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고상추출법과 액체크로마토그래프 질량분석장치를 이용한 수질시료에서의 의약물질 분석

Analysis of Pharmaceutical Compounds in Water using Solid Phase Extraction (SPE) and Liquid Chromatography/Mass Spectrometry (LC/MS)

오정은|심원진|이은영
한국환경분석학회 (The Korean Society For Environmental Analysis)|2008.06|환경분석과 독성보건 (JOURNAL OF ENVIRONMENTAL ANALYSIS, HEALTH AND TOXICOLOGY)|제11권 제2호|pp. 130-143

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참고문헌

키워드

pharmacueticalssewage treatment plants (STPs)Liquid Chromatography/Mass Spectrometry (LC/MS)Solid Phase Extraction (SPE)

초록

SPE (solid-phase extraction) and LC/MS (liquid chromatography/mass spectrometry) method has been developed for the analysis of thirty three pharmaceuticals in aqueous sample, such as sewage and river water. The effects of disk type and pH on the extraction of pharmaceuticals in water were examined. Hydrophilic DVB disk was more efficient than otadecyl (C18) disk and the extraction efficiency of pharmaceuticals at pH=2 (53-139%) was better than that at pH=5. Thirty three pharmaceutics in sewage influent, effluent and river sample were analyzed using the method developed in this study. Fourteen drugs (acetaminophen, acetylsalicylic acid, diclofenac-Na, ibuprofen, ketoprofen, mefenamic acid, naproxen, carbamazepine, clofibric acid, gemfibrozil, caffeine, erythromycin-H₂O, lincomycin, and amoxicillin) were detected and the levels of detection were 0.001~10.1 ppb (μg/L).

Abstract

SPE (solid-phase extraction) and LC/MS (liquid chromatography/mass spectrometry) method has been developed for the analysis of thirty three pharmaceuticals in aqueous sample, such as sewage and river water. The effects of disk type and pH on the extraction of pharmaceuticals in water were examined. Hydrophilic DVB disk was more efficient than otadecyl (C18) disk and the extraction efficiency of pharmaceuticals at pH=2 (53-139%) was better than that at pH=5. Thirty three pharmaceutics in sewage influent, effluent and river sample were analyzed using the method developed in this study. Fourteen drugs (acetaminophen, acetylsalicylic acid, diclofenac-Na, ibuprofen, ketoprofen, mefenamic acid, naproxen, carbamazepine, clofibric acid, gemfibrozil, caffeine, erythromycin-H₂O, lincomycin, and amoxicillin) were detected and the levels of detection were 0.001~10.1 ppb (μg/L).

참고문헌 (33)

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