Orthodontic Tooth Movement in the Osteoporotic Rat Maxilla by Local Application of Human Parathyroid Hormone
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
This study aimed to investigate the effect of parathyroid hormone (PTH) on tooth movement in an osteoporotic rat by comparing of the tooth movement distances and histologic observation. Fifteen, 8-week-old female rats were classified into three groups (n=5, respectively): (1) sham-operated control group, (2) ovariectomized group (OVX), and (3) ovariectomized rats injected with 30 μg/kg of PTH group (PTH). To induce the orthodontic tooth movement, a closedcoil spring appliance was placed and activated with the continuous force of 50 cN to the maxillary first molar. During the experimental period, the amount of tooth movement was measured at 7, 14, 21 days and all rats were sacrificed for histologic specimen preparation. The OVX group showed the fastest tooth movement, and the distance of tooth movement in the OVX group was significantly greater than that in the other two groups at 14 and 21 days (P=0.00 and P=0.02, respectively). The histologic sections revealed the evidence of osteopenia in both the OVX and PTH than the control group. And there was tendency to enhanced bone turnover in the inter-radicular bone of the PTH group. In summary, PTH treatment did not promote tooth movement in the osteoporotic rat model but showed the increased bone turnover. Therefore, further study is required to consider the clinical application of PTH during orthodontic treatment.
Abstract
This study aimed to investigate the effect of parathyroid hormone (PTH) on tooth movement in an osteoporotic rat by comparing of the tooth movement distances and histologic observation. Fifteen, 8-week-old female rats were classified into three groups (n=5, respectively): (1) sham-operated control group, (2) ovariectomized group (OVX), and (3) ovariectomized rats injected with 30 μg/kg of PTH group (PTH). To induce the orthodontic tooth movement, a closedcoil spring appliance was placed and activated with the continuous force of 50 cN to the maxillary first molar. During the experimental period, the amount of tooth movement was measured at 7, 14, 21 days and all rats were sacrificed for histologic specimen preparation. The OVX group showed the fastest tooth movement, and the distance of tooth movement in the OVX group was significantly greater than that in the other two groups at 14 and 21 days (P=0.00 and P=0.02, respectively). The histologic sections revealed the evidence of osteopenia in both the OVX and PTH than the control group. And there was tendency to enhanced bone turnover in the inter-radicular bone of the PTH group. In summary, PTH treatment did not promote tooth movement in the osteoporotic rat model but showed the increased bone turnover. Therefore, further study is required to consider the clinical application of PTH during orthodontic treatment.
참고문헌 (30)
- Krishnan V, "Cellular, molecular, and tissue-level reactions to orthodontic force", Am J Orthod Dentofacial Orthop, 129, pp.469e1~469e32 (2006)
- Wise GE, "Mechanisms of tooth eruption and orthodontic tooth movement", J Dent Res, 87, pp.414~434 (2008)
- Bartzela T, "Medication effects on the rate of orthodontic tooth movement : a systematic literature review", Am J Orthod Dentofacial Orthop, 135, pp.16~26 (2009)
- Tyrovola JB, "Effects of drugs and systemic factors on orthodontic treatment", Quintessence Int, 32, pp.365~371 (2001)
- Andrade I Jr., "CCR5 down-regulates osteoclast function in orthodontic tooth movement", J Dent Res, 88, pp.1037~1041 (2009)
- Fujimura Y, "Influence of bisphosphonates on orthodontic tooth movement in mice", Eur J Orthod, 31, pp.572~577 (2009)
- Karras JC, "Effect of alendronate on orthodontic tooth movement in rats", Am J Orthod Dentofacial Orthop, 136, pp.843~847 (2009)
- Zahrowski JJ, "Optimizing orthodontic treatment in patients taking bisphosphonates for osteoporosis", Am J Orthod Dentofacial Orthop, 135, pp.361~374 (2009)
- Jilka RL, "Molecular and cellular mechanisms of the anabolic effect of intermittent PTH", Bone, 40, pp.1434~1446 (2007)
- Neer RM, "Effect of parathyroid hormone(1-34)on fractures and bone mineral density in postmenopausal women with osteoporosis", N Engl J Med, 344, pp.1434~1441 (2001)
- Lombardi G, "The roles of parathyroid hormone in bone remodeling : prospects for novel therapeutics", J Endocrinol Invest, 34, pp.18~22 (2011)
- Poole KE, "Parathyroid hormone-a bone anabolic and catabolic agent", Curr Opin Pharmacol, 5, pp.612~617 (2005)
- Soma S, "Effects of continuous infusion of PTH on experimental tooth movement in rats", J Bone Miner Res, 14, pp.546~554 (1999)
- Soma S, "Local and chronic application of PTH accelerates tooth movement in rats", J Dent Res, 79, pp.1717~1724 (2000)
- Salazar M, "Effect of teriparatide on induced tooth displacement in ovariectomized rats : a histomorphometric analysis", Am J Orthod Dentofacial Orthop, 139, pp.e337~44 (2011)
- Follin SL, "Current approaches to the prevention and treatment of postmenopausal osteoporosis", Am J Health Syst Pharm, 60, pp.883~901 (2003)
- Hirate Y, "Effects of relaxin on relapse and periodontal tissue remodeling after experimental tooth move-ment in rats", Connect Tissue Res, 53, pp.207~219 (2012)
- Leung FY, "Osteoporosis, osteonecrosis, and orthodontics", World J Orthod, 10, pp.261~271 (2009)
- Johal A, "The impact of orthodontic treatment on quality of life and self-esteem in adult patients", Eur J Orthod, 37, pp.233~237 (2015)
- Choi J, "Effects of clodronate on early alveolar bone remodeling and root resorption related to ortho-dontic forces : a histomorphometric analysis", Am J Orthod Dentofacial Orthop, 138, pp.548~ (2010)
- Misawa Y, "Effect of age on alveolar bone turnover adjacent to maxillary molar roots in male rats : A histomorphometric study", Arch Oral Biol, 52, pp.44~50 (2007)
- Miyajima K, "Orthodontic treatment for a patient after menopause", Angle Orthod, 66, pp.173~178 (1996)
- Riggs BL, "The prevention and treatment of osteoporosis", N Engl J Med, 327, pp.620~627 (1992)
- Sirisoontorn I, "Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid", Am J Orthod Dentofacial Orthop, 141, pp.563~573 (2012)
- Sirisoontorn I, "Tooth movement and root resorption; the effect of ovariectomy on orthodontic force application in rats", Angle Orthod, 81, pp.570~577 (2011)
- Sidiropoulou-Chatzigiannis S, "The effect of osteoporosis on periodontal status, alveolar bone and ortho-dontic tooth movement. A literature review", J Int Acad Periodontol, 9, pp.77~84 (2007)
- Ashcraft MB, "The effect of corticosteroid-induced osteoporosis on orthodontic tooth movement", Am J Orthod Dentofacial Orthop, 102, pp.310~319 (1992)
- Yamashiro T, "Influences of Ovariectomy on Experimental Tooth Movement in the Rat", J Dent Res, 80, pp.1858~1861 (2001)
- Doh RM, "Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw associated with dental implants", Implant Dent, 24, pp.222~226 (2015)
- von Bohl M, "Focal hyalinization during experimental tooth movement in beagle dogs", Am J Orthod Dentofacial Orthop, 125, pp.615~623 (2004)