Biometric Risk Factors for Corneal Neovascularization Associated with Hydrogel Soft Contact Lens Wear in Korean Myopic Patients
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: To investigate the biometric risk factors for corneal surface complications associated with hydrogelsoft contact lens (SCL) fitting in myopic patients in Korea. Methods: This is a retrospective case-control study. The records of 124 subjects (124 eyes) who wore SCLs ona daily basis were reviewed. Thirty-one patients (31 eyes) who were diagnosed with corneal neovascularization(NV) while wearing SCLs were included in the complication group. Ninety-three age- and sex-matchedpatients (93 eyes) who wore SCLs, who did not have corneal NV and who visited our clinic for correction of refractiveerrors were included in the control group. The degree of spherical equivalent, astigmatism and cornealbase curve radius (BCR) were compared in both groups. Results: Patients with NV exhibited poorer best corrected visual acuity and more myopia than controls (p = 0.008and 0.006, respectively). In univariate analysis, highly myopic patients (-9 diopters [D] or higher) were morelikely to experience NV (odds ratio [OR], 2.232; 95% confidence interval [CI], 1.602 to 3.105). High astigmatism(≥2 D) increased the risk of complications (OR, 2.717; 95% CI, 1.141 to 6.451). Steep cornea, in which BCR was<7.5 mm, also raised the risk of complications (OR, 4.000; 95% CI, 1.661 to 9.804). Flat cornea was not a riskfactor for the development of NV. Conclusions: High myopia, high astigmatism, and steep cornea seemed to be risk factors in the developmentof corneal NV in SCL wearers.
Abstract
Purpose: To investigate the biometric risk factors for corneal surface complications associated with hydrogelsoft contact lens (SCL) fitting in myopic patients in Korea. Methods: This is a retrospective case-control study. The records of 124 subjects (124 eyes) who wore SCLs ona daily basis were reviewed. Thirty-one patients (31 eyes) who were diagnosed with corneal neovascularization(NV) while wearing SCLs were included in the complication group. Ninety-three age- and sex-matchedpatients (93 eyes) who wore SCLs, who did not have corneal NV and who visited our clinic for correction of refractiveerrors were included in the control group. The degree of spherical equivalent, astigmatism and cornealbase curve radius (BCR) were compared in both groups. Results: Patients with NV exhibited poorer best corrected visual acuity and more myopia than controls (p = 0.008and 0.006, respectively). In univariate analysis, highly myopic patients (-9 diopters [D] or higher) were morelikely to experience NV (odds ratio [OR], 2.232; 95% confidence interval [CI], 1.602 to 3.105). High astigmatism(≥2 D) increased the risk of complications (OR, 2.717; 95% CI, 1.141 to 6.451). Steep cornea, in which BCR was<7.5 mm, also raised the risk of complications (OR, 4.000; 95% CI, 1.661 to 9.804). Flat cornea was not a riskfactor for the development of NV. Conclusions: High myopia, high astigmatism, and steep cornea seemed to be risk factors in the developmentof corneal NV in SCL wearers.
참고문헌 (18)
- Robertson DM, "The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and pseudomonas binding to corneal cells: an overview", Eye Contact Lens, 33, pp.394~398 (2007)
- Chalmers RL, "Risk factors for contact lens complications in US clinical practices", Optom Vis Sci, 87, pp.725~735 (2010)
- Jones LW, "Non-inflammatory corneal complications of contact lens wear", Cont Lens Anterior Eye, 24, pp.73~79 (2001)
- Markoulli M, "Corneal erosions in contact lens wear", Cont Lens Anterior Eye, 35, pp.2~8 (2012)
- Teo L, "A survey of contact lens complications in Singapore", Eye Contact Lens, 37, pp.16~19 (2011)
- Chalmers RL, "Age and other risk factors for corneal infiltrative and inflammatory events in young soft contact lens wearers from the Contact Lens Assessment in Youth (CLAY) study", Invest Ophthalmol Vis Sci, 52, pp.6690~6696 (2011)
- Dart JK, "Risk factors for microbial keratitis with contemporary contact lenses: a case-control study", Ophthalmology, 115, pp.1647~1654 (2008)
- Nichols JJ, "Tear film, contact lens, and patient factors associated with corneal staining", Invest Ophthalmol Vis Sci, 52, pp.1127~1137 (2011)
- Ozkan J, "Risk factors for corneal inflammatory and mechanical events with extended wear silicone hydrogel contact lenses", Optom Vis Sci, 87, pp.847~853 (2010)
- Ramamoorthy P, "Treatment, material, care, and patient-related factors in contact lens-related dry eye", Optom Vis Sci, 85, pp.764~772 (2008)
- Richdale K, "Frequency of and factors associated with contact lens dissatisfaction and discontinuation", Cornea, 26, pp.168~174 (2007)
- Stapleton F, "Risk factors for moderate and severe microbial keratitis in daily wear contact lens users", Ophthalmology, 119, pp.1516~1521 (2012)
- Martin R, "Corneal conjunctivalisation in long-standing contact lens wearers", Clin Exp Optom, 90, pp.26~30 (2007)
- Jeng BH, "Management of focal limbal stem cell deficiency associated with soft contact lens wear", Cornea, 30, pp.18~23 (2011)
- Morgan PB, "Central and peripheral oxygen transmissibility thresholds to avoid corneal swelling during open eye soft contact lens wear", J Biomed Mater Res B Appl Biomater, 92, pp.361~365 (2010)
- Papas E, "On the relationship between soft contact lens oxygen transmissibility and induced limbal hyperaemia", Exp Eye Res, 67, pp.125~131 (1998)
- Wagner H, "Risk factors for interruption to soft contact lens wear in children and young adults", Optom Vis Sci, 88, pp.973~980 (2011)
- Sutton-Tyrrell K, "Assessing bias in case-control studies. Proper selection of cases and controls", Stroke, 22, pp.938~942 (1991)