Phenylhydrazine으로 유발된 흰쥐의 용혈성 빈혈에 미치는 三七根의 효과
A Study about Inhibitory Effects of Panax notoginseng on Hemolytic Anemia
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Objectives : This study was performed in order to investigate the effect of Panax notoginseng(SCG) on phenylhydrazine (PHZ)-induced hemolytic anemia in rats. Materials and Methods : Rats were divided equally into 3 groups (Normal, Control, SCG). Anemic model rats (Control, SCG) were induced by the treatment of PHZ (40mg/kg/day, i.p.) for 3 days. Red blood cell, hemoglobin, reticulocyte count, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were determined on days 0, 4, 7 and 10. Body weight was investigated on days 0, 2, 4, 6, 8, 10 and weight of spleen was measured on day 10. Results : In the SCG group, significantly higher levels of RBC was found on day 4 and higher concentration of Hb on days 4, 7 and 10. Furthermore, reticulocyte count was dramatically lower on day 10 compared to the control group. Conclusions : These results suggest that SCG may be beneficial in the treatment of hemolytic anemia.
Abstract
Objectives : This study was performed in order to investigate the effect of Panax notoginseng(SCG) on phenylhydrazine (PHZ)-induced hemolytic anemia in rats. Materials and Methods : Rats were divided equally into 3 groups (Normal, Control, SCG). Anemic model rats (Control, SCG) were induced by the treatment of PHZ (40mg/kg/day, i.p.) for 3 days. Red blood cell, hemoglobin, reticulocyte count, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were determined on days 0, 4, 7 and 10. Body weight was investigated on days 0, 2, 4, 6, 8, 10 and weight of spleen was measured on day 10. Results : In the SCG group, significantly higher levels of RBC was found on day 4 and higher concentration of Hb on days 4, 7 and 10. Furthermore, reticulocyte count was dramatically lower on day 10 compared to the control group. Conclusions : These results suggest that SCG may be beneficial in the treatment of hemolytic anemia.
참고문헌 (22)
- Felder KM, "Antibodies to actin in autoimmune haemolytic anaemia", BMC Vet Res, 6, pp.18~26 (2010)
- 전국간계내과학 교수, "간계내과학", pp.541~551 (2001), 동양의학연구원출판부
- 中華人民共和國 衛生部藥典委員會, "中華人民共和國藥典", pp.11~ (2005), 化學工業出版社
- Park JA, "A study on the effect of Samchilgun in thrombosis and elevated blood viscosity", J. Oriental Medical Pathology, 7, pp.15~26 (1992)
- 권미향, "식물로부터 혈액 항응고 활성 다당류의 검색", 한국농화학회지, 39(2), pp.159~164 (1996)
- Park WH, "A Korean herbal medicine, Panax notoginseng, prevents liver fibrosis and hepatic microvascular dysfunction in rats", Life Sciences, 76(15), pp.1675~1690 (2005)
- Cardiovasscular Division, "Treatment of angina pectoris and animal experiments of Panax notoginseng, In National coronary Heart Diseases Conference", pp.262~ (1974), People's Health Publishing House
- Gao RL, "Experimental study of hematopoietic cell gene expression profile induced by panax notoginosides in vitro", Zhongguo Zhong Xi Yi Jie He Za Zhi, 27(11), pp.999~1003 (2007)
- Chen XH, "Expression of apoptosis-related proteins in the human bone marrow hematopoietic cells treated by Panax Notoginosides", Zhongguo Shi Yan Xue Ye Xue Za Zhi, 14(2), pp.343~346 (2006)
- Shelter MD, "Reactions of Hemoglobin with Phenylhydrazine: a review of Selected Aspects", Environ Health Perspect, 64, pp.265~281 (1985)
- Giffin HZ, "The control and complete remission of polycythemia vera following the prolonged administration of phenylhydrazine hydrochlorid", Am J Med, 185, pp.1~13 (1933)
- Barer A, "Studies on the relationship between oxygen consumption and nitrogen metabolism", III In Polycytehmia Vera. J Clin Invest, 13(1), pp.15~28 (1934)
- 김혼삼, "당귀보혈탕 및 구성약물이 용혈성 빈혈에 미치는 영향", 방제학회지, 4(6), pp.113~136 (1996)
- 임석린, "사물탕과 사물탕 구성약물이 혈구감소증에 미치는 영향에 관한 연구", 대전대학교 한의학연구원 논문집, 8(1), pp.837~851 (1999)
- 신혜숙, "雌性 흰쥐에서 phenylhydrazine으로 유발된 용혈성 빈혈에 오미자 약침의 항빈혈효과", Korean Journal of Acupuncture, 19(1), pp.8~77 (2002), 경락경혈학회
- Dhaliwal G, "Hemolytic Anemia", Am Fam Physician, 69(11), pp.1599~1606 (2004)
- 李時珍, "本草綱目", pp.767~768 (1982), 인민위생출판사
- Chakrabarti S, "Erythrocyte membrane protein damage by oxidation products of phenylhydrazine", Biochem Mol Biol Int, 35, pp.255~263 (1995)
- Valley AW, "Overview of cancer-related anemia: focus on the potential role of darbepoetin alfa", Pharmacotherapy, 22, pp.150~159 (2002)
- 박선양, "빈혈의 진단과 치료", 대한내과학회지, 53(2), pp.775~780 (1997)
- Xiea L, "Chien S. Studies on the biomechanical properties of maturing reticulocytes", J Biomech, 39, pp.530~535 (2006)
- 김상순, "正常 및 비적출 白鼠에 있어서 Phenylhydrazine에 의한 용혈성빈혈의 進行過程에 관한 硏究", 전북의대 논문집 제9권, 9(4), pp.359~363 (1985), 전북대학교 의과대학 병리학교실