Measuring T1 contrast in ex-vivo prostate tissue at the Earth’s magnetic field
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A former study has shown that the spin-lattice relaxation time (T1) in cancerous prostate tissue had enhanced contrast at an ultra-low magnetic field, 132 uT. To study the field dependence and the origin of the contrast we measured T1 in pairs of ex-vivo prostate tissues at the Earth’s magnetic field. A portable and coil-based nuclear magnetic resonance (NMR) system was adopted for T1 measurements at 40 uT. The T1 contrast, delta = 1 - T1 (more cancer)/T1(less cancer), was calculated from each pair. Additionally, we performed pathological examinations such as Gleason’s score, cell proliferation index, and micro-vessel density (MVD), to quantify correlations between the pathological parameters and T1 of the cancerous prostate tissues.
Abstract
A former study has shown that the spin-lattice relaxation time (T1) in cancerous prostate tissue had enhanced contrast at an ultra-low magnetic field, 132 uT. To study the field dependence and the origin of the contrast we measured T1 in pairs of ex-vivo prostate tissues at the Earth’s magnetic field. A portable and coil-based nuclear magnetic resonance (NMR) system was adopted for T1 measurements at 40 uT. The T1 contrast, delta = 1 - T1 (more cancer)/T1(less cancer), was calculated from each pair. Additionally, we performed pathological examinations such as Gleason’s score, cell proliferation index, and micro-vessel density (MVD), to quantify correlations between the pathological parameters and T1 of the cancerous prostate tissues.
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