Effectiveness of Toric Orthokeratology in the Treatment of Patients with Combined Myopia and Astigmatism
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Purpose: The purpose of this multi-institute, single-group clinical trial was to evaluate the effectiveness andsafety of toric orthokeratology lenses for the treatment of patients with combined myopia and astigmatism. Methods: A total of 44 patients were included in this clinical trial. The patients ranged in age from 7 to 49 years,with myopia of -0.75 to -6.0 diopters (D) and astigmatism of 1.25 to 4.0 D. After excluding 21 subjects, 23 subjects(39 eyes) were analyzed after toric orthokeratology lens use. The subjects underwent ophthalmologicexamination after 1 day and 1, 2, 3, and 4 weeks of wearing overnight toric orthokeratology lenses. Results: A total of 19 subjects (31 eyes) completed the trial after five subjects (eight eyes) dropped out. In thepatients who completed the study by wearing lenses for 4 weeks, the myopic refractive error decreasedsignificantly by 2.60 ± 2.21 D (p < 0.001), from -3.65 ± 1.62 to -1.05 ± 1.64 D. The astigmatic refractive errorwere also significantly decreased by 0.63 ± 0.98 D (p = 0.001), from 2.07 ± 0.83 to 1.44 ± 0.99 D. The meanuncorrected and corrected visual acuities before wearing the lenses were 2.14 ± 0.80 logarithm of the logMAR(logMAR) and 0.05 ± 0.13 logMAR, respectively, which changed to 0.12 ± 0.30 logarithm of the logMAR (p <0.001) and 0.01 ± 0.04 logMAR (p = 0.156) after 4 weeks. No serious adverse reactions were reported duringthe clinical trial. Conclusions: Our results suggest that toric orthokeratology is an effective and safe treatment for correcting visualacuity in patients with combined myopia and astigmatism.
Abstract
Purpose: The purpose of this multi-institute, single-group clinical trial was to evaluate the effectiveness andsafety of toric orthokeratology lenses for the treatment of patients with combined myopia and astigmatism. Methods: A total of 44 patients were included in this clinical trial. The patients ranged in age from 7 to 49 years,with myopia of -0.75 to -6.0 diopters (D) and astigmatism of 1.25 to 4.0 D. After excluding 21 subjects, 23 subjects(39 eyes) were analyzed after toric orthokeratology lens use. The subjects underwent ophthalmologicexamination after 1 day and 1, 2, 3, and 4 weeks of wearing overnight toric orthokeratology lenses. Results: A total of 19 subjects (31 eyes) completed the trial after five subjects (eight eyes) dropped out. In thepatients who completed the study by wearing lenses for 4 weeks, the myopic refractive error decreasedsignificantly by 2.60 ± 2.21 D (p < 0.001), from -3.65 ± 1.62 to -1.05 ± 1.64 D. The astigmatic refractive errorwere also significantly decreased by 0.63 ± 0.98 D (p = 0.001), from 2.07 ± 0.83 to 1.44 ± 0.99 D. The meanuncorrected and corrected visual acuities before wearing the lenses were 2.14 ± 0.80 logarithm of the logMAR(logMAR) and 0.05 ± 0.13 logMAR, respectively, which changed to 0.12 ± 0.30 logarithm of the logMAR (p <0.001) and 0.01 ± 0.04 logMAR (p = 0.156) after 4 weeks. No serious adverse reactions were reported duringthe clinical trial. Conclusions: Our results suggest that toric orthokeratology is an effective and safe treatment for correcting visualacuity in patients with combined myopia and astigmatism.
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