Middle East Respiratory Syndrome Coronavirus Infection in Children
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Since 2012, outbreaks of the Middle East respiratory coronavirus (MERS-CoV) have been reported, including the Republic of Korea. To date, most of the people infected with the virus are adults. Herein we describe the clinical characteristics of cases of MERS-CoV infection among children. As of October 29, 2015, MERS-CoV has caused 34 pediatric infections, which accounts for 2.1% of all cases. The median age was 13 years (range 9 months to 17 years) and where gender has been reported (n=33), 57.6% cases were male. About half of the patients were asymptomatic and the majority of the symptomatic patients had respiratory symptoms. In general, the clinical outcome in children was favorable. Among the four patients who died of progressive pneumonia, three had documented comorbidities. MERS-CoV infection in children has a lower incidence and mortality compared to adults.
Abstract
Since 2012, outbreaks of the Middle East respiratory coronavirus (MERS-CoV) have been reported, including the Republic of Korea. To date, most of the people infected with the virus are adults. Herein we describe the clinical characteristics of cases of MERS-CoV infection among children. As of October 29, 2015, MERS-CoV has caused 34 pediatric infections, which accounts for 2.1% of all cases. The median age was 13 years (range 9 months to 17 years) and where gender has been reported (n=33), 57.6% cases were male. About half of the patients were asymptomatic and the majority of the symptomatic patients had respiratory symptoms. In general, the clinical outcome in children was favorable. Among the four patients who died of progressive pneumonia, three had documented comorbidities. MERS-CoV infection in children has a lower incidence and mortality compared to adults.
참고문헌 (15)
- Zaki AM, "Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia", N Engl J Med, 367, pp.1814~1820 (2012)
- "Middle East respiratory syndrome coronavirus (MER-CoV) outbreak news" (2015)[URL]
- "Middle East respiratory syndrome coronavirus (MERS-CoV): Summary of current situation, literature update and risk assessment" (2015)[URL]
- Memish ZA, "Middle East respiratory syndrome coronavirus disease in children", Pediatr Infect Dis J, 33, pp.904~906 (2014)
- Thabet F, "Middle East respiratory syndrome coronavirus in children", Saudi Med J, 36, pp.484~486 (2015)
- Banik GR, "Middle East respiratory syndrome coronavirus “MERS-CoV”: Current knowledge gaps", Paediatr Respir Rev, 16, pp.197~202 (2015)
- "Command and Control Center Statistics" (2015)[URL]
- Assiri A, "Hospital outbreak of Middle East respiratory syndrome coronavirus", N Engl J Med, 369, pp.407~416 (2013)
- Oboho IK, "2014 MERS-CoV outbreak in Jeddah--a link to health care facilities", N Engl J Med, 372, pp.846~854 (2015)
- Chowell G, "Synthesizing data and models for the spread of MERS-CoV, 2013: key role of index cases and hospital transmission", Epidemics, 9, pp.40~51 (2014)
- Zumla A, "Middle East respiratory syndrome", Lancet, 386, pp.995~1007 (2015)
- The WHO MERS-CoV Research Group, "State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans", PLoS Curr (2013)[DOI]
- Assiri A, "Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study", Lancet Infect Dis, 13, pp.752~761 (2013)
- Al-Tawfiq JA, "Middle East respiratory syndrome coronavirus:a case-control study of hospitalized patients", Clin Infect Dis, 59, pp.160~165 (2014)
- Korea Centers for Disease Control and Prevention, "Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea, 2015", Osong Public Health Res Perspect, 6, pp.269~278 (2015)