본문 바로가기
KERD
논문KCI 등재

製何首烏加味方이 고지혈증 및 산화적 손상에 미치는 영향

The Effects of Jehasuogamibang on Antioxidation Activity and Dietary Hyperlipidemia-induced Mice

유호룡|김윤식|설인찬|조현경|윤현덕
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2014.09|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제35권 제3호|pp. 244-261

2

조회

0

다운로드

3

인용

0

참고문헌

키워드

HyperlipidemiaAntioxidation ActivityJehasuogamibang
주제분류한의학

초록

Objectives: This experiments were performed to determine the effects of the Jehasuogamibang (製何首烏加味方: JHGB)on antioxidationactivity and hyperlipidemia induced by a hypercholesterolemic diet in mice. Methods: After treatment with JHGB expert safety in cytotoxicity and toxicity of Human fibroblast cells and liver andkidney, effect on Reactive Oxygen Species, serum total cholesterol, LDL-cholesterol, triglyceride, glucose, HDL-cholesterol, lipidperoxid of liver tissue, significantly increased SOD and catalase. Results:1. JHGB showed safety in cytotoxicity and toxicity of human fibroblast cells and liver and kidney. 2. JHGB showed significant inhibitory effect on reactive oxygen species. 3. JHGB significantly decreased serum total cholesterol, LDL-cholesterol, triglyceride, and glucose, and significantly increasedserum HDL-cholesterol. 4. JHGB significantly decreased lipid peroxide of liver tissue and significantly increased SOD and catalase. Conclusions: These results suggest that Jehasuogamibang is effective in antioxidationactivity and dietary hyperlipidemia-inducedmice.

Abstract

Objectives: This experiments were performed to determine the effects of the Jehasuogamibang (製何首烏加味方: JHGB)on antioxidationactivity and hyperlipidemia induced by a hypercholesterolemic diet in mice. Methods: After treatment with JHGB expert safety in cytotoxicity and toxicity of Human fibroblast cells and liver andkidney, effect on Reactive Oxygen Species, serum total cholesterol, LDL-cholesterol, triglyceride, glucose, HDL-cholesterol, lipidperoxid of liver tissue, significantly increased SOD and catalase. Results:1. JHGB showed safety in cytotoxicity and toxicity of human fibroblast cells and liver and kidney. 2. JHGB showed significant inhibitory effect on reactive oxygen species. 3. JHGB significantly decreased serum total cholesterol, LDL-cholesterol, triglyceride, and glucose, and significantly increasedserum HDL-cholesterol. 4. JHGB significantly decreased lipid peroxide of liver tissue and significantly increased SOD and catalase. Conclusions: These results suggest that Jehasuogamibang is effective in antioxidationactivity and dietary hyperlipidemia-inducedmice.

참고문헌 (41)

