T2-relaxation Time Measurement of ex vivo 1H MR Metabolite Peaks for Evaluation of Human Stomach Cancer
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초록
In this study, transverse relaxation time (T2) measurement and the evaluation of the characteristics of the spectral peak related to stomach tissue metabolites were performed using ex vivo proton magnetic resonance spectroscopic imaging (MRSI) at 1.5-T MRI/S instruments. Thirty-two gastric tissues resected from 12 patients during gastric cancer surgery, of which 19 were normal tissue and 13 were cancerous tissue, were used to measure the T2 of the magnetic resonance spectroscopy (MRS) peaks. The volume of interest data results from the MRSI measurements were extracted from the proper muscle (MUS) layer and the composite mucosa/submucosa (MC/SMC) layer and were statistically analyzed. MR spectra were acquired using the chemical shift imaging (CSI) point resolved spectroscopy (CSI-PRESS) technique with the parameters of pulse repetition time (TR) and echo times (TE) TR/(TE1,TE2)=1500 msec/(35 msec, 144 msec), matrix size=24×24, NA=1, and voxel size=2.2×2.2×4 mm3. In conclusion, the measured T2 of the metabolite peaks, such as choline (3.21ppm) and lipid (1.33ppm), were significantly decreased (p<0.01 and p<0.05, respectively) in the cancerous stomach tissue.
Abstract
In this study, transverse relaxation time (T2) measurement and the evaluation of the characteristics of the spectral peak related to stomach tissue metabolites were performed using ex vivo proton magnetic resonance spectroscopic imaging (MRSI) at 1.5-T MRI/S instruments. Thirty-two gastric tissues resected from 12 patients during gastric cancer surgery, of which 19 were normal tissue and 13 were cancerous tissue, were used to measure the T2 of the magnetic resonance spectroscopy (MRS) peaks. The volume of interest data results from the MRSI measurements were extracted from the proper muscle (MUS) layer and the composite mucosa/submucosa (MC/SMC) layer and were statistically analyzed. MR spectra were acquired using the chemical shift imaging (CSI) point resolved spectroscopy (CSI-PRESS) technique with the parameters of pulse repetition time (TR) and echo times (TE) TR/(TE1,TE2)=1500 msec/(35 msec, 144 msec), matrix size=24×24, NA=1, and voxel size=2.2×2.2×4 mm3. In conclusion, the measured T2 of the metabolite peaks, such as choline (3.21ppm) and lipid (1.33ppm), were significantly decreased (p<0.01 and p<0.05, respectively) in the cancerous stomach tissue.
참고문헌 (32)
- "Clinical review of gastric cancer in Korea", 26(2), pp.8~70 (1988), Korea Green Cross Co.
- "Epidemiologic features and perspective of stomach cancer in Korea", 26(2), pp.9~64 (1998), Korea Green Cross Co.
- "Chemoprevention of Gastric Cancer", 9(1), pp.1~7 (2004)
- "In vitro MR imaging of the resected stomach with a 4.7-T superconducting magnet", 191, pp.129~134 (1994)
- "Extraserosal invasion in advanced gastric cancer evaluation with MR imaging", 192, pp.87~91 (1994)
- "MRI for staging of gastric carcinoma: first, results of an experimental prospective study", 21, pp.66~72 (1997)
- "Nuclear induction", 69, pp.127~ (1946)
- "Magnetic Resonance Ima- ging", pp.331~347 (1999)
- "About MRI Physics" (1997), UMSM
- "Magnetic Resonance Imaging 2nd : Physical and Biological Principles" (1996), Mosby
- "Updated Magnetic Resonance Ima- ging" (1998), Yeomungak
- "Magnetic Resonance Spectroscopy in Biology and Medicine" (1992), Pergamon Press
- "Quantitative localized 1H-MR spectroscopy for clinical use", 31, pp.155~195 (1997)
- "Magnetic resonance imaging of lumen wall using quadrature-typed inside-out receiver coil", 10, pp.886~ (2001)
- "The deve- lopment of signal processing software for single-and multi-voxel MR spectroscopy (Korean)", 39, pp.69~79 (2002)
- "The development of signal-processing system based on PC for MR spectroscopy", pp.32~38 (2002), Inje Univ.
- "Quadrature-typed RF Coil for In vitro Magnetic Resonance Imaging", Spectroscopy, 2003, 100~
- "Ex vivo MR spectroscopy (1H-MRS) for evaluation of human gastric carci- noma", 22, pp.861~870 (2004)
- "T2-relaxation time measurement of metabo- lite peak in gastric tissue using ex vivo proton magnetic reso- nance spectroscopic imaging", 13, pp.2494~ (2005)
- "The effect of sample freezing on proton magic-angle spinning NMR spectra of biological tissue", 40, pp.166~169 (1998)
- "High-reso- lution magic angle spinning 1H NMR spectroscopy of intact liver and kidney: optimization of simple preparation procedures and biomedical stability of tissue during spectral acquisition", 282, pp.16~23 (2000)
- "High-resolution magic angle spin- ning MRS of breast cancer tissue", 15, pp.327~337 (2002)
- "1H NMR spectroscopy of colon tumors and normal mucosal biopsies; elevated taurine levels and reduced polyethleneglycol absorption in tumors may have diagnostic significance", 6, pp.111~118 (1993)
- "Prostate: benign prostatic hyperplasia, normal periphe- ral zone and adenocarcinoma", 29, pp.285~291 (1993)
- "Human cancers detected by proton MRS and chemical shift imaging ex vivo", 16, pp.1521~1532 (1996)
- "Localized in vivo 1H nuclear MR spectroscopy for evaluation of human uterine cervical carcinoma", 170, pp.1279~1282 (1998)
- "Proton MR and human cervical neoplasia: ex vivo spectroscopy allows distinction of invasive carcinoma of the cervix from carcinoma in situ and other preinvasive lesions", 188, pp.791~796 (1993)
- "Cell-surface carbohydrates and their interactions. I. NMR of N-acetyl neuraminic acid", 399, pp.124~130 (1975)
- "Single-voxel very-short echo-time proton spectroscopy of human brain with B1-intensitive water suppression", 44, pp.964~967 (2000)
- "Quantification of cerebral metabolites in glioma patients with proton MR spec- troscopy using T2 relaxation time correction", 20, pp.343~349 (2002)
- "Quantitative metabolite patterns of human brain tumors: Detection by 1H NMR spectroscopy in vivo and in vitro", 18, pp.705~713 (1994)
- "Loca- lized proton spectroscopy of focal brain pathology in humans: Significant effects of edema on spin-spin relaxation time", 31, pp.537~540 (1994)