조현병 환자와 발병하지 않은 일차친족에서 인지조절 결함의 비교
Comparison of Cognitive Control Deficits in Patients with Schizophrenia and Their Unaffected First-Degree Relatives
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives This study aimed to identify the differences in the profiles of cognitive control deficits among schizophrenic patients and endophenotypes. Methods The study examined three groups: remitted patients with schizophrenia (n=54), unaffected first-degree relatives of the probands with schizophrenia (n=36), and a healthy control group (n=51), which were all matched for age, sex, and years of education. The AX version of the continuous performance test was used to examine cognitive control. The error rate, correct response times of each subset (AX, BX, AY, BY), and d’ as an indication of the accuracy sensitivity index were calculated. The psychopathology, intelligence, and psychomotor speed were also assessed. Results Patients with schizophrenia showed significantly poorer error rates and d’ in the AX and BX subsets than the others. They showed more delayed correct response times than the healthy control group in all subsets. The first-degree relatives also showed more delayed correct response times in the BX and AY subsets than the healthy control group, but were similar to the patients. Conclusion These findings suggest that cognitive control is impaired in schizophrenia and endophynotypes possibly share this delayed information processing from the higher loading states of cognitive control.
Abstract
Objectives This study aimed to identify the differences in the profiles of cognitive control deficits among schizophrenic patients and endophenotypes. Methods The study examined three groups: remitted patients with schizophrenia (n=54), unaffected first-degree relatives of the probands with schizophrenia (n=36), and a healthy control group (n=51), which were all matched for age, sex, and years of education. The AX version of the continuous performance test was used to examine cognitive control. The error rate, correct response times of each subset (AX, BX, AY, BY), and d’ as an indication of the accuracy sensitivity index were calculated. The psychopathology, intelligence, and psychomotor speed were also assessed. Results Patients with schizophrenia showed significantly poorer error rates and d’ in the AX and BX subsets than the others. They showed more delayed correct response times than the healthy control group in all subsets. The first-degree relatives also showed more delayed correct response times in the BX and AY subsets than the healthy control group, but were similar to the patients. Conclusion These findings suggest that cognitive control is impaired in schizophrenia and endophynotypes possibly share this delayed information processing from the higher loading states of cognitive control.
참고문헌 (31)
- Green MF, "Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS", Schizophr Res, 72, pp.41~51 (2004)
- Egan MF, "Relative risk for cognitive impairments in siblings of patients with schizophrenia", Biol Psychiatry, 50, pp.98~107 (2001)
- Cannon TD, "Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers", Arch Gen Psychiatry, 51, pp.651~661 (1994)
- 김도훈, "조현병 환자와 발병하지 않은 일차친족에서 신경인지의 결함", 생물정신의학, 21(2), pp.65~73 (2014), 대한생물정신의학회
- Miller EK, "The prefrontal cortex and cognitive control", Nat Rev Neurosci, 1, pp.59~65 (2000)
- Buschman TJ, "Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices", Science, 315, pp.1860~1862 (2007)
- Cohen JD, "A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges", Philos Trans R Soc Lond B Biol Sci, 351, pp.1515~1527 (1996)
- Cohen JD, "Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks", J Abnorm Psychol, 108, pp.120~133 (1999)
- Minzenberg MJ, "Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia", Arch Gen Psychiatry, 66, pp.811~822 (2009)
- Richard AE, "Persistence, diagnostic specificity and genetic liability for context-processing deficits in schizophrenia", Schizophr Res, 147, pp.75~80 (2013)
- Rotaru DC, "The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia", Rev Neurosci, 23, pp.97~109 (2012)
- MacDonald AW 3rd, "A specific deficit in context processing in the unaffected siblings of patients with schizophrenia", Arch Gen Psychiatry, 60, pp.57~65 (2003)
- Docherty NM, "Immediate memory, attention and communication disturbances in schizophrenia patients and their relatives", Psychol Med, 29, pp.189~197 (1999)
- Chkonia E, "First-order relatives of schizophrenic patients are not impaired in the Continuous Performance Test", J Clin Exp Neuropsychol, 32, pp.481~486 (2010)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders" (1994), American Psychiatric Association
- Leucht S, "Clinical implications of Brief Psychiatric Rating Scale scores", Br J Psychiatry, 187, pp.366~371 (2005)
- 안용민, "한글판 Montgomery-Åsberg 우울증 평가 척도의 표준화 연구", 신경정신의학, 44(4), pp.466~476 (2005), 대한신경정신의학회
- Hahn OS, "Development of Korean version of Structured Clinical Interview Schedule for DSM-IV Axis I Disorder: interrater reliability", J Korean Neuropsychiatr Assoc, 39, pp.362~372 (2000)
- Lee YS, "Validity of short forms of the Korean-Wechsler Adult Intelligence Scale", Korean J Clin Psychol, 14, pp.111~116 (1995)
- Morrison MW, "Reliability of the Finger Tapping Test and a note on sex differences", Percept Mot Skills, 48, pp.139~142 (1979)
- Servan-Schreiber D, "Schizophrenic deficits in the processing of context. A test of a theoretical model", Arch Gen Psychiatry, 53, pp.1105~1112 (1996)
- Braver TS, "A theory of cognitive control, aging cognition, and neuromodulation", Neurosci Biobehav Rev, 26, pp.809~817 (2002)
- Ophir E, "Cognitive control in media multitaskers", Proc Natl Acad Sci U S A, 106, pp.15583~15587 (2009)
- Cohen RM, "Dysfunction in a prefrontal substrate of sustained attention in schizophrenia", Life Sci, 40, pp.2031~2039 (1987)
- Barch DM, "Dissociating working memory from task difficulty in human prefrontal cortex", Neuropsychologia, 35, pp.1373~1380 (1997)
- Wang Q, "Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: a study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls", Schizophr Res, 89, pp.293~298 (2007)
- Martínez-Arán A, "Cognitive dysfunctions in bipolar disorder: evidence of neuropsychological disturbances", Psychother Psychosom, 69, pp.2~18 (2000)
- Sitskoorn MM, "Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis", Schizophr Res, 71, pp.285~295 (2004)
- Snitz BE, "Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes", Schizophr Bull, 32, pp.179~194 (2006)
- 김도훈, "Shared and Distinct Neurocognitive Endophenotypes of Schizophrenia and Psychotic Bipolar Disorder", Clinical Psychopharmacology and Neuroscience, 13(1), pp.94~102 (2015), 대한정신약물학회
- Barker MJ, "Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis", Arch Clin Neuropsychol, 19, pp.437~454 (2004)
