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논문KCI 등재

주의력결핍 과잉행동장애 아동의 혈중 철의 농도와전두엽 기능과의 관련성

The Relation of Blood Iron Level with Frontal Function in Children with Attention-Deficit/Hyperactivity Disorder

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주제분류정신과학

초록

ObjectivesZZAttention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder showing many neuropsychological deficits. Many environmental risk factors have been thought to increase the risk for the disorder. We examined blood iron levels in children with ADHD and a control group to find an association between iron deficit and diagnosis, neuropsychological characteristics and clinical features. MethodsZZAn ADHD group (n=50) and control group (n=45) of children 6–12 years of age were recruited. Both groups were diagnosed by semi-structured interview, and they were evaluated using the Korean version of the ADHD Rating Scale (K-ARS), Korean version of IOWA Conner’s Rating Scale (K-IOWA), intelligence quotient (IQ), and neurocognitive function tests (continuous performance test, children’s color trails test, Stroop color-word test). Iron levels in blood were determined using the inductively coupled plasma mass spectrometry instrument. Independent t-test and correlation were used to determine the relation of blood iron levels with symptom ratings and neurocognitive function. Logistic regression was performed to determine the diagnostic value of blood iron levels. ResultsZZBlood iron levels were significantly lower in ADHD than in control and showed negative correlation with K-ARS and K-IOWA scores. Blood iron levels showed positive association with IQ and Stroop color-word test results and negative association with results of continuous performance testing. Low blood iron levels predicted the diagnosis of ADHD. ConclusionZZLower levels of blood iron were associated with ADHD symptom severity, IQ, and frontal lobe-mediated neurocognitive function. As blood iron levels may influence ADHD, measurement of iron levels in blood may be useful for evaluation of symptoms and neurocognitive function in ADHD.

Abstract

ObjectivesZZAttention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder showing many neuropsychological deficits. Many environmental risk factors have been thought to increase the risk for the disorder. We examined blood iron levels in children with ADHD and a control group to find an association between iron deficit and diagnosis, neuropsychological characteristics and clinical features. MethodsZZAn ADHD group (n=50) and control group (n=45) of children 6–12 years of age were recruited. Both groups were diagnosed by semi-structured interview, and they were evaluated using the Korean version of the ADHD Rating Scale (K-ARS), Korean version of IOWA Conner’s Rating Scale (K-IOWA), intelligence quotient (IQ), and neurocognitive function tests (continuous performance test, children’s color trails test, Stroop color-word test). Iron levels in blood were determined using the inductively coupled plasma mass spectrometry instrument. Independent t-test and correlation were used to determine the relation of blood iron levels with symptom ratings and neurocognitive function. Logistic regression was performed to determine the diagnostic value of blood iron levels. ResultsZZBlood iron levels were significantly lower in ADHD than in control and showed negative correlation with K-ARS and K-IOWA scores. Blood iron levels showed positive association with IQ and Stroop color-word test results and negative association with results of continuous performance testing. Low blood iron levels predicted the diagnosis of ADHD. ConclusionZZLower levels of blood iron were associated with ADHD symptom severity, IQ, and frontal lobe-mediated neurocognitive function. As blood iron levels may influence ADHD, measurement of iron levels in blood may be useful for evaluation of symptoms and neurocognitive function in ADHD.

참고문헌 (39)

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Effects of Iron Supplementation on Attention Deficit Hyperactivity Disorder in Children Treated with MethylphenidateElham Bidabadi, Maryam Kousha, Melika Amoukhteh, Mohammad-Javad Khosousi, Parham Mashouf, Sepehr Tohidi, Tamkin Shahraki대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제4호Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity DisorderBilal Ustundag, Ipek Percinel Yazici, Kemal Utku Yazici대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2019 · 제17권 제1호주의력결핍/과잉운동 장애 아동들에서 뇌 단일 광전자 방출 전산화 단층촬영(SPECT)으로 측정된 뇌혈류 이상과 인지적 특성들과의 연관관계문재석, 오은영, 윤석남, 이동수, 이재성, 조선미, 황이삭대한생물치료정신의학회 · 생물치료정신의학2002 · 제8권 제2호주의력결핍 과잉행동장애 아동의 언어기억능력에 영향을 미치는 신경인지기능차영, 서완석, 정진영, 천은진대한생물치료정신의학회 · 생물치료정신의학2013 · 제19권 제1호신경인지기능 손상 유무에 따른 아동기 ADHD의 증상 특성김지연, 김희진, 배대석, 서완석, 이상일한국정서행동장애학회 · 정서·행동장애연구2019 · 제35권 제3호주의력결핍 과잉행동장애 아동과 정상 아동의 지능, 기억 및 전두엽 관리 기능에 대한 비교 연구김희철, 류설영, 정철호대한생물치료정신의학회 · 생물치료정신의학2007 · 제13권 제2호

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