  1. "사망원인통계" (2008), 통계청.[URL]
  2. 전국한의과대학 심계내과학교실, "한방순환신경내과학", pp.184~189 (2010), 군자출판사
  3. Mark H Beets, "머크 매뉴얼", pp.214~217 (2003), 한우리
  4. Jain KS, "The biology and chemistry of hyperlipidemia", Bioorg Med Chem, 15(14), pp.4674~4699 (2007)
  5. 신규성, "Power internal medicine", pp.300~317 (2000), 군자출판사
  6. 김광원, "고지혈증과 동맥경화", pp.3~8 (2003), 의학
  7. Walsh JM, "Drug treatment of hyperlipidemia in women", JAMA, 291(18), pp.2243~2252 (2004)
  8. Farnier M, "Current and future treatment of hyperlipidemia: the role of statins", Am J Cardiol, 82(4B), pp.3J~10J (1998)
  9. Law MR, "By how much and how quickly does reduction in serum cholesteril concentration lower risk of ischemic heart disease", BMJ, 308, pp.367~372 (1994)
  10. Jeon KJ, "Studies on the efficacy and safety of Atovastatin in hypercholesterolemic (LDL-cholesterol) patients", Korean Circulation K, 29, pp.1309~1316 (1999)
  11. Scandinavian Sinvastatin Survival Study Group, "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease. the Scandinavian Sinvastatin Survival Study(4S)", Lancet, 344, pp.1383~1389 (1994)
  12. 楊維傑, "黃帝內徑靈樞譯釋", pp.296~397 (1991), 일중사
  13. 방혜정, "고지혈증에 대한 한의학적 고찰", 동서의학, 20, pp.25~36 (1995)
  14. 黃春林, "心血管科專病中醫臨床診治", pp.124~ (2007), 人民衛生出版社
  15. 박정의, "관상동맥경화증 위험인자의 역학연구", 제14차 추계학술대회, pp.101~108 (1997)
  16. 김치정, "고지혈증", 대한내과학회지, 62, pp.44~57 (2002)
  17. Daniel J. Rader, "Harrison's Principles of Internal medicine. Section 3Disorders of Intermediary Metabolism", pp.2038~2040 (2006), MIP
  18. 이귀녕, "임상병리파일", pp.107~109 (2000), 의학문화사
  19. 서울대학교의과대학, "내분비학", pp.261~ (2005), 서울대학교출판사
  20. 신현호, "고지혈증의 약물요법", 한국지질학회 제1차 동맥경화와 고지혈증 Workshop, pp.41~49 (1994)
  21. Paaladinesh Thavendiranathan P, "Primary prevention of cardiovascular diseases with statin theraphy. A meta-analysis of randomized controlled trials", Arch Intern Med, 166, pp.2307~2313 (2006)
  22. Giugliano D, "Dietry antioxidants for cardiovascular prevention", Nutr Metab Cardiovasc Dis, 10(1), pp.38~44 (2000)
  23. 黃文東, "實用中醫內科學", pp.414~422 (1986), 人民衛生出版社
  24. 趙永康, "高脂血證治法審析", 中醫雜誌, 29(7), pp.66~ (1988)
  25. Halliwell B, "Free radicals, actioxidants, and human disease : Where are we now", J Lab Clin Med, 119, pp.598~620 (1992)
  26. Enterbauer H, "Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes", Free Radic Biol Med, 11, pp.81~128 (1991)
  27. Bedosa P, "Stimulation of collagen α1 gene expression is associated with lipid peroxidation in hapatocellular injury : A link to tissue fibrosis", Hepatology, 19, pp.1262~1271 (1994)
  28. Lee KS, "Activation of hepatic stellate cells by TGF-αand collagen type Ⅰ is mediated by oxidative stress through c-myb expression", J Clin Invest, 96, pp.2461~2468 (1995)
  29. Kamimura S, "Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease", Hepatology, 21, pp.1304~1309 (1995)
  30. Stocker R, "Endogenous antioxidant defences in human blood plasma (in Oxidative Stress and Antioxidants)", pp.213~242 (1991), Academic Press Ltd
  31. 이소연, "瓊玉膏의 성분 분석 및 추출물별 抗酸化 효능 비교", 대한본초학회지, 23(2), pp.123~136 (2008), 대한본초학회
  32. Deisseroth A, "Catalase physical and chemical properties, mechanism of catalysis, and physiological role", Physiological reviews, 50, pp.319~375 (1970)
  33. Araujo FB, "Evaluation of oxidative stress in patients with hyperlipidemia", Atherosclerosis, 117(1), pp.61~71 (1995)
  34. Yang RL, "Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index", J Clin Biochem Nutr, 43(3), pp.154~158 (2008)
  35. Arca M, "Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy", Free Radic Biol Med, 42(5), pp.698~705 (2007)
  36. Racek J, "The influence of folate and antioxidants on homocysteine levels and oxidative stress in patients with hyperlipidemia and hyperhomocysteinemia", Physiol Res, 54(1), pp.87~95 (2005)
  37. 이경민, "黃耆藥鍼液의 NO, DPPH 消去 및 IL-4 抑制效果", 대한침구의학회지, 20(2), pp.15~ (2003), 대한침구의학회
  38. 대한병리학회, "병리학", pp.112~122 (1994), 고문사
  39. 전미혜, "오적산이 자궁근종세포의 사멸과 Cell apoptosis에 미치는 영향", 석사, 한의학, pp.2003
  40. 강호영, "Kuby 면역학 (5판)", pp.31~ (2006), 월드사이언스
  41. Martin MJ, "Serum cholesterol, blood pressure, and mortality : implicaions from a cohort of 361662 men", Lancet, 2, pp.933~939 (1986)

관련 논문AI추천

하수오가미방이 고지혈증 SHR 및 항산화에 미치는 영향홍석, 김남욱, 김수익, 전상윤대한한방내과학회 · 대한한방내과학회지2009 · 제30권 제4호고지방 식이로 유발된 고지혈증 동물 모델에서 枸杞子加味方의 효과 연구신민구, 안가영, 전상윤, 조재준대한한방내과학회 · 대한한방내과학회지2014 · 제35권 제4호銳降脂湯이 고지혈증 SHR 및 항산화에 미치는 영향백경민대한한방내과학회 · 대한한방내과학회지2010 · 제31권 제4호益氣化瘀湯加味方이 고지방 식이로 유발된 생쥐의 항고지혈 및 항산화에 미치는 효과신용진, 전상윤한의병리학회 · 동의생리병리학회지2015 · 제29권 제5호循環器加減方이 고지혈증 유발 白鼠에 미치는 영향김동현, 김윤식, 설인찬, 안정조, 유호룡, 임승민, 조현경대한한방내과학회 · 대한한방내과학회지2010 · 제31권 제3호加味地黃湯이 高脂血症 關聯 因子에 미치는 영향김윤식, 박소애, 설인찬, 안정조, 유호룡, 조현경대한한방내과학회 · 대한한방내과학회지2009 · 제30권 제2호

이 간행물의 다른 논문 (13건)

GST 추출물의 Sprague-Dawley Rat를 이용한 13주 반복 경구투여 독성시험 및 4주 회복시험한종민, 김승형, 김준영, 진미림, 이혜영, 김윤하, 정인철, 박양춘pp. 223-243酒蒸黃連이 iNOS 활성 억제를 통해 생쥐 위⋅십이지장 점막에 미치는 영향임성우, 김명호pp. 262-273기침에 대한 비내시경을 이용한 寒熱辨證의 임상적 가치평가이희범, 정희재, 이범준, 정승기, 박의근, 백현정pp. 274-287황련해독탕 추출액의 각막염 원인균에 대한 항균효과김인수, 김광곤, 하동룡, 서진종, 신민구, 김의수, 전상윤pp. 288-297사람 신경모세포종 SH-SY5Y 세포주의 파킨슨 모델에 대한 小續命湯의 보호효과문아지, 우찬, 장철용, 신선호, 유주연, 김효린, 신용진pp. 298-308
원문 보기