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실험실 근무자의 화학물질 노출과 건강 위험

A Review on Chemical Exposure and Related Health Risks in Laboratory Workers

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초록

Researchers who work in science and engineering R&D laboratories are commonly exposed to a wide range of chemical, biological and physical hazards. They also may adopt ergonomically poor postures for long periods of time. These factors may increase the risk of adverse health outcomes in laboratory workers. Recently, there were several fatal accidents in the laboratories in universities and research institutes in Korea. Consequently, the ‘Laboratory Safety Act’was enacted in 2006. However, there are concerns about the health risk associated with chronic exposures to hazards,as the management measures provided in this Act are very limited, focusing primarily on accident prevention and compensation for lab work-related accidents. In this article, the methods for assessing exposure to chemicals in laboratory environments are discussed. Also, epidemiological studies examining the association between laboratory exposure and health effects, including cancer and reproductive toxicity are extensively reviewed. Finally, the possible roles of environmental health professionals in this area are suggested, along with a list of critical research needs for properly assessing laboratory workers’ exposure and risk.

Abstract

Researchers who work in science and engineering R&D laboratories are commonly exposed to a wide range of chemical, biological and physical hazards. They also may adopt ergonomically poor postures for long periods of time. These factors may increase the risk of adverse health outcomes in laboratory workers. Recently, there were several fatal accidents in the laboratories in universities and research institutes in Korea. Consequently, the ‘Laboratory Safety Act’was enacted in 2006. However, there are concerns about the health risk associated with chronic exposures to hazards,as the management measures provided in this Act are very limited, focusing primarily on accident prevention and compensation for lab work-related accidents. In this article, the methods for assessing exposure to chemicals in laboratory environments are discussed. Also, epidemiological studies examining the association between laboratory exposure and health effects, including cancer and reproductive toxicity are extensively reviewed. Finally, the possible roles of environmental health professionals in this area are suggested, along with a list of critical research needs for properly assessing laboratory workers’ exposure and risk.

참고문헌 (63)

