Clinical and Epidemiological Characteristics of Common Human Coronaviruses in Children: A Single Center Study, 2015–2019
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: Common human coronaviruses (HCoVs) are relatively understudied due to the mild nature of HCoV infection. Given the lack of local epidemiology data on common HCoVs, we aimed to describe clinical and epidemiological characteristics of common HCoVs in children. Methods: Respiratory viral test results from 9,589 respiratory samples from Seoul National University Children's Hospital were analyzed from January 2015 to December 2019. Viral detection was done by the multiplex reverse transcription polymerase chain reaction. Demographics and clinical diagnosis were collected for previously healthy children tested positive for HCoVs. Results: Of the 9,589 samples tested, 1 or more respiratory viruses were detected from 5,017 (52.3%) samples and 463 (4.8%) samples were positive for HCoVs (OC43 2.8%, NL63 1.4%, 229E 0.7%). All 3 types co-circulated during winter months (November to February) with some variation by type. HCoV-OC43 was the most prevalent every winter season. HCoV-NL63 showed alternate peaks in late winter (January to March) and early winter (November to February). HCoV-229E had smaller peaks every other winter. Forty-one percent of HCoV-positive samples were co-detected with additional viruses; human rhinovirus 13.2%, respiratory syncytial virus 13.0%, influenza virus 4.3%. Common clinical diagnosis was upper respiratory tract infection (60.0%) followed by pneumonia (14.8%), croup (8.1%), and bronchiolitis (6.7%). Croup accounted for 17.0% of HCoV-NL63-positive children. Conclusions: This study described clinical and epidemiological characteristics of common HCoVs (OC43, NL63, 229E) in children. Continuing surveillance, perhaps by adding HKU1 in the diagnostic panel can further elucidate the spectrum of common HCoV infections in children.
Abstract
Purpose: Common human coronaviruses (HCoVs) are relatively understudied due to the mild nature of HCoV infection. Given the lack of local epidemiology data on common HCoVs, we aimed to describe clinical and epidemiological characteristics of common HCoVs in children. Methods: Respiratory viral test results from 9,589 respiratory samples from Seoul National University Children's Hospital were analyzed from January 2015 to December 2019. Viral detection was done by the multiplex reverse transcription polymerase chain reaction. Demographics and clinical diagnosis were collected for previously healthy children tested positive for HCoVs. Results: Of the 9,589 samples tested, 1 or more respiratory viruses were detected from 5,017 (52.3%) samples and 463 (4.8%) samples were positive for HCoVs (OC43 2.8%, NL63 1.4%, 229E 0.7%). All 3 types co-circulated during winter months (November to February) with some variation by type. HCoV-OC43 was the most prevalent every winter season. HCoV-NL63 showed alternate peaks in late winter (January to March) and early winter (November to February). HCoV-229E had smaller peaks every other winter. Forty-one percent of HCoV-positive samples were co-detected with additional viruses; human rhinovirus 13.2%, respiratory syncytial virus 13.0%, influenza virus 4.3%. Common clinical diagnosis was upper respiratory tract infection (60.0%) followed by pneumonia (14.8%), croup (8.1%), and bronchiolitis (6.7%). Croup accounted for 17.0% of HCoV-NL63-positive children. Conclusions: This study described clinical and epidemiological characteristics of common HCoVs (OC43, NL63, 229E) in children. Continuing surveillance, perhaps by adding HKU1 in the diagnostic panel can further elucidate the spectrum of common HCoV infections in children.
참고문헌 (17)
- van der Hoek L, "Human coronaviruses : what do they cause", Antivir Ther, 12, pp.651~658 (2007)
- Mäkelä MJ, "Viruses and bacteria in the etiology of the common cold", J Clin Microbiol, 36, pp.539~542 (1998)
- Killerby ME, "Human coronavirus circulation in the United States 2014–2017", J Clin Virol, 101, pp.52~56 (2018)
- Sung JY, "Role of human coronavirus NL63 in hospitalized children with croup", Pediatr Infect Dis J, 29, pp.822~826 (2010)
- Lee WJ, "Prevalence and molecular epidemiology of human coronavirus HKU1 in patients with acute respiratory illness", J Med Virol, 85, pp.309~314 (2013)
- 김금향, "하기도 감염으로 입원한 소아에서 12종 바이러스의 검출 및 임상 양상", Clinical and Experimental Pediatrics, 51(8), pp.834~841 (2008), 대한소아청소년과학회
- Dare RK, "Human coronavirus infections in rural Thailand : a comprehensive study using real-time reverse-transcription polymerase chain reaction assays", J Infect Dis, 196, pp.1321~1328 (2007)
- "Public Health Weekly Report 2015–2019" (2015)[URL]
- "The National Respiratory and Enteric Virus Surveillance System (NREVSS) 2019–2020" (2019)[URL]
- Kissler SM, "Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period", Science, 368, pp.860~868 (2020)
- Sette A, "Pre-existing immunity to SARS-CoV-2 : the knowns and unknowns", Nat Rev Immunol, 20, pp.457~458 (2020)
- Ma Z, "Cross-reactivity towards SARS-CoV-2 : the potential role of low-pathogenic human coronaviruses", Lancet Microbe, 1, pp.e151~ (2020)
- Hicks J, "Serologic cross-reactivity of SARS-CoV-2 with endemic and seasonal Betacoronaviruses", J Clin Immunol, 41, pp.906~913 (2021)
- Grifoni A, "Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals", Cell, 181, pp.1489~1501 (2020)
- Britton T, "A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2", Science, 369, pp.846~849 (2020)
- Randolph HE, "Herd immunity : understanding COVID-19", Immunity, 52, pp.737~741 (2020)
- 서유빈, "Etiology and Clinical Outcomes of Acute Respiratory Virus Infection in Hospitalized Adults", Infection and Chemotherapy, 46(2), pp.67~76 (2014), 대한감염학회[DOI]