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논문KCI 등재

조현병 환자에서 정신병리와 인지 기능과의 연관성

Relationship between Psychopathology and Cognitive Function in Patients with Schizophrenia

김연수|오민경|정도운|강제욱|문정준|심주철|공보금|김임규|임지섭|김성진
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2013.10|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제19권 제2호|pp. 108-118

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참고문헌

키워드

Cognition조현병인지기능SchizophreniaPsychopathology임상증상PANSS
주제분류정신과학

초록

Objectives：Cognitive dysfunction is one of the major symptoms of schizophrenia, and has a diverse effect on the prognosis and course of schizophrenia. Several studies have been done about the correlation between cognitive dysfunction and clinical symptoms of schizophrenia, but the results of those studies were not clear. This study was performed to confirm the correlation between cognitive dysfunction and clinical symptoms of schizophrenia. Methods：We studied 117 patients with schizophrenia. We assessed clinical symptoms and the cognitive function of the patients, and analyzed the statistical correlation between clinical symptoms and the cognitive function. For clinical symptoms, Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression-Severity(CGI-S) and Hamilton Depression Rating Scale(HDRS) were performed. For cognitive function, Digit Span Test, Visual Span Test, Stroop Color Word Test(SCWT), Continuous Performance Test(CPT), Wisconsin Card Sorting Test(WCST), and Digit Symbol Substitution Test(DSST) were performed. Results：There was significant correlation between CPT and clinical symptoms. The WCST revealed that Cate-gories Achieved(CA) have significant correlation with disorganization symptoms among 5-factor model of PANSS (p＜0.05). DSST revealed that the total score(p＜0.01), negative syndrome(p＜0.01), general psychopathology(p＜ 0.01) among 3 kind major area classification of PANSS and disorganization symptoms of 5-factor model of PANSS(p ＜0.001) have significant correlation. Conclusion：This study revealed the correlation between the cognitive function and a part of clinical symptoms in patients with schizophrenia, as shown through the CPT, WCST and DSST.

Abstract

Objectives：Cognitive dysfunction is one of the major symptoms of schizophrenia, and has a diverse effect on the prognosis and course of schizophrenia. Several studies have been done about the correlation between cognitive dysfunction and clinical symptoms of schizophrenia, but the results of those studies were not clear. This study was performed to confirm the correlation between cognitive dysfunction and clinical symptoms of schizophrenia. Methods：We studied 117 patients with schizophrenia. We assessed clinical symptoms and the cognitive function of the patients, and analyzed the statistical correlation between clinical symptoms and the cognitive function. For clinical symptoms, Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression-Severity(CGI-S) and Hamilton Depression Rating Scale(HDRS) were performed. For cognitive function, Digit Span Test, Visual Span Test, Stroop Color Word Test(SCWT), Continuous Performance Test(CPT), Wisconsin Card Sorting Test(WCST), and Digit Symbol Substitution Test(DSST) were performed. Results：There was significant correlation between CPT and clinical symptoms. The WCST revealed that Cate-gories Achieved(CA) have significant correlation with disorganization symptoms among 5-factor model of PANSS (p＜0.05). DSST revealed that the total score(p＜0.01), negative syndrome(p＜0.01), general psychopathology(p＜ 0.01) among 3 kind major area classification of PANSS and disorganization symptoms of 5-factor model of PANSS(p ＜0.001) have significant correlation. Conclusion：This study revealed the correlation between the cognitive function and a part of clinical symptoms in patients with schizophrenia, as shown through the CPT, WCST and DSST.

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