자간전증 임산부의 분만전 및 분만후 혈장 Matrix Metalloproteinase (MMP)-2, -9의 변화
The Plasma Level of Matrix Metalloproteinase (MMP)-2, -9 between Antepartum and Postpartum Period in Preeclampsia
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목적 : 자간전증 임산부의 혈장에서 MMP-2 및 MMP-9 값을 측정하여 정상 임신과 비교하고, 분만 전후 MMP-2 및 MMP-9 값의 변화를 알아보고자 하였다. 연구 방법 : 아주대병원 산부인과에서 분만한 자간전증 임산부 20명을 연구군으로, 연구군과 임산부의 나이, 분만시 재태연령, 산과력이 비슷한 정상 혈압의 임산부 20명을 대조군으로 분만전 및 분만 24시간 후에 임산부 혈장 MMP-2, -9 값을 enzyme-linked immunoassay 방법을 이용하여 측정하였다. 결과 : 혈장 MMP-2 값은 분만전 및 분만 24시간 후에 자간전증 임산부에서 대조군보다 의미있게 높았다 [516.33±98.75 vs 384.55±93.84 (ng/mL), p=0.002 분만전, 534.77±158.67 vs 336.04±139.11 (ng/mL), p=0.002 분만후 24시간]. 혈장 MMP-9 값은 분만전 자간전증군에서 의미있게 감소하였으며 [26.26±7.49 vs 45.00±20.31 (ng/mL), p=0.001], 분만후 24시간 후에도 대조군보다 감소한 소견을 보였으나 통계적 유의성은 없었다. 결론 : 혈장 MMP-2 값은 분만전 및 분만후 자간전증군에서 의미있게 높았으며 혈장 MMP-9 값은 분만전 자간전증군에서 의미있게 감소하였다.
Abstract
Objective : To evaluate the changes of plasma MMP-2, -9 levels in preeclampsia between antepartum and postpartum periods, and compare with normotensive pregnant. Methods : Plasma MMP-2, -9 levels were determined with enzyme-linked immunoassay in pregnant women with preeclampsia (n=20) compared to control group (normotensive pregnant women) matched by maternal age, gestational age, and parity (n=20). Results : Women with preeclampsia presented significantly higher plasma level of MMP-2 before delivery [516.33±98.75 vs 384.55±93.84 (ng/mL), p=0.002]. In postpartum 24 hours, women with preeclampsia exhibited higher plasma MMP-2 level compared control group [534.77±158.67 vs 336.04±139.11 (ng/mL), p=0.002]. But the plasma level of MMP-9 was significantly lower in preeclampsia group before delivery [26.26±7.49 vs 45.00±20.31 (ng/mL), p=0.001]. In postpartum 24 hours, women with preeclampsia also speculated lower plasma MMP-9 level compared control group, but no existence of significance. Conclusion : Plasma MMP-2 concentration is significantly increased in preeclampsia before delivey and postpartum 24 hours. Plasma MMP-9 concentration is significantly decreased in preeclampsia before delivery.
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