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스펙트럼 영역 빛간섭단층촬영으로 측정한 사상판 두께의 연령에 따른 변화

Age-Related Changes in the Thickness of the Lamina Cribrosa Measured by Spectral Domain OCT

김재석|이주화|백동원
대한안과학회 (The Korean Ophthalmological Society)|2013.08|대한안과학회지 (Journal of The Korean Ophthalmological Society)|제54권 제8호|pp. 1261-1268

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키워드

AgeGlaucomaLamina cribrosa thicknessSpectral domain OCT
주제분류안과학

초록

목적: 사상판 두께의 연령에 따른 변화를 알아보고, 서로 다른 연령대 또는 성별 사이에서 의미있는 차이가 있는지를 살펴보고자 하였다. 대상과 방법: 건강한 지원자 100명 100안을 대상으로 하였고 사상판 두께와 서로 다른 연령대 또는 성별 사이의 관련성을 알아보기위해 특정 연령군(38세에서 49세와 78세에서 89세) 40명을 선정하였다. 안과적 기본검사와 함께 스펙트럼 영역 빛간섭단층촬영에서Enhanced Depth Imaging으로 사상판 두께를 측정하였다. 결과: 사상판 측정이 어려운 13명을 제외한 87명을 대상으로 하였고 평균 연령은 55.0 ± 19.5세였다. 평균 사상판 두께(LCT)는 231.3± 41.6 μm (범위는 152.5-327.5 μm)였다. 연령과 사상판 두께 사이에는 음의 상관관계를 보였고(LCT = -1.614 × age + 320.191 μm, 95% CI for slope -1.91 to -1.32, r2=0.572, p＜0.001) 성별에 따른 사상판 두께는 의미있는 차이가 없었다(p=0.623). 결론: 연령과 함께 감소하는 사상판 두께도 녹내장 진행의 위험요인으로 생각해 볼 수 있으며 녹내장 환자에서 사상판 두께를 측정하는것이 환자의 예후를 파악하는데 도움이 될 것으로 생각한다.

Abstract

Purpose: To measure the lamina cribrosa thickness (LCT) in vivo of healthy people and to determine any association between the LCT and age or sex. Methods: We evaluated 100 eyes of 100 healthy volunteers. Forty eyes were selected and divided into 2 specific age groups (38-49 and 78-89 years) and the differences were assessed with respect to age and sex. Each participant underwent a complete eye examination and the LCT was evaluated with spectral domain optical coherence tomography (OCT)using enhanced depth imaging (EDI) mode. Results: Eighty-seven eyes were considered for the measurement and analysis of the LCT and 13 eyes were excluded because of an unclear image for identifying the LCT. The mean age was 55.0 ± 19.5 years. The mean LCT in healthy volunteers was 231.3 ± 41.6 μm (range, 152.5 - 327.5 μm) and a negative relationship was found between LCT and age (LCT =-1.614 × age + 320.191 μm, 95% CI for slope -1.91 to -1.32, r2 = 0.572, p < 0.001). Regarding differences related to sex,males had relatively thicker LCT than females, irrespective of age, although not statistically significant (p = 0.623). Conclusions: The present study results showed a decrease in human LCT with increasing age. Therefore, a decreasing LCT with an increasing age could be considered a strong risk factor for the development of glaucoma. In addition, measuring the LCT may help to understand the disease prognosis.

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