대학 엘리트 투척선수의 IL-6 유전자와 PPAR-γ2 유전자의 다형성에 대한 특성 분석
Characterization of Polymorphisms in IL-6 and PPAR-γ2 Genes of Elite College Throwers
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In order to clarify the genetic influences on the athletic performance of throwing item, we performed the serial case-control studies using the -174G/C polymorphism(rs1800795) in interleukin-6 (IL-6) gene and Pro12Ala polymorphism(rs1801282) in peroxisome proliferator activator receptor gamma(PPAR-γ2) gene as the genetic markers. A total of 146 subjects were divided into controls(n=77) and throwers(n=69), respectively, and two genetic polymorphisms analyzed by Taqman method in automated genotyping system. In the case of the -174G/C polymorphism in IL-6 gene, the GG genotype and G allele were only detected in all subjects studied, and, thus, indicated the monomorphic patterns. However, in the case of the Pro12Ala polymorphism in PPAR-γ2 gene, there was the significant association in genotype distribution of this polymorphism between controls and throwers(p=.05). Especially, the Pro/Pro genotype was almost three times frequent in throwers than in controls(dominat model, odds ratio(95%CI)=3.00(0.92~9.79)). Therefore, the Pro12Ala polymorphism in PPAR-γ2 gene may be one of the useful genetic markers influencing the athletic performance of throwing item. Further studies using larger sample size and genetic polymorphisms in more candidate genes will be needed to clarify the polygenic nature on the athletic performance of throwing item.
Abstract
In order to clarify the genetic influences on the athletic performance of throwing item, we performed the serial case-control studies using the -174G/C polymorphism(rs1800795) in interleukin-6 (IL-6) gene and Pro12Ala polymorphism(rs1801282) in peroxisome proliferator activator receptor gamma(PPAR-γ2) gene as the genetic markers. A total of 146 subjects were divided into controls(n=77) and throwers(n=69), respectively, and two genetic polymorphisms analyzed by Taqman method in automated genotyping system. In the case of the -174G/C polymorphism in IL-6 gene, the GG genotype and G allele were only detected in all subjects studied, and, thus, indicated the monomorphic patterns. However, in the case of the Pro12Ala polymorphism in PPAR-γ2 gene, there was the significant association in genotype distribution of this polymorphism between controls and throwers(p=.05). Especially, the Pro/Pro genotype was almost three times frequent in throwers than in controls(dominat model, odds ratio(95%CI)=3.00(0.92~9.79)). Therefore, the Pro12Ala polymorphism in PPAR-γ2 gene may be one of the useful genetic markers influencing the athletic performance of throwing item. Further studies using larger sample size and genetic polymorphisms in more candidate genes will be needed to clarify the polygenic nature on the athletic performance of throwing item.
참고문헌 (38)
- 김기진, "운동능력과 유전적 요인", 코칭능력개발지, 6(2), pp.45~53 (2004), 한국코칭능력개발원
- 남상남, "소년체전 육상선수들의 체력검사에 의한 주전종목 선정의 기초 연구", 한국생활환경학회지, 7(1), pp.47~56 (2000)
- 남정훈, "고강도 훈련 기간에 커큐민 섭취가 지구성 및 저항성 종목선수들의 혈중 염증반응, 산화적 스트레스 및 운동수행력에 미치는 효과", 스포츠사이언스, 40(1), pp.295~305 (2022), 체육과학연구소[DOI]
- 종목별 특성에 따른 ACTN3 유전자 다형성과 파워지구력과의 관련성(제17권 제1호), "체육과학연구", 2006, 55~65, pp.국민체육진흥공단 한국스포츠정책과학원
- 변재경, "롤러 스피드 스케이팅 선수들의 ACTN-3 유전자 다형성에 따른 근기능 및 유·무산소성 능력", 운동과학, 21(3), pp.319~330 (2012), 한국운동생리학회[DOI]
- 성봉주, "엘리트 육상 투척 세부 종목별 나이, 체격요인과 기록의 특성 분석", 한국스포츠학회, 16(4), pp.1449~1461 (2018), 한국스포츠학회
- 안나영, "초등학생의 PPAR-γ2 유전자 다형성간의 신체구성, 체력, 혈중변인 및 12주 운동효과의 비교", 한국발육발달학회지, 18(2), pp.117~124 (2010), 한국발육발달학회
- 이재구, "육상투척 선수에서 AGT 유전자의 Met235Thr(rs699) 다형성 특성", 한국체육과학회지, 31(1), pp.771~780 (2022), 한국체육과학회
- 이재구, "PPAR-γ2 유전자의 Pro12Ala 다형성에 따른 복합운동 프로그램이 비만인 중년여성의 신체조성, 체력 및 혈중 생화학적 변인의 변화양상에 미치는 효과", 한국사회체육학회지, (49), pp.991~1004 (2012), 한국사회체육학회
- 강병용, "운동선수의 골밀도 및 신체조성에 미치는 사이토카인 유전자 변이의 효과에 관한 연구", 한국체육학회지, 46(3), pp.405~417 (2007), 한국체육학회
- Ahmetov, I. I., , Bulletin of Experimental Biology and Medicine, 146(5), pp.630~632 (2008)
