Adverse Effects of 24 Hours of Sleep Deprivation on Cognition and Stress Hormones
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Background and Purpose The present study was designed to investigate whether 24 h of SD negatively affects the attention and working memory and increases the serum concentrations of stress hormones, glucose, and inflammatory markers. Methods The acute effects of sleep deprivation (SD) on cognition and the stress hormones were evaluated in six healthy volunteers (all men, age 23-27 years). All were good sleepers, had no history of medical or neuropsychiatric diseases, and were not taking any kind of medication. All of the volunteers were subjected to the Continuous Performance Test (CPT) for attention and working memory of cognition and blood tests both before and after 24 h of SD. Electroencephalographic monitoring was performed during the study to confirm the wakefulness of the subjects. Results SD significantly elevated the serum concentrations of stress hormones (cortisol, epinephrine, and norepinephrine), but serum levels of glucose and inflammatory markers were not changed compared to baseline. For easier steps of the CPT the subjects performed well in giving correct responses after SD; the correct response scores decreased only at the most difficult step of the CPT. However, the subjects performed consistently poor for the error responses at all steps after SD. There was no correlation between the CPT scores and stress hormone levels. Conclusions The 24 h of SD significantly heightened the levels of stress hormones and lowered attention and working memory. The acute SD condition seems to render the subject more susceptible to making errors.
Abstract
Background and Purpose The present study was designed to investigate whether 24 h of SD negatively affects the attention and working memory and increases the serum concentrations of stress hormones, glucose, and inflammatory markers. Methods The acute effects of sleep deprivation (SD) on cognition and the stress hormones were evaluated in six healthy volunteers (all men, age 23-27 years). All were good sleepers, had no history of medical or neuropsychiatric diseases, and were not taking any kind of medication. All of the volunteers were subjected to the Continuous Performance Test (CPT) for attention and working memory of cognition and blood tests both before and after 24 h of SD. Electroencephalographic monitoring was performed during the study to confirm the wakefulness of the subjects. Results SD significantly elevated the serum concentrations of stress hormones (cortisol, epinephrine, and norepinephrine), but serum levels of glucose and inflammatory markers were not changed compared to baseline. For easier steps of the CPT the subjects performed well in giving correct responses after SD; the correct response scores decreased only at the most difficult step of the CPT. However, the subjects performed consistently poor for the error responses at all steps after SD. There was no correlation between the CPT scores and stress hormone levels. Conclusions The 24 h of SD significantly heightened the levels of stress hormones and lowered attention and working memory. The acute SD condition seems to render the subject more susceptible to making errors.
참고문헌 (22)
- Nilsson JP, "Less effective executive functioning after one night’s sleep deprivation", J Sleep Res, 14, pp.1~6 (2005)
- Adam M, "Age-related changes in the time course of vigilant attention during 40 hours without sleep in men", Sleep, 29, pp.55~57 (2006)
- Leproult R, "Sleep loss results in an elevation of cortisol levels the next evening", Sleep, 20, pp.865~870 (1997)
- Spiegel K, "Impact of sleep debt on metabolic and endocrine function", Lancet, 354, pp.1435~1439 (1999)
- 류선영, "Measurement of Precuneal and Hippocampal Volumes Using Magnetic Resonance Volumetry in Alzheimer’s Disease", Journal of Clinical Neurology, 6(4), pp.196~203 (2010), 대한신경과학회
- Diamond DM, "Psychological stress repeatedly blocks hippocampal primed burst potentiation in behaving rats", Behav Brain Res, 62, pp.1~9 (1994)
- Conners CK, "Conners’ Continuous Performance Test II: Computer Program for Windows Technical Guide and Software Manual. North Tonawanda" (2000), Multi-Health Systems
- Hoddes E, "Quantification of sleepiness: a new approach", Psychophysiology, 10, pp.431~436 (1973)
- Wilkinson RT, "Sleep deprivation: performance tests for partial and selective sleep deprivation", Prog Clin Psychol, 8, pp.28~43 (1968)
- Whitney P, "Measurement of cognition in studies of sleep deprivation", Prog Brain Res, 185, pp.37~48 (2010)
- Hagewoud R, "A time for learning and a time for sleep: the effect of sleep deprivation on contextual fear conditioning at different times of the day", Sleep, 33, pp.1315~1322 (2010)
- de Quervain DJ, "Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe", Eur J Neurosci, 17, pp.1296~1302 (2003)
- Lupien SJ, "Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans", Behav Neurosci, 113, pp.420~430 (1999)
- Wolf OT, "Cortisol differentially affects memory in young and elderly men", Behav Neurosci, 115, pp.1002~1011 (2001)
- Koenigs M, "Left dorsomedial frontal brain damage is associated with insomnia", J Neurosci, 30, pp.16041~16043 (2010)
- Altena E, "Reduced orbitofrontal and parietal gray matter in chronic insomnia: a voxel-based morphometric study", Biol Psychiatry, 67, pp.182~185 (2010)
- Gangwisch JE, "Sleep duration as a risk factor for diabetes incidence in a large U.S. sample", Sleep, 30, pp.1667~1673 (2007)
- Mallon L, "High incidence of diabetes in men with sleep complaints or short sleep duration: a 12-year follow-up study of a middle-aged population", Diabetes Care, 28, pp.2762~2767 (2005)
- Schmid SM, "Disturbed glucoregulatory response to food intake after moderate sleep restriction", Sleep, 34, pp.371~377 (2011)
- Mullington JM, "Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation", Prog Cardiovasc Dis, 51, pp.294~302 (2009)
- Knutson KL, "The metabolic consequences of sleep deprivation", Sleep Med Rev, 11, pp.163~178 (2007)
- Frey DJ, "The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults", Brain Behav Immun, 21, pp.1050~1057 (2007)