신경인지검사 성적의 개인 내 변산성 : 조현병 환자, 형제자매 및 대조군 비교
Intra-Individual Neuropsychological Test Variability : A Comparison of Patients with Schizophrenia, Their Siblings, and Healthy Controls
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
본 연구는 조현병과 관련되어 나타나는 인지기능 결함을확인하였다. 환자군은 인지 영역간의 개인 내 변산성이 크게나타나 수행의 불균형이 두드러졌으며 특히 유병기간이 11년 이상으로 만성화된 환자일수록 개인 내 변산성이 큰 것으로 나타났다. 또한 다른 인지 영역과 달리 처리 속도 영역에서만 소검사 간 개인 내 변산성은 환자, 형제자매, 대조군순서로 크고 환자들도 유병기간이 길어질수록 큰 것으로 나타났다. 이러한 인지적 특성이 조현병 환자의 인지기능을 이해하는 데 도움을 줄 것으로 생각된다.
Abstract
Objectives Intra-individual variability of cognitive performance across different tests or domains has been reported as an important index of cognitive function. The aim of the current study is to examine the intra-individual variability across different cognitive domains and tests in patients with schizophrenia, their unaffected siblings, and normal controls. We also compared the variability among three patient sub-groups divided according to the duration of illness. Methods Comprehensive neurocognitive tests were administered in order to stabilize patients with schizophrenia (n=129), healthy siblings (n=38) of the patients, and normal controls (n=110). Intra-individual variability was computed from the variance of the scores of six cognitive domains of the Measurement and Treatment Research to Improve Cognition in Schizophrenia consensus battery. We examined intra-individual variability across six factor-based cognitive scores and individual test scores of each cognitive domain. Results Compared to the normal control and sibling groups, patients showed significantly increased intra-individual variability across six cognitive domains and individual cognitive tests of each domain. Compared to the normal control, siblings showed significantly increased intra-individual variability only across individual tests of the processing of speed domain. Among patient sub-groups, those with the longest duration of illness (≥11 years) showed significantly higher intra-individual variability across six cognitive domains and across individual tests of the processing of speed domain compared to the other two groups. Conclusion This study identified cognitive dissonances across six cognitive domain schizophrenia patients. These cognitive characteristics were not observed in the sibling groups and seemed to progress during the course of illness.
참고문헌 (39)
- Heaton RK, "Stability and course of neuropsychological deficits in schizophrenia", Arch Gen Psychiatry, 58, pp.24~32 (2001)
- Nam HJ, "Cognitive profiles of healthy siblings of schizophrenia patients: application of the cognitive domains of the MATRICS consensus battery", World J Biol Psychiatry, 10(4 Pt 2), pp.452~460 (2009)
- Dollfus S, "Executive", attentional cognitive functions in schizophrenic patients and their parents: a preliminary study, 2002, pp.53, 93~99
- Saoud M, "Neuropsychological deficit in siblings discordant for schizophrenia", Schizophr Bull, 26, pp.893~902 (2000)
- Hill SK, "Neuropsychological profiles delineate distinct profiles of schizophrenia, an interaction between memory and executive function, and uneven distribution of clinical subtypes", J Clin Exp Neuropsychol, 24, pp.765~780 (2002)
- Snitz BE, "Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes", Schizophr Bull, 32, pp.179~194 (2006)
- Cole VT, "Intra-individual variability across neuropsychological tasks in schizophrenia: a comparison of patients, their siblings, and healthy controls", Schizophr Res, 129, pp.91~93 (2011)
- Rentrop M, "Intra-individual variability in high-functioning patients with schizophrenia", Psychiatry Res, 178, pp.27~32 (2010)
- Roalf DR, "Neurocognitive performance stability in a multiplex multigenerational study of schizophrenia", Schizophr Bull, 39, pp.1008~1017 (2013)
- MacDonald SW, "Intra-individual variability in behavior: links to brain structure, neurotransmission and neuronal activity", Trends Neurosci, 29, pp.474~480 (2006)
