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木瓜가 CT105와 βA로 誘導된Alzheimer's Disease病態 모델에 미치는 影響

The Effects of Chaenomelis fructus,(CMF) Extract on the Alzheimer's Disease Model Induced by CT-105 and βA

정인철|이상룡|김명진
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2005.06|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제16권 제1호|pp. 97-117

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참고문헌

주제분류한의학

초록

Abstract

This research investigates the effect of the Chaenomelis fructus(CMF) on Alzheimer's disease. Specifically, the effects of the CMF extract on (1) IL-1β, IL-6, and TNF-α mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA of PC-12 cells treated with CT-105; (3) the AChE activity and the APP production of PC-12 cell treated with CT-105; (4) the behavior of AD mice with βA; (5) expression of IL-1β, TNF-α, MDA, IL-1β mRNA, TNF-α mRNA, and ROS; (6) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with βA were investigated. The results were summarized as follows ; 1. The CMF extract suppressed the expression of IL-1β, IL-6 and TNF-α mRNA in THP-1 cells treated with LPS. 2. The CMF extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The CMF extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. A significant inhibitory effect on the memory deficit was shown on the CMF extract group of the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The CMF extract suppressed the over-expression of IL-1β protein, TNF-α protein, MDA, IL-1β mRNA, TNF-α mRNA, CD68/GFAP, and ROS in the mice with Alzheimer's disease induced by βA. 6. The CMF extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA. These results suggest that the CMF extract may be effective for the treatment of Alzheimer's disease. Investigation into the clinical use of the CMF extract for Alzheimer's diseaseis suggested for future research.

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관련 논문AI추천

장원단이 CT105와 βA로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響김건진, 정대규대한한방신경정신과학회 · 동의신경정신과학회지2006 · 제17권 제2호목근피가 CT105와 Ba로 유도된 Alzheimer's Disease 병태모델에 미치는 영향이상룡, 정인철, 최병만대한한방신경정신과학회 · 동의신경정신과학회지2004 · 제15권 제2호聰明湯과 木槿皮聰明湯이 CT105와 βA로 유도된 Alzheimer's Disease 病態 모델에 미치는 영향박지운, 이상룡, 정인철대한한방신경정신과학회 · 동의신경정신과학회지2006 · 제17권 제1호공진단이 CT105로 유도된 Alzheimer's disease 병태모델에 미치는 영향정대규, 황선미대한한방신경정신과학회 · 동의신경정신과학회지2004 · 제15권 제2호녹용대보탕이 β-Amyloid로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響서규태, 이은경, 정대규, 최철홍대한한방신경정신과학회 · 동의신경정신과학회지2007 · 제18권 제2호山査肉이 Alzheimer's Disease 病態 모델에 미치는 영향이상룡, 정인철한의병리학회 · 동의생리병리학회지2002 · 제16권 제2호

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