Human Coronavirus in the 2014 Winter Season as a Cause of Lower Respiratory Tract Infection
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: During the late autumn to winter season (October to December) in the Republic of Korea, respiratory syncytial virus (RSV) is the most common pathogen causing lower respiratory tract infections (LRTIs). Interestingly, in 2014, human coronavirus (HCoV) caused not only upper respiratory infections but also LRTIs more commonly than in other years. Therefore, we sought to determine the epidemiology, clinical characteristics, outcomes, and severity of illnesses associated with HCoV infections at a singlecenter in Korea. Materials and Methods: We retrospectively identified patients with positive HCoV respiratory specimens between October 2014 and December 2014 who were admitted to Severance Children’s Hospital at Yonsei University Medical Center for LRTI. Charts of the patients with HCoV infection were reviewed and compared with RSV infection. Results: During the study period, HCoV was the third most common respiratory virus and accounted for 13.7% of infections. Co-infection was detected in 43.8% of children with HCoV. Interestingly, one patient had both HCoV-OC43 and HCoV-NL63. Mild pneumonia was most common (60.4%) with HCoV, and when combined with RSV, resulted in bronchiolitis. Two patients requiredcare in the intensive care unit. However, compared with that of RSV infection, the disease course HCoV was short. Conclusion: Infections caused by HCoVs are common, and can cause LRTIs. During an epidemic season, clinicians should be given special consideration thereto. When combined with other medical conditions, such as neurologic or cardiologic diseases, intensive care unit (ICU) care may be necessary.
Abstract
Purpose: During the late autumn to winter season (October to December) in the Republic of Korea, respiratory syncytial virus (RSV) is the most common pathogen causing lower respiratory tract infections (LRTIs). Interestingly, in 2014, human coronavirus (HCoV) caused not only upper respiratory infections but also LRTIs more commonly than in other years. Therefore, we sought to determine the epidemiology, clinical characteristics, outcomes, and severity of illnesses associated with HCoV infections at a singlecenter in Korea. Materials and Methods: We retrospectively identified patients with positive HCoV respiratory specimens between October 2014 and December 2014 who were admitted to Severance Children’s Hospital at Yonsei University Medical Center for LRTI. Charts of the patients with HCoV infection were reviewed and compared with RSV infection. Results: During the study period, HCoV was the third most common respiratory virus and accounted for 13.7% of infections. Co-infection was detected in 43.8% of children with HCoV. Interestingly, one patient had both HCoV-OC43 and HCoV-NL63. Mild pneumonia was most common (60.4%) with HCoV, and when combined with RSV, resulted in bronchiolitis. Two patients requiredcare in the intensive care unit. However, compared with that of RSV infection, the disease course HCoV was short. Conclusion: Infections caused by HCoVs are common, and can cause LRTIs. During an epidemic season, clinicians should be given special consideration thereto. When combined with other medical conditions, such as neurologic or cardiologic diseases, intensive care unit (ICU) care may be necessary.
참고문헌 (18)
- Malave A, "Severe Acute Respiratory Syndrome (SARS)-lessons for future pandemics", Virtual Mentor, 12, pp.719~725 (2010)
- Cleri DJ, "Severe acute respiratory syndrome (SARS)", Infect Dis Clin North Am, 24, pp.175~202 (2010)
- Kim T, "Transmission among healthcare worker contacts with a Middle East respiratory syndrome patient in a single Korean centre", Clin Microbiol Infect, 22, pp.e11~e13 (2016)
- Ki M, "2015 MERS outbreak in Korea: hospital-to-hospital transmission", Epidemiol Health, 37, pp.e2015033~ (2015)
- Mclntosh K, "Feigin and Cherry’s Textbook of pediatric infectious diseases", pp.2486~2495 (2014), Saunders Elsevier
- Dijkman R, "The dominance of human coronavirus OC43 and NL63 infections in infants", J Clin Virol, 53, pp.135~139 (2012)
- 함희진, "Infection Frequency and Mixed infection on Eight Viruses from Patients with Acute Respiratory Syndromes in Seoul", Journal of Bacteriology and Virology, 44(3), pp.274~282 (2014), 대한미생물학회[DOI]
- 함희진, "서울지역 급성 호흡기 환자들로부터 분리한 호흡기 바이러스의 유행양상", Annals of Clinical Microbiology, 16(4), pp.188~195 (2013), 대한임상미생물학회
- Chiu SS, "Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China", Clin Infect Dis, 40, pp.1721~1729 (2005)
- Kristoffersen AW, "Coronavirus causes lower respiratory tract infections less frequently than RSV in hospitalized Norwegian children", Pediatr Infect Dis J, 30, pp.279~283 (2011)
- Lee J, "Characterization of human coronavirus OC43and human coronavirus NL63 infections among hospitalized children <5 years of age", Pediatr Infect Dis J, 33, pp.814~820 (2014)
- Greenberg SB, "Update on rhinovirus and coronavirus infections", Semin Respir Crit Care Med, 32, pp.433~446 (2011)
- Gallaher S, "SARS: what we have learned so far", Dimens Crit Care Nurs, 24, pp.51~54 (2005)
- van der Hoek L, "Identification of a new human coronavirus", Nat Med, 10, pp.368~373 (2004)
- Pyrc K, "Identification of new human coronaviruses", Expert Rev Anti Infect Ther, 5, pp.245~253 (2007)
- Liu T, "Viral Etiology of acute respiratory tract infections in hospitalized children and adults in Shandong Province, China", Virol J, 12, pp.168~ (2015)
- Ge X, "Characterization of acute respiratory infections among 340 infants in Wuxi, Jiangsu Province", Ann Transl Med, 3, pp.264~ (2015)
- Debiaggi M, "The role of infections and coinfections with newly identified and emerging respiratory viruses in children", Virol J, 9, pp.247~ (2012)