- Hultsch DF, "Variability in reaction time performance of younger and older adults", J Gerontol B Psychol Sci Soc Sci, 57, pp.P101~P115 (2002)
- Olch DR, "Psychometric pattern of schizophrenics on the Wechsler-Bellevue intelligence test", J Consult Psychol, 12, pp.127~136 (1948)
- Trehub A, "Wechsler-Bellevue scatter as an index of schizophrenia", J Consult Psychol, 22, pp.147~149 (1958)
- Erlenmeyer-Kimling L, "Neurobehavioral deficits in offspring of schizophrenic parents: liability indicators and predictors of illness", Am J Med Genet, 97, pp.65~71 (2000)
- Ott SL, "The New York High-Risk Project: social and general intelligence in children at risk for schizophrenia", Schizophr Res, 31, pp.1~11 (1998)
- Bilder RM, "Intellectual deficits in first-episode schizophrenia: evidence for progressive deterioration", Schizophr Bull, 18, pp.437~448 (1992)
- Weinberger DR, "Implications of normal brain development for the pathogenesis of schizophrenia", Arch Gen Psychiatry, 44, pp.660~669 (1987)
- Rund BR, "A review of longitudinal studies of cognitive functions in schizophrenia patients", Schizophr Bull, 24, pp.425~435 (1998)
- Guy W, "ECDEU assessment manual for psychopharmacology" (1976), National Institute of Mental Health (US) Psychopharmacology Research Branch
- 노지혜, "Factor Structure of the Neurocognitive Tests: An Application of the Confirmative Factor Analysis in Stabilized Schizophrenia Patients", Journal of Korean Medical Science, 25(2), pp.276~282 (2010), 대한의학회
- Holtzer R, "Within-person across-neuropsychological test variability and incident dementia", JAMA, 300, pp.823~830 (2008)
- Shin YS, "Increased intra-individual variability of cognitive processing in subjects at risk mental state and schizophrenia patients", PLoS One, 8, pp.e78354~ (2013)
- Hultsch DF, "Intraindividual variability in cognitive performance in older adults:comparison of adults with mild dementia, adults with arthritis, and healthy adults", Neuropsychology, 14, pp.588~598 (2000)
- Murtha S, "Increased variability accompanies frontal lobe damage in dementia", J Int Neuropsychol Soc, 8, pp.360~372 (2002)
- Vaurio RG, "Increased intra-individual reaction time variability in attention-deficit", hyperactivity disorder across response inhibition tasks with different cognitive demands, 2009, pp.47, 2389~2396
- Castellanos FX, "Varieties of attention-deficit", hyperactivity disorder-related intra-individual variability, 2005, pp.57, 1416~1423
- Hughes C, "Cognitive functioning in siblings discordant for schizophrenia", Acta Psychiatr Scand, 111, pp.185~192 (2005)
- Chen YL, "Semantic verbal fluency deficit as a familial trait marker in schizophrenia", Psychiatry Res, 95, pp.133~148 (2000)
- Cannon TD, "Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers", Arch Gen Psychiatry, 51, pp.651~661 (1994)
- Bonner-Jackson A, "Neurocognition in schizophrenia: a 20-year multi-follow-up of the course of processing speed and stored knowledge", Compr Psychiatry, 51, pp.471~479 (2010)
- Kliegel M, "MMSE cross-domain variability predicts cognitive decline in centenarians", Gerontology, 50, pp.39~43 (2004)
- Dickinson D, "General and specific cognitive deficits in schizophrenia: Goliath defeats David?", Biol Psychiatry, 64, pp.823~827 (2008)
- Gold S, "Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia", Am J Psychiatry, 156, pp.1342~1348 (1999)
- Yeom T, "K-Wechsler Adult Intelligence Scale" (1992), Korea Guidance
- "Development of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries", J Gerontol B Psychol Sci Soc Sci, 57, pp.P47~P53 (2002)
- Kang Y, "Brief Report: a normative study of the Korean version of Controlled Oral Word Association Test (COWAT) in the elderly", Korean J Clin Psychol, 19, pp.385~392 (2005)
- Kim H, "Assessment of memory disorders" (2001), Neuropsy
- Nuechterlein KH, (1999), Authors
- Asarnow RF, "Directions for Use of the UCLA Span of Apprehension Program, Version 3.5 for Arrays 3 and 12 Letters, on IBM AT and Fully Compatible Microcomputers" (1994), UCLA Department of Psychiatry and Biobehavioral Sciences