근로자 건강보호목표수준 제안을 위한 이소프렌의 용량-반응 평가 적용연구
Dose-Response Assessment of Isoprene for Occupational Health Protection Target Level
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives: We investigated the method of application of dose-response assessment of Doemstiv industry to present occupational health protection target level. Methods: Melnick data and NTP data using data, deterministic methods and probabilistic approaches were compared. Results: The value of 1.3 ppm, the reference concentration utilizing the NTP data was suggested for the health protection target level Conclusions: The dose-response assessment based on Isoprene revealed that the most important thing is the toxicity endpoint to suggest the health protection target level by utilizing the dose-response assessment to the domestic workplace
Abstract
Objectives: We investigated the method of application of dose-response assessment of Doemstiv industry to present occupational health protection target level. Methods: Melnick data and NTP data using data, deterministic methods and probabilistic approaches were compared. Results: The value of 1.3 ppm, the reference concentration utilizing the NTP data was suggested for the health protection target level Conclusions: The dose-response assessment based on Isoprene revealed that the most important thing is the toxicity endpoint to suggest the health protection target level by utilizing the dose-response assessment to the domestic workplace
참고문헌 (18)
- 산업화학물질의 위해성 평가 연구, "노동부(산업안전보건공단)", ~ (2010)
- Occupational Safety and Health Administration, "Occupational Exposure to 1,3-Butadiene (Amended Final Rule)", ~ (1996)
- 노동부(산업안전보건공단), "물질안전보건자료(Material Safety Data Sheet), 이소프렌(2- 메틸1,3-부타디엔) Case No. 78-79-5", ~
- US Environmental Protection Agency, "Methods for derivation of inhalation reference concentrations and application of inhalation dosimetry", EPA, 8-90, pp.066F, 1994[DOI]
- US Environmental Protection Agency, "Guidelines for Carcinogen Risk Assessment (EPA", 630, 001F), 2005[DOI]
- Crump KS, "Calculation of benchmark dose from Continuous Data", Risk Analysis, 15(1), pp.79~89 (1995)
- US Environment Protection Agency, "The use of the benchmark dose approach in health risk assessment", ~ (1995)
- US Environmental Protection Agency, "Benchmark dose technical guidance Document (EPA", 630, 001), 2000[DOI]
- "National Toxicology Program", Toxicology and carcinogenesis studies of Isoprene (CAS NO. 78-79-5) IN F344, 1999
- Stelljes ME, "Development of an occupational exposure limit for n-propylbromide using benchmark dose methods", Regulatory Toxicology and Pharmacology, 40, pp.136~150 (2004)
- Risk assessment for occupational exposure to chemicals: A review of current methodology (IUPAC Technical Report), "International Union of Pure and Applied Chemistry", ~ (2001)
- Collins JF, "Development of acute inhalation reference exposure levels (RELs) to protect the public from predictable excursions of airborne toxicants", Journal of Applied Toxicology, 24(2), pp.155~156 (2004)
- Clewell HJ, "Determination of an occupational exposure guideline for manganese using the benchmark method", Risk Analysis, 23(5), pp.1031~1046 (2003)
- Filipsson AF, "The benchmark dose method: Review of available models, and recommendations for application in health risk assessment", Critical Reviews in Toxicology, 33(5), pp.505~542 (2003)
- Barnes DG, "Benchmark dose workshop: Criteria for use of a benchmark dose to estimate a reference dose", Regulatory Toxicology and Pharmacology, 21(2), pp.296~306 (1995)
- Crump KS, "A new method for determining allowable daily intake", Fundamental and Applied Toxicology, 4(5), pp.854~871 (1984)
- Gibsona MC, "Comparison of noncancer risk assessment approaches for use in deriving drinking water criteria", Regulatory Toxicology and Pharmacology, 26(3), pp.243~256 (1997)
- Melnick RL, "Isoprene, an endogenous hydrocarbon and industrial chemical, induces multiple organ neoplasia in rodents after 26 weeks of inhalation exposure", Cancer Research, 54(15), pp.5333~5339 (1994)