- Baker, P. R. S., "Fatty acid transduction of nitric oxide signaling : multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands", Journal of Biological Chemistry, 280(51), pp.42464~42475 (2005)
- Barbalho, S. M., "Myokines : a descriptive review", Journal of Sports Medicine and Physical Fitness, 60(12), pp.1583~1590 (2020)
- Beamer, B. A., "Chromosomal localization and partial genomic structure of the human peroxisome proliferator activated receptor-gamma(hPPAR gamma)gene", Biochemical and Biophysical Research Communications, 233(3), pp.756~759 (1997)
- Ben-Zaken, S., "Genetic characteristics of competitive swimmers : a review", Biology of Sport, 39(1), pp.157~170 (2022)
- Ben-Zaken, S., "Increased prvalence of the IL-6-174C genetic polymorphism in long distance swimmers", Journal of Human Kinetics, 58, pp.121~130 (2017)
- Bowcock, A. M., "The human"interferon-beta 2", hepatocyte stimulating factor, Genomics, pp.1988, 3(1)[DOI]
- Bray. M. S., "The human gene map for performance and health-related fitness phenotypes : the 2006-2007 update", Medicine &Science in Sports & Exercise, 41(1), pp.35~73 (2009)
- de M ilander, L., "The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman Triathlon", Applied Physiology, Nutrition and Metabolism, 34(5), pp.858~865 (2009)
- Deeb, S. S., "A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity", Nature Genetics, 20(3), pp.284~287 (1998)
- Eider, J., "Association of the 174 G", C polymorphism of the IL6 gene in Polish power-oriented athletes, 2013, pp.53(1), 88~92
- Greene, M. E., "Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping", Gene Expression, 4(4-5), pp.281~299 (1995)
- Hinney, A., "Polygenic obesity in humans", Obesity Facts, 1(1), pp.35~42 (2008)
- Hughes, F. J., "Interleukin-6 inhibits bone formation in vitro", Bone and Mineral, 21(1), pp.21~28 (1993)
- Kishimoto, T., "The biology of IL-6", Blood, 74(1), pp.1~10 (1989)
- Kota, B. P., "A overview on biological mechanisms of PPARs", Pharmacological Research, 51(2), pp.85~94 (2005)
- Loos, R. J. F., "FTO : the first gene contributing to common forms of human obesity", Obesity review, 9(3), pp.246~250 (2008)
- Agnieszka Maciejewska-Karlowska, "Association between the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor Gamma Gene and Strength Athlete Status", PLoS ONE, 8(6), pp.e67172~ (2013), Public Library of Science (PLoS)[DOI]
- Maciejewska-Skrendo, A., "Genetic markers associated with power athlete status", Journal of Human Kinetics, 68, pp.17~36 (2019)
- Miyamoto-Mikami, E., "Heritability esrimates of endurance-related phenotypes : A systematic review and meta-analysis", Scandinavian Journal of Medicine and Science in Sports, 28(3), pp.834~845 (2017)
- Nanjan, M. J., "Thiazolidinediones as antidiabetic agents : A critical review", Bioorganic Chemistry, 77, pp.548~567 (2018)
- Pedersen, B. K., "Searching for the exercise factor: is IL-6 a candidate?", Journal of Muscle Research and Cell Motility, 24, pp.113~119 (2003)
- Razquin, C., "Evidence on three relevant obesogenes : MC4R, FTO and PPARγ. Approaches for personalized nutrition", Molecular Nutrition & Food Research, 55(1), pp.136~149 (2011)
- Juan Su, "Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population", BMJ Open Sport & Exercise Medicine, 6(1), pp.e000681~ (2020), BMJ[DOI]
- Terry, C. F., "Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation", The Journal of Biological Chemistry, 275(24), pp.18138~18144 (2000)
- Varilla-Delgado, D., "Genetics and sports performance : the presnet and future in the identification of talent for sports based on DNA testing", European Journal of Applied Physiology, 122(8), pp.1811~1830 (2022)
- Yang, N., "ACTN3 genotype is associated with human athletic performance", American Journal of Human Genetics, 73(3), pp.627~631 (2003)
- Yen, C-J., "Molecular scanning of the human peroxisome proliferator activated receptor γ(hPPAR γ)gene in diabetic Caucasians : Identification of a Pro12Ala PPARγ2missense mutation", Biochemical and Biophysical Research Communications, 241(1), pp.270~274 (1997)