대사증후군 집단의 심박동수 변이의 특징
Characteristics of Heart Rate Variability among Adults with Metabolic Syndrome
1
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Objectives: The authors tried to investigate the characteristics of Heart Rate Variability(HRV) among the subjects with metabolic syndrome for testing the possibility of clinical application of HRV in evaluating metabolic syndrome. Methods: We examined the difference of the means of HRV between 122 subjects of metabolic syndrome and 1057 healthy controls using T-test, and the change of means in HRV according to increasing risk factors of metabolic syndrome. Using multiple regression analysis, we examined the association of HRV with the risk factors of metabolic syndrome. Results: The HRV indices including SDNN (Standard Deviation of all normal NN intervals), RMSSD (the square Root of the Mean Squared Differences of successive all normal NN interval), TP (Total Power), LF (Low Frequency), and HF (High Frequency) was significantly lower in metabolic syndrome group than in normal control group, and the means of all HRV indices except LF/HF were decreased consistently according to increasing risk factors of metabolic syndrome. The fasting glucose, triglyceride, and waist circumference were dependent factors that contributed significantly to the change of HRV. Conclusions: These findings suggest metabolic syndrome adversely affects cardiac autonomic system and HRV could be useful method for evaluating metabolic syndrome.
Abstract
Objectives: The authors tried to investigate the characteristics of Heart Rate Variability(HRV) among the subjects with metabolic syndrome for testing the possibility of clinical application of HRV in evaluating metabolic syndrome. Methods: We examined the difference of the means of HRV between 122 subjects of metabolic syndrome and 1057 healthy controls using T-test, and the change of means in HRV according to increasing risk factors of metabolic syndrome. Using multiple regression analysis, we examined the association of HRV with the risk factors of metabolic syndrome. Results: The HRV indices including SDNN (Standard Deviation of all normal NN intervals), RMSSD (the square Root of the Mean Squared Differences of successive all normal NN interval), TP (Total Power), LF (Low Frequency), and HF (High Frequency) was significantly lower in metabolic syndrome group than in normal control group, and the means of all HRV indices except LF/HF were decreased consistently according to increasing risk factors of metabolic syndrome. The fasting glucose, triglyceride, and waist circumference were dependent factors that contributed significantly to the change of HRV. Conclusions: These findings suggest metabolic syndrome adversely affects cardiac autonomic system and HRV could be useful method for evaluating metabolic syndrome.
참고문헌 (41)
- Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP), "Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults", JAMA, 285, pp.2486~2497 (2001)
- Isomma B AP., "Cardiovascular morbidity and mortality associated with the metabolic syndrome", Diabetes Care, 24, pp.683~689 (2001)
- Lakka H., "The metabolic syndrome and total cardiovascular disease mortality in middle-aged men", JAVA, 288, pp.2709~2716 (2002)
- Isomaa B., "A major health hazard: The metabolic syndrome", Life sciences, 3, pp.2395~2411 (2003)
- Das UN., "Is metabolic syndrome X an inflammatory condition?", Experimental Biological Biological Medicine, 227, pp.989~997 (2002)
- Bray GA., "Obesity and the metabolic Syndrome: Implications for dietetics practitioners", Journal of American Dietetic Association, 104, pp.86~89 (2004)
- Groop L., "Ortho-Melander M. The dysmetabolic syndrome", Journal of Internal Medicine, 250, pp.105~120 (2001)
- Woo JM., "The concept and clinical application for the measurement of heart rate variability", Korean J Psychosomatic Medicine, 12(1), pp.3~14 (2004)
- Promeranz B., "Assessment of autonomic function in humans by heart rate spectral analysis", Am J Physiol, 248, pp.151~153 (1985)
- Hayano J., "Accuracy of assessment of cardiac parasympathetic tone by heart rate variability in normal subjects", Am J Cardiol, 67, pp.199~204 (1991)
- Kamath MV., "Heart rate variability power spectrogram as a potential noninvasive signature of cardiac regulatory system response, mechanisms, and disorders", Heart Vessels, 3, pp.33~41 (1987)
