개의 외이도염에서 분리한 진균과 세균에 대한 약제 감수성
Drug sensitivities to fungi and bacteria from otitis externa in dogs
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초록
외이도염으로 진단된 개의 92례의 병소로 부터 세균 분리 및 진균분리를 실시한 결과 세균 126주 중 가장 많은 것이 Staphyolococcus spp.이었고 다음이 Pseudomonas spp., Corynabacterium spp.와 Streptococcus canis의 순서이었다.진균류는 Malassezia pachydermatis가 전부이었고, Malassezia pachydermatis의 항진균제 9종에 대한 감수성은 Ketoconazole이 가장 높은 최소 발욕저지농도(MIC)를, 다음이 miconazol nitrate와 amphotericin B에 대해서는 높은 감수성을 나타내었으나 다른 약제에 대해서는 내성이 나타났다.분리세균중에서 항균제 11종에 대한 약제 감수성은 Streptococcus canis와 Pseudomonas spp.를 비롯한 포도당 비발효균에서 여러약제에 대한 내성균이 다수 있었고 Orbifloxacin에만 감수성을 나타내는 세균은 다수 있어 진균 외이도염에서 Malassezia pachydermatis의 여러 세균이 있었고 약제 내성균주도 많아 처치시에는 철저한 분리와 약제 내성검사는 필수적으로 판단된다.
Abstract
Samples of otitis externa attempts were made to isolate bacteria from 92 dogs diagnosed as otitis externa at the animal hospital and the minimum inhibitory concentration (MIC) of antifungal and antibacterial agents against these isolates were determined. Malassezia pachydermatis was isolated from the external acoustic meatus lesions at a rate 70% (60 strains). In the sensitivity tests to nine antifungal agents, ketoconazol gave the lowest MICs to these isolates, followed by miconazol nitrate and amphotericin B, but the siolates were resistant to other agents. Among 126 bacterial strains siolated from the external acoustic meatus lesions, the most predominant species were Staphylococcus spp., followed by Pseudomonas spp., Corynebacterium spp. and Streptococcus canis in this order. In the sensitivity tests of these isolates using 11 kinds of antibacterial agents, multiple drug resistance was found in many of such glucose nonfermenting organisms as Pseudomonas spp. and Streptococcus canis, and many of the isolates were sensitive to orbifloxacin only. In the present study, Malassezia pachydermatis and bacteria were isolated from many dogs suffering from otitis externa and many of the isolates were resistant to multiple drugs.
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