나노칼슘이 장내 칼슘 흡수 및 골교체율에 미치는 영향
Effects of Nano-sized Calcium on Intestinal Absorption and Bone Turnover
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: We compared the effects of two different nano-sized calcium supplements (synthesized by wet-chemical method or the dry-grinding method of calcium carbonate) and one micro-sized calcium supplement (calcium carbonate) on intestinal absorption and bone turnover in 20 young women. Materials & Methods: This study was carried out with a three week cross-over design. The subjects ingested one of three different calcium supplements (1 dose of 500 mg Ca++) at 8 AM, which was repeated three times weekly. Serum and urine samples were collected before and after the calcium load using a time table (serum sampling 0, 2 hr, 4 hr, 8 hr after loading; urine sampling 0, 4 hr, 8 hr after loading). Results: Serum ionized calcium and parathyroid hormone concentrations significantly changed in response to all calcium supplements loading, the difference among calcium supplements was not significant. However, the postload urinary excretion of calcium and the N-telopeptide/creatinine ratio were significantly different among three calcium supplement over time by repeated measured ANOVA. Conclusions: The results of this study suggest the effect of nano-sized calcium supplements synthesized by the wet-chemical method is superior to the other calcium supplements in intestinal calcium absorption and bone turn-over.
Abstract
Objectives: We compared the effects of two different nano-sized calcium supplements (synthesized by wet-chemical method or the dry-grinding method of calcium carbonate) and one micro-sized calcium supplement (calcium carbonate) on intestinal absorption and bone turnover in 20 young women. Materials & Methods: This study was carried out with a three week cross-over design. The subjects ingested one of three different calcium supplements (1 dose of 500 mg Ca++) at 8 AM, which was repeated three times weekly. Serum and urine samples were collected before and after the calcium load using a time table (serum sampling 0, 2 hr, 4 hr, 8 hr after loading; urine sampling 0, 4 hr, 8 hr after loading). Results: Serum ionized calcium and parathyroid hormone concentrations significantly changed in response to all calcium supplements loading, the difference among calcium supplements was not significant. However, the postload urinary excretion of calcium and the N-telopeptide/creatinine ratio were significantly different among three calcium supplement over time by repeated measured ANOVA. Conclusions: The results of this study suggest the effect of nano-sized calcium supplements synthesized by the wet-chemical method is superior to the other calcium supplements in intestinal calcium absorption and bone turn-over.
참고문헌 (14)
- NIH Consensus Conference, "Optimal calcium intake: NIH consensus development panel on optimal calcium intake", JAMA, 272, pp.1942~1948 (1994)
- WHO, "Diet, nutrition and the prevention of chronic diseases: report of a joint WHO", FAO expert consultation, 2003, pp.916, 1~49
- Ministry of Health and Welfare, "Centers for Disease Control", National Health Statistics: National Health and Nutrition Examination Survey 4th one year, ~ (2007)
- Gueguen L, "The bioavailability of dietary calcium", J Am Coll Nutr, 19, pp.119~136 (2000)
- Heung-Sik Park, "Effect of Nano-Calcium-Enriched Milk on Calcium Metabolism in Ovariectomized Rats", Journal of Medicinal Food, 11(3), pp.454~459 (2008), 한국식품영양과학회
- Boden SD, "Calcium homeostasis", Orthop Clin North Am, 21, pp.31~42 (1990)
- Herfarth K, "Calcium regulating hormones after oral and intravenous calcium administration", Eur J Clin Chem Clin Biochem, 30, pp.815~822 (1992)
- Kärkkäinen MUM, "Postprandial parathyroid hormone response to four calcium-rich foodstuffs", Am J Clin Nutr, 65, pp.1726~1730 (1997)
- Akerström G, "Parathyroid glands in calcium regulation and human disease", Ann N Y Acad Sci, 1040, pp.53~58 (2005)
- Bluhmsohn A, "The effect of calcium supplementation on the circadian rhythm of bone resorption", J Clin Endocrinol Metab, 79, pp.730~735 (1994)
- Charles P, "Calcium absorption and calcium availability", J Intern Med, 231(2), pp.161~168 (1992)
- Heaney RP, "Calcium absorption in women: relationships to calcium intake, estrogen status, and age", J Bone Miner Res, 4(4), pp.469~475 (1989)
- Eyre DR, "Bone biomarkers as tools in osteoporosis management", Spine, 22(24), pp.17~24 (1997)
- Eastell R, "Biological variability of serum and urinary Ntelopeptides of type I collagen in postmenopausal women", Bone Miner Res, 15(3), pp.594~598 (2000)