- Malik M., "Heart rate variability", Clin Cardiol, 13, pp.570~576 (1990)
- Woo JM., "The relation between heart rate variability and pharmacotherapy in patient with panic disorder", J Korean Neuropsychiatr Assoc, 44(3), pp.342~349 (2005)
- Hughes JW., "Depressed mood is related to high-frequency heart rate variability during stressors", Psychosomatic Medicine, 62(6), pp.796~803 (2000)
- Liao D., "Multiple metabolic syndrome is associated with lower heart rate variability", Diabetes Care, 21, pp.2116~2122 (1998)
- Lee YJ, "Heart rate variability in metabolic syndrome", J Korean Acad Fam Med, 23(12), pp.1432~1439 (2002)
- Gottsäter A., "Decreased heart rate variability may predict the progression of carotid atherosclerosis in type 2 diabetes", Clin Auton Res, 16, pp.228~234 (2006)
- Liao D., "Lower Heart rate variability is associated with the development of coronary heart disease in individuals with diabestes", Diabetes, 51, pp.3524~3531 (2002)
- Vaishnav S., "Relation between heart rate variability early after acute myocardial infarction and long-term mortality", Am J Cardiol, 73, pp.653~657 (1994)
- Kleiger RE., "Decreased heart rate variability and it’s association with increased mortality after acute myocardial infarction", Am J Cardiol, 59, pp.256~262 (1987)
- Lombardi F., "Heart rate variability as an index of sympathovagal interaction after acute myocardial infarction", Am J Cardiol, 60, pp.1239~1245 (1987)
- Malik M., "Circadian rhythm of heart rate variability after acute myocardial infarction and its influence on the prognostic value of heart rate variability", Am J Cardiol, 66, pp.1049~1054 (1990)
- Martin GJ., "Heart rate variability and sudden death secondary to coronary artery disease during ambulatory electrocardiographic monitoring", Am J Cardiol, 60, pp.86~89 (1987)
- Task Force of European society of Cardiology and North American Society of Pacing and Electrophysiology, "Heart rate variability; standards of measurement, physiological interpretation, and clinical use", Circulation, 93, pp.1043~1065 (1996)
- Defronzo RA., "nsulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease", Diabetic Care, 14, pp.173~194 (1991)
- Reaven GM, "Hypertension and associated metabolic abnormalities. The role of insulin resistance and the sympathoadrenal system", N Engl J Med, 334, pp.374~381 (1996)
- Gardwell B., "The working environment for local public transport personnel" (1983), Stockholm, The Swedish Work Environmental Fund
- Chang SJ., "Job stress, Heart rate variability and Metabolic syndrome", Korean J Occup, 16(1), pp.70~81 (2003)
- Dishman RK., "Heart rate"
- variability, "trait anxiety, and perceived stress among physically fit men and women", Int J Psychophysiol, 37, pp.121~133 (2000)
- Kageyama T., "Long commuting time, extensive over time, and sympathodominant state assessed in terms of short term heart rate variability among male white collar workers in the Tokyo megalopolis", Industrial Health, 36, pp.209~217 (1998)
- Tsuji H., "Impact of reduced heart rate variability on cardiac events.: The Framingham Heart Study", Circulation, 94, pp.2850~2855 (1996)
- Liao D., "Cardiac autonomic function and incident coronary heart disease: Population-based case-cohort study. The ARIC Study. Atherosclerosis Risk in Communities Study", Am J Epidemiol, 45, pp.696~706 (1997)
- Pfeifer MA., "Quantitative evaluation of cardiac parasympathetic activity in normal and diabetic man", Diabetes, 31, pp.339~345 (1982)
- Malik M., "Heart rate variability", Clin Cardiol, 13, pp.570~576 (1990)
- Lombardi F., "Heart rate variability as an index of sympathovagal interaction after acute myocardial infarction", Am J Cardiol, 60, pp.1239~1245 (1987)
- Liao D., "Association of cardiac autonomic function and the development of hypertension. The ARIC study", Am J Hypertension, 9, pp.1147~1156 (1996)
- Kuch B., "Determinants of Short-Period Heart Rate Variability in the General Population", Cardiology, 95(3), pp.131~139 (2001)
- Sevre K., "Autonomic function in hypertensive and normotensive subjects: the importance of gender", Hypertension, 37, pp.1351~1356 (2001)
- Shamon DC., "Aging modulation of heart rate", Am J Physiol, pp.874~877 (1987)
- Woo JM., "Exploration of the determinants in normotive values of heart rate variability", Proceedings from the 46th annual meeting of Korean Neuropsychiatric Association (2003), Seoul