  1. "Ministry of Education, Science and Technology", 2008 Research and Development ActivitiesSurvey, ~ (2008)
  2. "Ministry of Education, Science and Technology,Korea", Pilot Study for Building a Laboratory Safetyand Health Center, ~ (2009)
  3. "Occupational Safety and Health Administration(OSHA), 29 CFR 1910.1450 ‘Occupational Exposureto Hazardous Chemicals in Laboratories’", ~ (1910)
  4. "Ministry of Education, Science and Technology", Laboratory Safety Act, ~ (2009)
  5. "Ministry of Education, Science and Technology,Korea", 2006 Surveillance on Laboratory Safety andHealth Status of Universities and R&D Institutes, ~ (2006)
  6. Sharam, J, "Cancerincidence among laboratory workers in biomedicalresearch and routine laboratories in Israel: Part I -The cohort study", American Journal of IndustrialMedicine, 44, pp.600~610 (2003)
  7. Rachet, B, "Cancer risk in laboratory workers: An emphasison biological research", American Journal of IndustrialMedicine, 38, pp.651~665 (2000)
  8. Vecchio, D, "Occupationalrisk in health care and research", AmericanJournal of Industrial Medicine, 43, pp.369~397 (2003)
  9. Apostoli,P, "Proposalof a method for identifying exposure to hazardouschemicals in biomedical laboratories", Clinica ChemicaActa, 256, pp.75~86 (1996)
  10. Julien, R., "Strategy to assess exposures of laboratory personnelto select OSHA-regulated chemicals at MassachusettsInstitute of Technology", pp.25~29 (2001), Chemical Health& Safety
  11. ller, S. K, "Exposures of geotechnical laboratoryworkers to respirable crystalline silica", AppliedOccupational and Environmental Hygiene, 14, pp.39~44 (1999)
  12. Kretchman, K, "Exposure assessment in a laboratoryenvironment" (2002), Chemical Health & Safety
  13. Henn, S. A., "Task- and time-dependentweighting factors in a retrospective exposureassessment of chemical laboratory workers", Journalof Occupational and Environmental Hygiene, 4, pp.71~79 (2007)
  14. Zalk, D. M, "History and evolutionof control banding: A review", Journal of Occupationaland Environmental Health, 5, pp.330~346 (2008)
  15. Hashimoto, H, "Evaluationof the control banding method - Comparison withmeasurement-based comprehensive risk assessment", Journal of Occupational Health, 49, pp.482~492 (2007)
  16. Paik, S. Y, "Applicationof a pilot control banding tool for risk level assessmentand control of nanoparticle exposures", Annalsof Occupational Hygiene, 52, pp.419~428 (2008)
  17. Li, F. P., "Cancer mortality among chemists", Journal of National Cancer Institute, 43, pp.1159~1164 (1969)
  18. Olin, G. R, "Leukemia and Hodgkin's disease amongSwedish chemistry graduates", Lancet, 2, pp.916~ (1976)
  19. Olin, G. R, "The cancer mortalityamong Swedish chemists graduated during threedecades", Environmental Research, 22, pp.154~161 (1980)
  20. Hoar, S. K, "A retrospective cohortstudy of morality and cancer incidence among chemists", Journal of Occupational Medicine, 23(7), pp.485~494 (1981)
  21. Walrath, J, "Causes of death among femalechemists", American Journal of Public Health, 75(8), pp.883~884 (1985)
  22. Checkoway, H, "Radiation, work experience,cause specific mortality among workers at an energyresearch laboratory", British Journal of IndustrialMedicine, 42, pp.525~533 (1985)
  23. Maher,K.V, "A historical cohortstudy of mortality among chemical researchers", Archives of Environmental Health, 41(2), pp.109~116 (1986)
  24. Cordier, S, "Risk of cancer among laboratory workers", Lancet, 335, pp.1097~ (1990)
  25. Vågerö, D, "Occupationand malignant melanoma: a study based oncancer registration data in England and Wales and inSweden", British Journal of Industrial Medicine, 47, pp.317~324 (1990)
  26. Carpenter, L, "Cancer in laboratory workers", Lancet, 338, pp.1080~1081 (1991)
  27. Cordier, S, "Cancer risk amongworkers in biomedical research. Scandinavian Journalof Work", Environment, and Health, 21, pp.450~459 (1995)
  28. Brown, T. P, "Mortality pattern among biological research laboratoryworkers", British Journal of Industrial Medicine, 73, pp.1152~1155 (1996)
  29. Gustavsson, P, "Mortality and cancer incidence amonglaboratory technicians in medical research and routinelaboratories (Sweden)", Cancer Causes and Control, 10, pp.59~64 (1999)
  30. Wennborg, H, "Mortality and cancerincidence in biomedical laboratory personnel inSweden", American Journal of Industrial Medicine, 35, pp.382~389 (1999)
  31. Wennborg, H, "Cancer incidence andwork place exposure among Swedish biomedicalresearch personnel", International Archives of OccupationalEnvironmental Health, 74, pp.558~564 (2001)
  32. Kauppinen, T, "Exposure to chemical carcinogens and risk ofcancer among Finnish laboratory workers", AmericanJournal of Industrial Medicine, 44, pp.343~350 (2003)
  33. van Barneveld, T. A, "A cohort study of cancer mortalityamong Biology Research Laboratory workers in theNetherlands", Cancer Causes and Control, 15, pp.55~66 (2004)
