조현병 및 정신증 고위험군에서의 작업기억 손상
Working Memory Deficits in Ultra-High Risk for Psychosis and Schizophrenia
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Objectives : The aim of this study was to investigate whether verbal and spatial working memory functions were impaired not only in patients with schizophrenia but also in people at ultra-high risk for first-episode psychosis. Methods : Twenty-five patients (M 13, F 12) with schizophrenia (SPR), 21 people at ultra-high risk for psychosis (UHR)(M 10, F 11) and 19 normal controls (NC)(M 10, F 9) were recruited. The working memory was assessed by using the verbal and spatial n-back test. The working memory load increased incrementally from the 0-back to the 3-back condition. Results : SPR performed significantly lower than NC and UHR in terms of hit rates of verbal and spatial n-back test. UHR subjects conducted significantly lower than NC and higher in trend-level than SPR in terms of hit rates of verbal and spatial n-back test. These differences were derived from the high working memory load (2-back and 3-back), not from the low working memory load (0-back and 1-back). There was no significant difference between the verbal and spatial n-back test across the three groups. Conclusion : These findings suggest that verbal and spatial working memory dysfunction may be general rather than differential in terms of stimuli modality, and this working memory deficit may be an important trait factor in schizophrenia.
Abstract
Objectives : The aim of this study was to investigate whether verbal and spatial working memory functions were impaired not only in patients with schizophrenia but also in people at ultra-high risk for first-episode psychosis. Methods : Twenty-five patients (M 13, F 12) with schizophrenia (SPR), 21 people at ultra-high risk for psychosis (UHR)(M 10, F 11) and 19 normal controls (NC)(M 10, F 9) were recruited. The working memory was assessed by using the verbal and spatial n-back test. The working memory load increased incrementally from the 0-back to the 3-back condition. Results : SPR performed significantly lower than NC and UHR in terms of hit rates of verbal and spatial n-back test. UHR subjects conducted significantly lower than NC and higher in trend-level than SPR in terms of hit rates of verbal and spatial n-back test. These differences were derived from the high working memory load (2-back and 3-back), not from the low working memory load (0-back and 1-back). There was no significant difference between the verbal and spatial n-back test across the three groups. Conclusion : These findings suggest that verbal and spatial working memory dysfunction may be general rather than differential in terms of stimuli modality, and this working memory deficit may be an important trait factor in schizophrenia.
참고문헌 (31)
- Baddeley A., "Working memory", Science, 255, pp.556~559 (1992)
- Baddeley A., "The fractionation of working memory", Proc Natl Acad Sci USA, 93, pp.13468~13472 (1996)
- Baddeley A, "Working memory and executive control", Philos Trans R Soc Lond B Biol Sci, 351, pp.1397~1403 (1996)
- Saykin AJ, "Neuropsychological function in schizophrenia. Selective impair ment in memory and learning", Arch Gen Psychiatry, 48, pp.618~624 (1991)
- Hutton SB, "Executive function in first-episode schizophrenia", Psychol Med, 28, pp.463~473 (1998)
- Heinrichs RW, "Neurocognitive deficit in schizophrenia: a quantitative review of the evidence", Neuropsychology, 12, pp.426~445 (1998)
- Wood SJ, "Spatial working memory ability is a marker of risk-for-psychosis", Psychol Med, 33, pp.1239~1247 (2003)
- Smith CW, "Spatial working memory deficits in adolescents at clinical high risk for schizophrenia", Schizophr Res, 81, pp.211~215 (2006)
- Seidman LJ, "Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies", Schizophr Bull, 32, pp.507~524 (2006)
- Yung AR, "The prodromal phase of first-episode psychosis: past and current conceptualizations", Schizophr Bull, 22, pp.353~370 (1996)
- Yung AR, "Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group", Schizophr Res, 60, pp.21~32 (2003)
- Miller TJ, "Prospective diagnosis of the initial prodrome for schizoph-renia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity", Am J Psychiatry, 159, pp.863~865 (2002)
- Wagner M, "Ruhr-mann S, et al. Cognitive and neurobiological risk indicators in early and late prodromal stages", Schizophr Res, 86, pp.35~36 (2006)
- Callicott JH, "Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia", Neuropsychopharmacology, 18, pp.186~196 (1998)
- Carter CS, "Functional hypofrontality and working memory dysfunction in schi-zophrenia", Am J Psychiatry, 155, pp.1285~1287 (1998)
- Green A, "Muscarinic and nicotinic receptor modulation of object and spatial n-back working memory in humans", Pharmacol Biochem Behav, 81, pp.575~584 (2005)
- Sandra S Kindermann, "Spatial working memory among middle-aged and older patients with schizophrenia and volunteers using fMRI", Schizophrenia Research 1 June, 68, pp.203~216 (2004)
- Silver H, "Verbal as well as spatial working memory pre-dicts visuospatial processing in male schizophrenia patients", Schi-zophr Res, 101, pp.210~217 (2008)
- Stephane M, "The dynamic architecture of working me-mory in schizophrenia", Schizophr Res, 92, pp.160~167 (2007)
- White T, "Verbal and visuospatial working memory development and deficits in children and adolescents with schizophrenia", Early Interv Psychiatry, 4, pp.305~313 (2010)
- P). 2nd ed, "Structured Clinical Interview for DSM-IV Axis I Disorders: Patient Edition (SCID-I", pp.1996, First MB
- McGlashan TH, "Structured Interview for Prodromal Syndromes (SIPS). 4th ed" (2003), Yale University
- PS). 2nd ed, "Structured Clinical Interview for DSM-IV Axis I Disorders: Non-Patients Edition (SCID-I", pp.1996, First MB
- Andreasen NC, "Correlational studies of the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms: an overview and update", Psychopathology, 28, pp.7~17 (1995)
- Becker HE, "Neurocognitive functioning before and after the first psychotic episode: does psychosis result in cognitive deterioration?", Psychol Med, 40, pp.1599~1606 (2010)
- Kim KR, "Neurocognitive performance in subjects at ultrahigh risk for schizophrenia: a comparison with first-episode schizophrenia", Compr Psychiatry, 52, pp.33~40 (2011)
- Bruder GE, "Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations", Biol Psychiatry, 58, pp.901~907 (2005)
- Saperstein AM, "Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunction", Schizophr Bull, 32, pp.498~506 (2006)
- Krieger S, "Cognitive subprocesses and schizophrenia. B. Maze tasks", Acta Psychiatr Scand Suppl, pp.28~41 (2001)
- Badcock JC, "Acts of control in schizophrenia: dissociating the components of inhibition", Psychol Med, 32, pp.287~297 (2002)
- Kroken RA, "Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study", BMC Psychiatry, 9, pp.24~32 (2009)