, pp.3121~3124 (2004)
  16. Guan Z, "Slep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus", 1018, pp.38~47 (2004)
  17. Shapiro CM, "a recovery period after exercise", pp.1253~1254
  18. Horne JA, "Sleep and sleepiness folowing a behaviouraly", 46(6)
  19. Rowland LM, "Oculomotor responses during partial and total sleep deprivation", 76, pp.104~113 (2005)
  20. Otmani S, "Efect of driving duration and partial sleep deprivation on subsequent alertness and performance of car drivers", 13(84), pp.715~724 (2005)
  21. Whelihan WM, "The relationship of neuro-psychological functioning to driving competence in older persons with early cognitive decline", 20, pp.217~228 (2005)
  22. Anstey KJ, "Cognitive, sensory and physical factors enabling driving safety in older adults", 25, pp.45~65 (2005)
  23. Borbely AA, "Slep Homeostasis and Models of Sleep Regulation, Principle and Practice of Sleep Medicine, 4th ed", pp.405~417 (2005), New-York: W.B. Saunders Company
  24. Copinschi G, "Metabolic and endocrine effects of sleep deprivation", 6, pp.341~347 (2005)
  25. Ozturk L, "Efects of 48 hours sleep deprivation on human imune profile", 24, pp.107~110 (1999)
  26. Boyum A, "The effect of strenuous exercise, calorie deficiency and sleep deprivation on white blood cells, plasma imunoglobulins and cytokines", 43, pp.228~235 (1996)
  27. Heiser P, "White blod cels and cortisol after sleep deprivation and recovery sleep in humans", 250, pp.16~23 (2000)
  28. Dinges DF, "Leukocytosis and natural killer cel function paralel neurobehavioral fatigue induced by 64 hours of sleep de-privation"
  29. Rugeri P, "Enhanced sympathetic reactivity asociates with insulin resistance in young zucker rat", 291, pp.R376~R382 (2006)
  30. Helmreich DL, "Relation between the hypothalamic-pituitary-thyroid (HPT) axis and the hypo-thalamic-pituitary-adrenal (HPA) axis during repeated stress", 81, pp.183~192 (2005)
  31. Steiger A, "Sleep and endocrine regulation", 8, pp.358~376 (2003)
  32. von Treuer K, "Overnight human plasma melatonin, cortisol, prolactin, TSH, under conditions of normal slep, sleep deprivation, and sleep recovery", 20, pp.7~14 (1996)
  33. Obal F Jr, "GHRH and sleep", 8, pp.367~377 (2004)
  34. Bonuck K, "Growth failure and sleep disordered breathing: a review of the literature", 70, pp.769~778 (2006)
  35. Lee HJ, "The Effects of Total Sleep Deprivation on Neurocognitive Functions", 38, pp.480~490 (1999)
  36. Pilcher JJ, "Effects of sleep deprivation on performance: a meta-analysis", 19, pp.318~326 (1996)
  37. Ford CV, "a study of sleep", pp.1435~1442
  38. Storer JS, "Effects of sleep deprivation on cognitive ability and skills of pediatrics residents", pp.29~32
  39. Storer JS, "Effects of sleep deprivation on cognitive ability and skills of pediatrics residents", pp.29~32

관련 논문AI추천

수면 박탈이 주간 졸음 및 피로감과 집중력에 미치는 영향김정란, 신석철, 왕성근, 이규일대한생물치료정신의학회 · 생물치료정신의학2001 · 제7권 제2호Adverse Effects of 24 Hours of Sleep Deprivation on Cognition and Stress Hormones구대림, 김대영, 주은연, 홍승봉, Cindy W Yoon대한신경과학회 · Journal of Clinical Neurology2012 · 제8권 제2호수면박탈이 주간 시간대별 졸리움에 미치는 영향배경도, 왕성근대한생물치료정신의학회 · 생물치료정신의학1998 · 제4권 제2호한 남자에서 수면 박탈 시 cDNA Microarray 분석에 의한 유전자 발현김종우, 정영철, 정주호, 홍미숙대한생물치료정신의학회 · 생물치료정신의학2003 · 제9권 제2호수면 박탈에 의한 인지기능 장애에 대한 카페인의 효과김형섭, 왕성근대한생물치료정신의학회 · 생물치료정신의학2005 · 제11권 제1호1일 완전수면박탈 후 주간 졸음에 대한 Modafinil의 효과이준, 왕성근, 이동준, 이태경대한생물치료정신의학회 · 생물치료정신의학2009 · 제15권 제1호

이 간행물의 다른 논문 (11건)

지연성 수면위상증후군 청소년에서 기상 시 어려움과 주간 졸림에 대한 Dawn Simulation 효과 연구강시현, 유한익, 김창윤, 윤인영, 안준호, 왕희령, 정석훈pp. 546-551주간졸음을 호소하는 노인에서 수면변인과 신경인지기능 세부영역과의 연관성이정현, 황현국, 양정희, 이정희, 김성재pp. 552-559노년기 주관적 기억력 감퇴의 예측인자 : 한국인의 건강과 노화에 관한 종적 연구 결과노현아, 도연자, 유지민, 이동영, 정지운, 최진영, 김기웅, 우종인, 최은애, 박영선, 박준혁, 이석범pp. 560-565사회적 음주자에서 매운 맛 선호도가 급성 음주 반응에 대한 Naltrexone 효과에 미치는 영향정희정, 박숙현, 강철중, 김성곤, 김종현pp. 566-572양극성 장애에서 표피성장인자의 유전적 다형성에 대한 연합연구김용식, 이규영, 주은정, 강웅구, 안용민, 김수경pp. 573-578
원문 보기