Effects of Zoledronic Acid and Teriparatide on Bone Regeneration After Bone Grafting in Ovariectomized Rat
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Purpose: Osteoporosis, a condition characterized by decreased bone density, increases susceptibility to fractures. This study aimed to evaluate the early and mid-term effects of zoledronic acid and teriparatide on bone regeneration in rats with osteoporosis. Materials and Methods: Osteoporosis was induced in rats through ovariectomy, after which animals were randomly divided into four groups: TPD_2, TPD_4, ZA_2, and ZA_4. Calvarial bone grafting was performed eight weeks after ovariectomy. All animals were sacrificed 2 or 4 weeks after zoledronic acid and teriparatide administration. The tibia and calvaria were harvested for analysis. Results: In the calvaria, the volume fraction of newly formed bone was significantly higher in the ZA_4 group compared to the ZA_2 and TPD_2 groups. The specific bone surface area of residual grafts was significantly lower in the TPD_4 group compared to the ZA_2 and ZA_4 groups. The percentage of newly formed bone in the calvaria was significantly higher in the TPD_2 group compared to the ZA_2 group. Conclusion: Teriparatide plays a role in bone formation during the early stages of bone grafting particularly when bone formation is inhibited. These findings suggest that teriparatide may enhance the success rate of bone transplantation and accelerate the healing process.
Abstract
Purpose: Osteoporosis, a condition characterized by decreased bone density, increases susceptibility to fractures. This study aimed to evaluate the early and mid-term effects of zoledronic acid and teriparatide on bone regeneration in rats with osteoporosis. Materials and Methods: Osteoporosis was induced in rats through ovariectomy, after which animals were randomly divided into four groups: TPD_2, TPD_4, ZA_2, and ZA_4. Calvarial bone grafting was performed eight weeks after ovariectomy. All animals were sacrificed 2 or 4 weeks after zoledronic acid and teriparatide administration. The tibia and calvaria were harvested for analysis. Results: In the calvaria, the volume fraction of newly formed bone was significantly higher in the ZA_4 group compared to the ZA_2 and TPD_2 groups. The specific bone surface area of residual grafts was significantly lower in the TPD_4 group compared to the ZA_2 and ZA_4 groups. The percentage of newly formed bone in the calvaria was significantly higher in the TPD_2 group compared to the ZA_2 group. Conclusion: Teriparatide plays a role in bone formation during the early stages of bone grafting particularly when bone formation is inhibited. These findings suggest that teriparatide may enhance the success rate of bone transplantation and accelerate the healing process.
참고문헌 (27)
- Eastell R, "Postmenopausal osteoporosis", Nat Rev Dis Primers, 2, pp.16069~ (2016)
- Dobnig H, "Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells", Endocrinology, 136, pp.3632~3638 (1995)
- Green JR, "Bisphosphonates : preclinical review", Oncologist, 9(Suppl 4), pp.3~13 (2004)
- Hornby SB, "Long-term zoledronic acid treatment increases bone structure and mechanical strength of long bones of ovariectomized adult rats", Calcif Tissue Int, 72, pp.519~527 (2003)
- Reszka AA, "Bisphosphonate mechanism of action", Curr Rheumatol Rep, 5, pp.65~74 (2003)
- Jilka RL, "Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone", J Clin Invest, 104, pp.439~446 (1999)
- Silva BC, "Parathyroid hormone : anabolic and catabolic actions on the skeleton", Curr Opin Pharmacol, 22, pp.41~50 (2015)
- Silva ED, "Intermittent administration of parathyroid hormone improves the repairing process of rat calvaria defects : A histomorphometric and radiodensitometric study", Med Oral Patol Oral Cir Bucal, 20, pp.e489~e493 (2015)
- Hodsman AB, "Parathyroid hormone and teriparatide for the treatment of osteoporosis : a review of the evidence and suggested guidelines for its use", Endocr Rev, 26, pp.688~703 (2005)
- Park KM, "Preventive effect of teriparatide on medication-related osteonecrosis of the jaw in rats", Sci Rep, 13, pp.15518~ (2023)
- Park KM, "Medication-related osteonecrosis of the jaw using periodontitis-induced rat before tooth extraction", BMC Oral Health, 23, pp.561~ (2023)
- Gunes N, "Systemic and local zoledronic acid treatment with hydroxyapatite bone graft : A histological and histomorphometric experimental study", Exp Ther Med, 12, pp.2417~2422 (2016)
- Jee JH, "The influence of alendronate on the healing of extraction sockets of ovariectomized rats assessed by in vivo micro-computed tomography", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 110, pp.e47~e53 (2010)
- Schmitz JP, "The critical size defect as an experimental model for craniomandibulofacial nonunions", Clin Orthop Relat Res, pp.299~308 (1986)
- Takagi K, "The reaction of the dura to bone morphogenetic protein(BMP)in repair of skull defects", Ann Surg, 196, pp.100~109 (1982)
- Mardas N, "Bone and suture regeneration in calvarial defects by e-PTFE-membranes and demineralized bone matrix and the impact on calvarial growth : an experimental study in the rat", J Craniofac Surg, 13, pp.453~462 (2002)
- Bartlow CM, "PTH(1-34)and zoledronic acid have differing longitudinal effects on juvenile mouse femur strength and morphology", J Orthop Res, 35, pp.1707~1715 (2017)
- Doh RM, "Postoperative irradiation after implant placement : A pilot study for prosthetic reconstruction", J Adv Prosthodont, 8, pp.363~371 (2016)
- on calvarial bone graft in irradiated rat, "Oral Dis", 2019, 822~830
- Park KM, "Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats", Biomed Res Int, 2019, pp.9051713~ (2019)
- Kim HC, "Combined effect of bisphosphonate and recombinant human bone morphogenetic protein 2 on bone healing of rat calvarial defects", Maxillofac Plast Reconstr Surg, 37, pp.16~ (2015)
- Toker H, "A comparative evaluation of the systemic and local alendronate treatment in synthetic bone graft : a histologic and histomorphometric study in a rat calvarial defect model", Oral Surg Oral Med Oral Pathol Oral Radiol, 114, pp.S146~S152 (2012)
- Gasser JA, "Long-term protective effects of zoledronic acid on cancellous and cortical bone in the ovariectomized rat", J Bone Miner Res, 23, pp.544~551 (2008)
- Tsunori K, "Effects of intermittent administration of parathyroid hormone on bone augmentation in rat calvarium", Implant Dent, 24, pp.142~148 (2015)
- Kuroshima S, "Parathyroid hormone related to bone regeneration in grafted and nongrafted tooth extraction sockets in rats", Implant Dent, 22, pp.71~76 (2013)
- Hock JM, "Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone", J Bone Miner Res, 7, pp.65~72 (1992)
- Yun JI, "Effect of systemic parathyroid hormone(1-34)and a beta-tricalcium phosphate biomaterial on local bone formation in a critical-size rat calvarial defect model", J Clin Periodontol, 37, pp.419~426 (2010)