Effect of Ibandronate and hPTH on the Viscoelastic Response of Ovariectomized Rat Femur
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
PTH and ibandronate are proven to be effective in reversing negative effects of postmenopausal osteoporosis in terms of bone architecture and density. However, the changes of viscoelastic properties of the bone during the pathogenesis of osteoporosis and its treatment were seldom studied. Thus, this study aimed at studying the viscoelastic changes in PTH and ibandronate treated ovariectomized rat to assess the efficacy of the treatments. In this study, distal femurs of twenty-two female rats from four different groups (SHM, OVX, PTH and IBN) were evaluated using CT, pQCT and nanoindentation tests. While density parameters were well preserved in ibandronate treated group, elastic modulus and hardness were found to be better in PTH treated group. Thus, cortical and trabecular bone could be differentially affected by these two categories of drug, due to their difference in the action of mechanism. Moreover, viscosity of the cortical bone showed a positive correlation (R2=0.72) with bone strength predictor SSIy, which would possibly correlate with fracture risk.
Abstract
PTH and ibandronate are proven to be effective in reversing negative effects of postmenopausal osteoporosis in terms of bone architecture and density. However, the changes of viscoelastic properties of the bone during the pathogenesis of osteoporosis and its treatment were seldom studied. Thus, this study aimed at studying the viscoelastic changes in PTH and ibandronate treated ovariectomized rat to assess the efficacy of the treatments. In this study, distal femurs of twenty-two female rats from four different groups (SHM, OVX, PTH and IBN) were evaluated using CT, pQCT and nanoindentation tests. While density parameters were well preserved in ibandronate treated group, elastic modulus and hardness were found to be better in PTH treated group. Thus, cortical and trabecular bone could be differentially affected by these two categories of drug, due to their difference in the action of mechanism. Moreover, viscosity of the cortical bone showed a positive correlation (R2=0.72) with bone strength predictor SSIy, which would possibly correlate with fracture risk.
참고문헌 (20)
- 임도형, "Novel Approach of Predicting Fracture Load in the Human Proximal Femur Using Non-Invasive QCT Imaging Technique", ANNALS OF BIOMEDICAL ENGINEERING, 37(5), pp.966~975, SPRINGER
- Turner CH, "Biomechanics of bone: determinants of skeletal fragility and bone quality", Osteoporos Int, 13, pp.97~104 (2002)
- Consensus development conference, "diagnosis, prophylaxis, and treatment of osteoporosis", Am J Med, 94, pp.646~650 (1993)
- Kanis JA, "The diagnosis of osteoporosis", J Bone Miner Res, 9, pp.1137~1141 (1994)
- Garner E, "Viscoelastic dissipation in compact bone: implications for stress-induced fluid flow in bone", J Biomech Eng, 122, pp.166~172 (2000)
- Kim DG, "Relationships of viscosity with contact hardness and modulus of bone matrix measured by nanoindentation", J Biomech Eng, 132, pp.024502~ (2010)
- Yamashita J, "The use of dynamic mechanical analysis to assess the viscoelastic properties of human cortical bone", J Biomed Mater Res, 58, pp.47~53 (2001)
- Ammann P, "Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength", J Bone Miner Res, 22, pp.1419~1425 (2007)
- Brennan TC, "Selective modification of bone quality by PTH, pamidronate, or raloxifene", J Bone Miner Res, 24, pp.800~808 (2009)
- Iida-Klein A, "Effects of cyclic vs. daily treatment with human parathyroid hormone (1-34) on murine bone structure and cellular activity", Bone, 40, pp.391~398 (2007)
- Miller PD, "Monthly oral ibandronate therapy in postmenopausal osteoporosis: 1-year results from the MOBILE study", J Bone Miner Res, 20, pp.1315~1322 (2005)
- Yang X, "Ibandronate does not reduce the anabolic effects of PTH in ovariectomized rat tibiae: A microarchitectural and mechanical study", Bone, 48, pp.1154~1163 (2011)
- Gittens SA, "Systemic bone formation with weekly PTH administration in ovariectomized rats", J Pharm Pharm Sci, 7, pp.27~ (2004)
- Bauss F, "Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats", J Rheumatol, 29, pp.990~998 (2002)
- Campbell GM, "Signs of irreversible architectural changes occur early in the development of experimental osteoporosis as assessed by in vivo micro-CT", Osteoporos Int, 19, pp.1409~1419 (2008)
- Buie HR, "Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis", Bone, 41, pp.505~515 (2007)
- Laib A, "3D micro- computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis", Med Biol Eng Comput, 38, pp.326~332 (2000)
- Hasegawa Y, "Age, sex, and grip strength determine architectural bone parameters assessed by peripheral quantitative computed tomography (pQCT) at the human radius", J Biomech, 34, pp.497~503 (2001)
- Li X, "A review of nanoindentation continuous stiffness measurement technique and its applications", Materials Characterization, 48, pp.11~ (2002)
- Kokoroghiannis C, "Correlation of pQCT bone strength index with mechanical testing in distraction osteogenesis", Bone, 45, pp.512~516 (2009)