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한국 성인 남성에서 안정 시 심박수, QTc 간격 및 혈액검사 지표와 대사증후군 위험요인과의 관계

Resting Heart Rate, QTc Interval, and Laboratory Variables in Relation to Risk Factors of Metabolic Syndrome in Korean Adult Male

김철규|차선경
한국보건정보통계학회 (The Korean Society of Health informatics statistics)|2017.11|보건정보통계학회지 (Journal of Health Informatics and Statistics)|제42권 제4호|pp. 322-329|DOI https://doi.org/10.21032/jhis.2017.42.4.322

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키워드

Heart rateMetabolic syndromeMaleBlood cell countsBlood chemical analyses

초록

Objectives: Each of resting heart rate, QTc interval, blood uric acid, leukocyte count, erythrocyte count, and calcium and other laboratory variables were reported to be related to metabolic syndrome. Thus, more variables including the above are extensively examined together to verify the effect on metabolic syndrome in Korean adult male. Methods: A total of 889 male subjects who have undergone healthy volunteer screening from June 2011 to January 2016 for phase 1 clinical trial were analyzed. The criteria for metabolic syndrome included blood pressure, fasting plasma glucose, triglyceride, highdensity lipoprotein (HDL) by American Heart Association/National Heart Lung and Blood Institute (AHA/NHLBI, 2005), and body mass index (BMI) by American Association of Clinical Endocrinologists (AACE, 2003). Heart rate, QTc interval, complete blood cell count, serum creatinine, uric acid, calcium, AST, ALT, and alkaline phosphatase were included as risk factors for metabolic syndrome. The data were analyzed by t-test, ANOVA, Pearson correlation coefficient, and multiple linear regression analysis using SAS 9.4. Results: About 4.4% of subjects had at least 3 of 5 criteria for metabolic syndrome. Age, leukocyte count, erythrocyte count, AST, ALT, uric acid, and calcium were positive correlated (p<0.05) with the count of satisfied metabolic syndrome criteria among age, resting heart rate, QTc interval, laboratory variables. Six variables-Age, erythrocyte count, uric acid, ALT, calcium, and leukocyte-were selected as significant variables for explaining the count of satisfied criteria for metabolic syndrome by multiple regression analysis, of which the coefficient of determination was 11%. Conclusions: The count of satisfied criteria for metabolic syndrome increased as the age becomes older, which signifies the importance of management in the old age. Other variables such as erythrocyte, uric acid, ALT, calcium, leukocyte should be managed or monitored more carefully to reduce metabolic syndrome.

Abstract

Objectives: Each of resting heart rate, QTc interval, blood uric acid, leukocyte count, erythrocyte count, and calcium and other laboratory variables were reported to be related to metabolic syndrome. Thus, more variables including the above are extensively examined together to verify the effect on metabolic syndrome in Korean adult male. Methods: A total of 889 male subjects who have undergone healthy volunteer screening from June 2011 to January 2016 for phase 1 clinical trial were analyzed. The criteria for metabolic syndrome included blood pressure, fasting plasma glucose, triglyceride, highdensity lipoprotein (HDL) by American Heart Association/National Heart Lung and Blood Institute (AHA/NHLBI, 2005), and body mass index (BMI) by American Association of Clinical Endocrinologists (AACE, 2003). Heart rate, QTc interval, complete blood cell count, serum creatinine, uric acid, calcium, AST, ALT, and alkaline phosphatase were included as risk factors for metabolic syndrome. The data were analyzed by t-test, ANOVA, Pearson correlation coefficient, and multiple linear regression analysis using SAS 9.4. Results: About 4.4% of subjects had at least 3 of 5 criteria for metabolic syndrome. Age, leukocyte count, erythrocyte count, AST, ALT, uric acid, and calcium were positive correlated (p<0.05) with the count of satisfied metabolic syndrome criteria among age, resting heart rate, QTc interval, laboratory variables. Six variables-Age, erythrocyte count, uric acid, ALT, calcium, and leukocyte-were selected as significant variables for explaining the count of satisfied criteria for metabolic syndrome by multiple regression analysis, of which the coefficient of determination was 11%. Conclusions: The count of satisfied criteria for metabolic syndrome increased as the age becomes older, which signifies the importance of management in the old age. Other variables such as erythrocyte, uric acid, ALT, calcium, leukocyte should be managed or monitored more carefully to reduce metabolic syndrome.

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대사증후군과 QTc 간격 연장과의 관계박광식, 서민석, 심재용, 이정현, 이혜리, 조완제대한가정의학회 · Korean Journal of Family Medicine2010 · 제31권 제4호심장대사 위험인자와 심박수 변이 성분들 간의 상관관계정호근, 정휘수한국보건정보통계학회 · 보건정보통계학회지2017 · 제42권 제4호한국인의 관상동맥 석회화 수치와 대사증후군, 고감도 C-반응성 단백과의 관련성강현정, 곽종길, 김미현, 문운현, 문일봉(사)한국방사선산업학회 · 방사선산업학회지2020 · 제14권 제1호성인 남성의 안정시 심박수와 비만 지표 및 동맥경직도 간의 연관성강설중, 고광준대한운동학회 · 아시아 운동학 학술지2016 · 제18권 제4호대사증후군 집단의 심박동수 변이의 특징김원, 강동묵, 김정연, 김정일, 여도환, 우종민, 임성견, 조정진대한생물정신의학회 · 생물정신의학2008 · 제15권 제3호대사증후군 유병률과 대사증후군 관련 혈액검사 -일개 대학병원 건강증진센터 수진자 대상으로-박미경, 박정숙대한임상건강증진학회 · Korean Journal of Health Promotion2009 · 제9권 제3호

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