New Method of Quantitative Analysis of Hard Exudate Using Optical Coherence Tomography: Application in Diabetic Macular Edema
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Purpose: In the present study, the volume of hard exudates (HEs) was quantitatively measured using optical coherencetomography (OCT) and the agreement and correlation with area of HEs in fundus photography wereanalyzed. Methods: The medical records of patients with diabetic macular edema who underwent focal laser treatmentand were followed up more than 3 months were retrospectively evaluated. An automated customized programdesigned for measuring HE volume was used. The HEs in each OCT B-scan binary image were measuredusing 512 × 128 pixels, 6 mm × 6 mm OCT cube scans. The volume was measured by summing the segmentedHEs in each 128 B-scan image. The area was measured in 6 mm x 6 mm fundus photography. The volumeand area were measured before and 3 months after the treatment. The agreement of increase and decreasein HEs, and the correlation of volume and area of HEs were analyzed. Results: A total of 35 patients (39 eyes) were included in the study. The volume was significantly reduced from0.07978 to 0.02565 mm3 at 3 months (p < 0.001). The area was also significantly reduced from 15.35 to 8.60mm2 at 3 months (p < 0.001). The volume was decreased in 34 eyes and increased in 5 eyes. The area wasdecreased in 37 eyes and increased in 2 eyes. A significant correlation between volume and area was found(p < 0.001) as well as agreement between increase and decrease in volume and area. Conclusions: In the 3-dimensional quantitative volumetric analysis, the volume and area of HEs were correlatedand the direction of increase and decrease was concordant. Considering the distribution of HEs in multiplelayers of the retina, volumetric analysis could be considered a substitute for the analysis of HE area.
Abstract
Purpose: In the present study, the volume of hard exudates (HEs) was quantitatively measured using optical coherencetomography (OCT) and the agreement and correlation with area of HEs in fundus photography wereanalyzed. Methods: The medical records of patients with diabetic macular edema who underwent focal laser treatmentand were followed up more than 3 months were retrospectively evaluated. An automated customized programdesigned for measuring HE volume was used. The HEs in each OCT B-scan binary image were measuredusing 512 × 128 pixels, 6 mm × 6 mm OCT cube scans. The volume was measured by summing the segmentedHEs in each 128 B-scan image. The area was measured in 6 mm x 6 mm fundus photography. The volumeand area were measured before and 3 months after the treatment. The agreement of increase and decreasein HEs, and the correlation of volume and area of HEs were analyzed. Results: A total of 35 patients (39 eyes) were included in the study. The volume was significantly reduced from0.07978 to 0.02565 mm3 at 3 months (p < 0.001). The area was also significantly reduced from 15.35 to 8.60mm2 at 3 months (p < 0.001). The volume was decreased in 34 eyes and increased in 5 eyes. The area wasdecreased in 37 eyes and increased in 2 eyes. A significant correlation between volume and area was found(p < 0.001) as well as agreement between increase and decrease in volume and area. Conclusions: In the 3-dimensional quantitative volumetric analysis, the volume and area of HEs were correlatedand the direction of increase and decrease was concordant. Considering the distribution of HEs in multiplelayers of the retina, volumetric analysis could be considered a substitute for the analysis of HE area.
참고문헌 (21)
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