중증 자간전증이 동반된 임산부에서혈중 homocysteine치 측정의 의의
The Significance of Plasma Homocysteine Level in Pregnant Womenwith Severe Preeclampsia
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목적 : 증가된 혈중 homocysteine은 동맥경화증 발생의 중요한 독립적 위험인자이다. 동맥경화증과 비슷한 병태생리를 가지는 중증 자간전증 임산부의 혈장 homocysteine치를 측정하여 homocysteine값의 변화가 있는지를 알아보고자 하였다. 연구 방법 : 28명의 중증 자간전증 임산부 (연구군)와 연구군의 임산부 나이, 임신 주수, 산과력 및 임신전 체질량지수가 일치하는 정상 혈압을 가진 임산부 26명 (대조군)을 대상으로 분만전 24시간 이내, 분만후 24시간째에 혈중 homocysteine치를 비교하였다. 혈중 homocysteine은 fluorescent polarization immunoassay방법을 이용하였다. 통계처리는 Student t-test를 이용하였다. 결과 : 중증 자간전증이 있는 산모군에서 분만전 및 분만 24시간 후 평균 homocysteine은 대조군에 비해 분만 전 [7.17±2.71 vs 5.37±1.49 g/mL (mean SD); p<0.05]과 분만 후 [6.38±2.03 vs 4.48±0.40 g/mL (mean±SD); p<0.05] 모두 유의하게 높았다. 결론 : 혈중 증가된 homocysteine은 동맥경화증에서와 유사하게 자간전증의 발생과 관계가 있으며 향후 더 많은 연구대상을 통해 임신중독증의 예측 지표로서 사용될 수 있으리라 사료된다.
Abstract
Objective : The elevated plasma homocysteine concentrations is a independent risk factor of atherosclerosis. We investigated the level of plasma homocysteine is associated with severe preeclampsia. Methods : 28 pregnant women with severe preeclampsia (study group) and 26 normotensive, healthy pregnant women (control group), matched by maternal age, gestational age, pre-pregnant body mass index and parity were enrolled into this study. Blood samples were collected within 24 hours before delivery and just 24 hours after delivery. The level of plasma homocysteine was measured by fluorescent polarization immunoassay. Statistical analysis was performed using Student t test. Results : Plasma homocysteine levels in the women with severe preeclampsia were significantly elevated than those of control group in antepartum and postpartum 24 hours [7.17 2.71 vs 5.37 1.49 g/mL (mean SD); p<0.05 in antepartum, 6.38 2.03 vs 4.48±0.40 g/mL (mean SD); p<0.05 in postpartum]. Conclusion : In the present study the increase of plasma homocysteine in pregnant women with severe preeclampsia is related the pathogenesis of preeclampsia as like in atherosclerosis and may be used as a marker of preeclampsia by further research.
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