  34. Kubale, T, "Acohort mortality study of chemical laboratory workersat department of energy nuclear plants", American Journal of Industrial Medicine, 51, pp.656~667 (2008)
  35. Canu, G. I, "Cancer mortalityrisk among biologu research workers in France: firstresults of two retrospective cohort studies", InternationalArchives of Occupational EnvironmentalHealth, 81, pp.777~785 (2008)
  36. Meirik,O, "Major malformations in infants born of women whoworked in laboratories while pregnant", Lancet, 14, pp.91~ (1979)
  37. Holmberg, P. C, "Central-nervous-system defects inchildren born to mothers exposed to organic solventsduring pregnancy", Lancet, 28, pp.177~179 (1979)
  38. Hansson, E., "Pregnancy outcome for women workingin laboratories in some of the pharmaceuticalindustries in Sweden", Scandinavian Journal of Work,Environment, and Health, 6, pp.131~134 (1980)
  39. Axelsson,G., "Pregnancy abnormalities among personnel at avirological laboratory", American Journal of IndustrialMedicine, 1, pp.129~137 (1980)
  40. Ericson, A, "Gastrointestinal atresia and maternal occupationduring pregnancy", Journal of Occupational Medicine, 24, pp.515~518 (1982)
  41. Axelsson,G, "Use of questionnaires in occupational studies of pregnancy outcome", Annals Academy of Medicine Singapore, 13, pp.327~330 (1984)
  42. Axelsson,G, "Exposureto solvents and outcome of pregnancy in universitylaboaratory employees", British Journal of IndustrialMedicine, 41, pp.305~312 (1984)
  43. Ericson, A, "Delivery outcome of womenworking in laboratories during pregnancy", Archives ofEnvironmental Health, 39, pp.5~10 (1984)
  44. Heidam, L. Z, "Spontaneous abortions among laboratoryworkers; a follow up study", Journal of Epidemiologyand Community Health, 38, pp.36~41 (1984)
  45. Taskinen, H, "Laboratorywork and pregnancy outcome", Journal of OccupationalMedicine, 36, pp.311~319 (1994)
  46. Khattak, S, "Pregnancyoutcome following gestational exposure to organicsolvents - A prospective controlled study", Journal ofthe American Medical Association, 281, pp.1106~1109 (1999)
  47. Wennborg, H, "Pregnancy outcome of personnel in Swedish biomedicalresearch laboratories", Journal of Occupationaland Environmental Medicine, 42, pp.438~446 (2000)
  48. Wennborg, H, "Adverse reproduction outcomes among employeesworking in biomedical research laboratories", Scandinavian Journal of Work, Environment, andHealth, 28, pp.5~11 (2002)
  49. Zhu, J. L, "Laboratory work andpregnancy outcomes: a study within the NationalBirth Cohort in Denmark", Occupational EnvironmentalMedicine, 63, pp.53~58 (2006)
  50. Halliday-Bell, "Laboratory work and adversepregnancy outcomes", Occupational Medicine, 60, pp.310~313 (2010)
  51. Wright, W. E, "Organic chemicals and malignant melanoma", AmericanJournal of Industrial Medicine, 4, pp.577~581 (1983)
  52. Chiazze, L, "A historicalcohort study of mortality among salariedresearch and development workers of the Allied Corporation", Journal of Occupational Medicine, 28, pp.1185~1188 (1986)
  53. Divine, B, "Texaco MortalityStudy II : Patterns of mortality among white male byspecific job groups", American Journal of IndustrialMedicine, 10, pp.371~381 (1986)
  54. Olin, G. R, "The hazards of a chemical laboratoryenvironment-a study of the mortality in two cohortsof Swedish chemists", American Industrial HygieneAssociation, 39, pp.557~562 (1978)
  55. Lindbohm, M.-L, "Effects of parental exposure tosolvents on pregnancy outcome", Journal of Occupationaland Environmental Medicine, 37, pp.909~915 (1995)
  56. Kim, J. S, "Studies on MicrobiologicalLaboratory biosafety in Korea - I. A survey onbiosafety status in laboratory", Infection and Chemotherapy, 20(2), pp.133~146 (1988)
  57. 박시영, "해부실습과정에서 노출된 포름알데히드의 건강영향", 대한직업환경의학회지, 18(3), pp.171~178 (2006), 대한직업환경의학회
  58. Lee, H. J, "A survey on safety and health at chemicallaboratories in university", 석사, pp.1996
  59. Kim, M. S, "A study on organic solvent exposure inchemical laboratories of universities", 석사, pp.1997
  60. Yoo, K. M, "A survey and recommendation on safety and healthfor occupational health laboratories", Korean IndustrialHygiene Association Journal, 10(2), pp.150~164 (2000), A survey and recommendation on safety and healthfor occupational health laboratories.Korean IndustrialHygiene Association Journal,10(2),150-164
  61. 하주현, "국내 정부출연연구기관 및 대학교 실험실 공기 오염물질 농도 및 환기시스템 평가", 한국산업위생학회지, 20(1), pp.63~69 (2010), 한국산업위생학회
  62. 하주현, "탄소나노튜브 표면 처리 실험실 종사자의 공기중 나노입자 노출에 관한 연구", 한국환경보건학회지, 36(5), pp.343~350 (2010), 한국환경보건학회
  63. Byun, H. J, "Quantitative assessment strategy for determining theexposures to the volatile organic chemicals in chemistrylaboratories", Journal of Korean Society of Occupationaland Environmental Hygiene. (submitted), ~

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