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대사증후군 유병률과 대사증후군 관련 혈액검사 -일개 대학병원 건강증진센터 수진자 대상으로-

The Prevalence of Metabolic Syndrome and its Related Hematologic Tests -A Study of Patients from one University-Based Physical Examination and Health Promotion Center-

박정숙|박미경
대한임상건강증진학회 (Korean Society For Health Promotion And Disease Prevention)|2009.09|Korean Journal of Health Promotion|제9권 제3호|pp. 213-221

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참고문헌

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대사증후군metabolic syndrome혈액검사종합검진hematologic testshealth screen
주제분류기타자연과학

초록

연구배경 : 우리나라는 생활양식의 서구화, 비만인구의 증가 및 고령화로 인해 대사증후군이 급격히 증가하고 있으며, 이로 인해 혈관질환에 의한 사망률이 증가할 것으로 예상된다. 이에 종합검진 수진자를 대상으로 대사증후군 유병률을 확인하고 대사증후군과 관련 가능성이 있는 혈액검사를 파악하고자 한다. 방 법 : 연구대상은 1997년부터 2007년까지 일개 대학병원의 종합검진 수진자의 검사자료 65,533건이다. 대사증후군 유병률은 AHA/NHLBI(2005) 기준을 사용하였고, 대사증후군과 관련된 혈액검사분석은 대사증후군과 비대사증후군의 정상치와 비정상치를 multiple logistic regression analysis로 비교 분석하였다. 결 과 : 대사증후군 유병률은 전체 18.8%로 남자 21.0%, 여자 15.8%이었다. 연령별 유병률 교차비는 20대를 기준으로 하였을 때 30대에서 2.72배, 40대에서 4.08배, 50대에서 6.46배, 60대에서 7.15배, 70대 이상에서는 5.53배로 유의하게 높았다(p=<0.001). 대사증후군과 비대사증후군 간의 남녀 모두에서 유의한 차이를 보이는 혈액검사는 총콜레스테롤, 당화혈색소, 백혈구수, 적혈구수, ALT, GGT, 크레아티닌, 요산, free T4였고, AST는 남자에서, ALP, CRP는 여자에서만 유의한 차이를 보였다. 결 론 : 본 연구에서 확인한 혈액검사의 대부분이 대사증후군과 비대사증후군에서 유의한 차이를 보였다. 따라서 대사증후군과의 명확한 관련성을 확인하기위해서는 반복연구, 대사증후군 각 구성요소와의 관련성 연구 및 인과관계를 확인할 수 있는 전향적 연구가 요구된다.

Abstract

Background The westernization of lifestyle, the prevalence of obesity, and the aging population are rapidly rising in Korea, leading to the anticipation of an increased death rate from vascular disease. In light of the metabolic syndrome and its effects on vascular disease, this study looked at the prevalence of metabolic syndrome and its related hematologic tests. Methods This study examined a total of 65,533 test results of patients seen at one hospital-based physical examination and health promotion center between 1997 and 2007. The AHA/NHLBI (2005) criterion for the metabolic syndrome was used in calculating the prevalence rate. The hematologic tests related to the metabolic syndrome were measured. The ‘metabolic syndrome’ results and the ‘no metabolic syndrome’ results were compared with the multiple logistic regression analysis. Results By sex, metabolic syndrome was found in 21.0% of males, 15.8% of females, and 18.8% of the total number of patients analyzed. By age, the prevalencerate was 2.72 times greater in the 30s, 4.08 times greater in the 40s, 6.46 times greater in the 50s, 7.15 times greater in the 60s, and 5.53 times greater in the 70s or older when the prevalence rate of the 20s was set to 1 (p=<0.001). The hematologic tests that showed significant differences between patients of the metabolic syndrome and others, were total cholesterol, HbA1c, WBC, RBC, ALT, GGT, creatinine, uric acid, Na, and free T4 in both sexes.AST showed significant differences only in men while ALP and CRP showed a significant difference just in women Conclusions Most of the hematologic tests measured in this study showed significant differences between those who had the metabolic syndrome and those who did not. It would be useful to study the relationships between the metabolic syndrome and each of its components.

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