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LC-MS/MS를 이용한 수질 시료에서의 43종 미규제 미량오염물질동시 분석 가능성 및 실제 시료 적용성 평가

Evaluation of the Simultaneous Analytical Method and its Applicability for43 Unregulated Trace Contaminants in Water Samples Using LC-MS/MS

오정은|이헌준|노효준|문해란
한국환경분석학회 (The Korean Society For Environmental Analysis)|2024.12|환경분석과 독성보건 (JOURNAL OF ENVIRONMENTAL ANALYSIS, HEALTH AND TOXICOLOGY)|제27권 제4호|pp. 225-237|DOI https://doi.org/10.36278/jeaht.27.4.225

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키워드

PharmaceuticalsLC-MS/MSPesticidesTrace contaminants

초록

this study, a solid-phase extraction (SPE) method with a multi-layer cartridge was employed for the simultaneous analysis of river water for 21 pharmaceuticals and 22 pesticides. Accuracy, precision and recovery of internal standards were satisfactory and met the requirements of the EPA Method 1694. In the case of amoxicillin, analytical conditions were optimized using methanol adduct as a precursor ion, resulting in higher analytical sensitivity than the original compound. The method detection limits (MDLs) were similar to or lower than those reported in domestic and international studies. When the simultaneous analytical method used in this study was applied to river water samples, 25 out of 43 target compounds were detected. Although their concentration levels are about 100 times lower than international water quality standards, continuous monitoring is required due to the high detection frequency of some compounds for which domestic research data are lacking.

Abstract

this study, a solid-phase extraction (SPE) method with a multi-layer cartridge was employed for the simultaneous analysis of river water for 21 pharmaceuticals and 22 pesticides. Accuracy, precision and recovery of internal standards were satisfactory and met the requirements of the EPA Method 1694. In the case of amoxicillin, analytical conditions were optimized using methanol adduct as a precursor ion, resulting in higher analytical sensitivity than the original compound. The method detection limits (MDLs) were similar to or lower than those reported in domestic and international studies. When the simultaneous analytical method used in this study was applied to river water samples, 25 out of 43 target compounds were detected. Although their concentration levels are about 100 times lower than international water quality standards, continuous monitoring is required due to the high detection frequency of some compounds for which domestic research data are lacking.

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