聰明湯과 巴戟天聰明湯 열수추출물, 초미세분말제형이 microglia 및 기억력 감퇴 병태모델에 미치는 영향
Effects of ChongMyung-Tang and ChongMyung-Tang added Moutan Cortex Hot water extract & Ultra-fine Powder on Microglia and Memory Deficit Model
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Abstract
This experiment was designed to investigate the effect of the CMT and PCMT hot water extract & ultra-fine powder on microglia and memory deficit model. The effects of the CMT and PCMT hot water extract on expression of IL-1β, IL-6, TNF-α, NOS-Ⅱ, COX-2, IL-10, TGF-β1 mRNA and production of IL-1β, IL-6, TNF-α, NO, ROS in BV2 microglial cell line treated by lipopolysacchaide(LPS) ; serum glucose, uric acid, AChE activity of the memory deficit mice induced by scopolamine ; behavior of the memory deficit mice induced by scopolamine and were investigated, respectively. The CMT and PCMT hot water extract suppressed the expression of IL-1β, IL-6, TNF-α, NOS-Ⅱ, COX-2 mRNA, production of IL-1β, IL-6, TNF-α, NO, ROS and increased the expression of IL-10, TGF-β1 mRNA in BV2 microglial cell line treated by LPS. The PCMT hot water extract & ultra-fine powder increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. The CMT and PCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. According to the above result, it is suggested that the CMT and PCMT hot water extract & ultra-fine powder might be usefully applied for prevention and treatment of dementia.
참고문헌 (29)
- 민성길, "최신정신의학" (2003), 서울 일조각
- Bierer, L.M.,, "Neurochemical correlates of dementia severity in Alzheimer's disease relative importance of the cholinergic deficits Journal of Neurochemistry", ka(f), pp.749~760 (1995)
- 조추용, "치매 예방과 케어", pp.~49 (2002)
- Cacquevel, M.,, "Cytokines in neuroinflammation and Alzheimer's disease", pp.529~534 (2004)
- Kuhl, D.E.,, "In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease", mi(shima), pp.691~699 (1999)
- Mhatre, M.,, "Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis Journal of Alzheimers disease", pp.147~157 (2004)
- 대한한방신경정신과학회, "한방신경정신과학", 문당, pp.311~320 (2005)
- 최병만 외, "木槿皮가 CT-105로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響", pp.119~140 (2004)
- 김명진 외, "木瓜가 CT-105로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響", pp.97~118 (2005)
- 박지운 외, "聰明湯과 木槿皮聰明湯이 CT105와 βA로 유도된 Alzheimer's Disease病態 모델에 미치는 영향" (2004), 대전대학교대학원
- 하수영 외, "聰明湯과 山査聰明湯이 Alzheimer's Disease 病態 모델에 미치는 影響" (2004), 대전대학교대학원
- 김현수 외, "巴戟天이 痴病態모델에 미치는 영향", pp.45~58 (2003)
- 최현정, "한약제형 선호도에 관한 설문조사", pp.356~367 (2004)
- Song, L.L.,, "Study on pharmacology of ultra-fine particles compound Rehmannia", pp.436~439 (2002)
- Skehan, "New colorimetric cytotoxicity assay for anticancer drug screening Journal of the National Cancer Institute", pp.1107~1112 (1990)
- Hunot, S.,, "FcepsilonRII", CD23 is expressed in Parkinson's disease and induces production of nitric oxide and tumor necrosis factor-alpha in glial cells The Journal of Neuroscience, 1999, pp.hu(t), 3440~3447
- Trabace, L.,, "Biochemical and neurobehavioral profile of CHF2819 orally active acetylcholinesterase inhibitor for Alzheimer's disease The Journal of Pharmacology and Experimental Therapeutics" (2000)
- Kasa, P.,, "Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptiveenzyme-positive structures in the human and rat brain", pp.89~100 (2000)
- Geerts, H, "Indicators of neuroprotection with galantamine", pp.519~524 (2005)
- Spassov, A.,, "Study of ancholinesterase drugs galanthamine and donepezil on scopolamine-induced amnesia in rats" (2004)
- Xu, Y.H.,, "Review and analysis of present status of the micronization of Chinese traditional medicine", pp.497~500 (2004)
- Woo, M.S.,, "Selective modulation of lipopolysaccharide- stimulated cytokine expression and mitogen-activated protein kinase pathways by dibutyryl-cAMP in BV2 microglial cells", pp.1 86~2 96 (2003)
- Marcheselli, V.L.,, "Sustained induction of prostaglandin endoperoxide-2 by seizure in hippocampus The Journal of biological chemistry", pp.24794~24799 (1997)
- Pasinatti, G.M.,, "Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain", pp.319~324 (1998)
- Yen, G.C.,, "Nitric oxide-scavenging and antioxidant effects of Uraria crinita root", pp.471~478 (2001)
- Mates, J.M, "Antioxidant enzymes and human disease" (1999)
- Messier, C, "The absence of effect of glucose on memory is associated with low susceptibility to the amnestic effects of scopolamine in a strain of mice", pp.1 47~2 57 (1998)
- Degrell, I.,, "Purine metabolites in the CSF in presenile and senile dementia of Alzheimer type and in multi infarct dementia Archives of Gerontology and Geriatrics", pp.173~178 (1998)
- Degrell, I.,, "Purine metabolites in the CSF in presenile and senile dementia of Alzheimer type and in multi infarct dementia Archives of Gerontology and Geriatrics", pp.173~178 (1998)